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公开(公告)号：EP2029572B1
公开(公告)日：2010-11-03
申请号：EP07798049.8
申请日：2007-06-04
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439
CPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , C07F7/0834
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：EP2029572A2
公开(公告)日：2009-03-04
申请号：EP07798049.8
申请日：2007-06-04
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439
CPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , C07F7/0834
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。 还包括使用这些衍生物来调节硬脂酰辅酶A去饱和酶活性的方法和包含此类衍生物的药物组合物。
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公开(公告)号：EP2245029B1
公开(公告)日：2015-04-15
申请号：EP09711989.5
申请日：2009-02-18
发明人： CHOWDHURY, Sultan , DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , JIA, Qi , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D417/04 , C07D417/14 , A61K31/427 , A61P3/00
CPC分类号： C07D417/04 , C07D417/14
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公开(公告)号：EP2414366A1
公开(公告)日：2012-02-08
申请号：EP10712932.2
申请日：2010-03-30
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , ZHANG, Zaihui
IPC分类号： C07D491/10 , A61K31/438 , A61P3/00
CPC分类号： C07D491/10
摘要： The present invention provides spiro derivatives that modulate the activity of stearoyl- CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl- CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：EP2245029A1
公开(公告)日：2010-11-03
申请号：EP09711989.5
申请日：2009-02-18
发明人： CHOWDHURY, Sultan , DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , JIA, Qi , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D417/04 , C07D417/14 , A61K31/427 , A61P3/00
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：EP2121671A1
公开(公告)日：2009-11-25
申请号：EP07857849.9
申请日：2007-12-19
发明人： DALES, Natalie , ZHANG, Zaihui , FONAREV, Julia , FU, Jianmin , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , SUN, Shaoyi
IPC分类号： C07D409/04 , C07D413/04 , C07D417/04 , A61K31/427 , A61K31/381
CPC分类号： C07D409/04 , C07D413/04 , C07D417/04
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：EP2066664A1
公开(公告)日：2009-06-10
申请号：EP07842746.5
申请日：2007-09-19
发明人： DALES, Natalie , ZHANG, Zaihui , KAMBOJ, Rajender , FU, Jianmin , SUN, Shaoyi , POKROVSKAIA, Natalia , SVIRIDOV, Serguei
IPC分类号： C07D417/04 , C07D417/14 , A61K31/427 , A61P3/10 , A61P3/04
CPC分类号： C07D417/04 , C07D417/14
摘要： The present application provides compounds of formula (I) that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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8.发明公开HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL 有权对于条件与升高的脂质水平的疾病合适的杂环化合物相关联的处理
公开(公告)号：EP2054408A2
公开(公告)日：2009-05-06
申请号：EP07873509.9
申请日：2007-08-13
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D409/04 , C07D417/04 , C07D417/14 , A61K31/427 , A61K31/381 , A61K31/433 , A61P3/06
CPC分类号： C07D409/04 , C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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9.发明授权Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level 有权对于条件与升高的脂质水平的疾病合适的杂环化合物相关联的处理
公开(公告)号：EP2054408B1
公开(公告)日：2016-07-13
申请号：EP07873509.9
申请日：2007-08-13
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D409/04 , C07D417/04 , C07D417/14 , A61K31/427 , A61K31/381 , A61K31/433 , A61P3/06
CPC分类号： C07D409/04 , C07D417/04 , C07D417/14
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公开(公告)号：EP2483264A1
公开(公告)日：2012-08-08
申请号：EP10761003.2
申请日：2010-10-01
发明人： DALES, Natalie , FU, Jianmin , JIA, Qi , POKROVSKAIA, Natalia , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D403/04 , C07D403/14 , C07D413/14 , C07D417/14 , A61K31/427 , A61P3/04
CPC分类号： C07D403/04 , C07D403/14 , C07D413/14 , C07D417/14
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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