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公开(公告)号：EP1540340A2
公开(公告)日：2005-06-15
申请号：EP03757829.1
申请日：2003-09-12
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： G01N33/487 , A61B3/10 , A61B10/00
CPC分类号： G01N33/487 , A61B2010/0067
摘要： The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up the contact lens and (b) feeding the analyte obtained according to step (a) into an analyzer. The process of the invention provides a new concept for noninvasively measuring various analytes occurring in the tear fluid that is comfortable to the user.
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公开(公告)号：EP1599508A1
公开(公告)日：2005-11-30
申请号：EP04715310.1
申请日：2004-02-27
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C08F8/00 , C08F299/00 , G02B1/04 , C08L29/04
摘要： The present invention relates to a copolymer, which is the reaction product of (a) a first prepolymer, comprising a bioactive moiety and at least one radically polymerizable group, and (b) a second prepolymer which is a polyvinyl alcohol having a weight average molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprises from 0.5 to 80 % structural units of formula (I) wherein: R is alkylene having up to 8 carbon atoms, R1 is hydrogen or alkyl having up to seven carbon atoms, and R2 is an olefinically unsaturated, electron-attracting copolymerizable radical.
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3.发明公开
公开(公告)号：EP1742729A1
公开(公告)日：2007-01-17
申请号：EP05715458.5
申请日：2005-02-22
申请人： EyeSense AG , NOVARTIS-PHARMA GMBH
CPC分类号： B01J13/046 , A61K9/5036 , B01J13/14
摘要： The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.
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4.发明授权
公开(公告)号：EP1742729B1
公开(公告)日：2009-09-09
申请号：EP05715458.5
申请日：2005-02-22
申请人： EyeSense AG , NOVARTIS-PHARMA GMBH
CPC分类号： B01J13/046 , A61K9/5036 , B01J13/14
摘要： The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.
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5.发明授权
公开(公告)号：EP1742729B8
公开(公告)日：2010-02-03
申请号：EP05715458.5
申请日：2005-02-22
申请人： EyeSense AG , Novartis Pharma GmbH
CPC分类号： B01J13/046 , A61K9/5036 , B01J13/14
摘要： The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.
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公开(公告)号：EP1540340B1
公开(公告)日：2011-08-03
申请号：EP03757829.1
申请日：2003-09-12
申请人： Novartis AG
IPC分类号： G01N33/487 , A61B3/10 , A61B10/00
CPC分类号： G01N33/487 , A61B2010/0067
摘要： The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up the contact lens and (b) feeding the analyte obtained according to step (a) into an analyzer. The process of the invention provides a new concept for noninvasively measuring various analytes occurring in the tear fluid that is comfortable to the user.
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公开(公告)号：EP2101838A1
公开(公告)日：2009-09-23
申请号：EP07857862.2
申请日：2007-12-19
申请人： NOVARTIS AG
摘要： The invention relates to a process for the manufacture of a hydrophilic coating on a biomedical article, which comprises treating the biomedical article for a time period of ≤ 5 minutes with a solution of an organic solvent comprising a polyanionic compound with a number average molecular weight Mn of > 5000, wherein the solution comprises less than 10% by weight of water, and wherein the solution is devoid of a cationic polymer. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.
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公开(公告)号：EP2122390A1
公开(公告)日：2009-11-25
申请号：EP08708741.7
申请日：2008-02-06
申请人： Novartis AG
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , C08J7/04 , Y10T428/31511
摘要： A method for making a contact lens comprising a core material and a coating thereon, the method comprising the steps of : (a) providing the core material; (b) applying one or more layers of a crosslinkable polycationic material, wherein the polycationic material is a reaction product of : (i) an epoxide of formula (I) wherein X equals bromo, chloro, iodo, or cyano, and R1, R2, R3, R4, independently of one another, are selected from the group consisting of hydrogen, linear or branched C1C6-alkyl, and linear or branched C1C6-alkyl which is substituted with halogen, and (ii) a polymer having repeating units comprising one or more secondary or tertiary amine group(s); (c) applying one or more layers of a polyanionic material; and (d) cross-linking the layers of polyelectrolytes formed by steps (b) and (c). The contact lenses obtainable by the method of the invention have desirable characteristics regarding adherence to the core material, durability, hydrophilicity, and wettability.
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公开(公告)号：EP2124819A2
公开(公告)日：2009-12-02
申请号：EP08717398.5
申请日：2008-03-05
申请人： Novartis AG
发明人： MÜLLER, Achim , KNUTH, Monika , SCHMID, Katharina , PASTERNACK, Ralf , ZOTZEL, Jens , OERTEL, Kai , REIFF, Christine , FUCHSBAUER, Hans-Lothar
CPC分类号： C08J7/047 , A61F2/14 , A61L27/28 , A61L27/34 , A61L27/50 , C08J2489/00 , G02C7/04 , C08L89/00
摘要： The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.
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