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公开(公告)号：EP2245029B1
公开(公告)日：2015-04-15
申请号：EP09711989.5
申请日：2009-02-18
发明人： CHOWDHURY, Sultan , DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , JIA, Qi , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D417/04 , C07D417/14 , A61K31/427 , A61P3/00
CPC分类号： C07D417/04 , C07D417/14
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公开(公告)号：EP2245029A1
公开(公告)日：2010-11-03
申请号：EP09711989.5
申请日：2009-02-18
发明人： CHOWDHURY, Sultan , DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , JIA, Qi , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D417/04 , C07D417/14 , A61K31/427 , A61P3/00
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：EP3551626A1
公开(公告)日：2019-10-16
申请号：EP17728326.4
申请日：2017-05-19
发明人： ANDREZ, Jean-Christophe , BOGUCKI, David Earl , BURFORD, Kristen, Nicole , CHOWDHURY, Sultan , COHEN, Charles, Jay , DECKER, Shannon, Marie , DEHNHARDT, Christoph, Martin , DEVITA, Robert, Joseph , EMPFIELD, James, Roy , FOCKEN, Thilo , GRIMWOOD, Michael, Edward , HASAN, Syed, Abid , JIA, Qi , JOHNSON, James, Philip, Jr. , WILSON, Michael, Scott , ZENOVA, Alla, Yurevna
IPC分类号： C07D403/12 , C07D213/76 , C07D237/20 , C07D239/69 , C07D413/12 , C07D261/16 , C07D493/10 , C07D277/52 , C07D285/08 , A61K31/426 , A61P25/08
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公开(公告)号：EP3166939A1
公开(公告)日：2017-05-17
申请号：EP15744417.5
申请日：2015-07-07
发明人： ANDREZ, Jean-Christophe , BERGERON, Philippe , BICHLER, Paul Robert , CHOWDHURY, Sultan , DEHNHARDT, Christoph Martin , FOCKEN, Thilo , GONG, Wei , GRIMWOOD, Michael Edward , HASAN, Abid , HEMEON, Ivan William , JIA, Qi , SAFINA, Brian , SUN, Shaoyi , WILSON, Michael Scott , ZENOVA, Alla Yurevna
IPC分类号： C07D403/12 , C07D413/14 , C07D221/22 , C07D401/10 , C07D401/12 , C07D403/10 , C07D413/12 , C07C235/52 , C07D205/04 , C07D207/16 , C07D277/06 , C07D209/02 , C07D305/08 , A61K31/401 , A61P17/04
CPC分类号： C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
摘要： and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
摘要翻译： 本发明提供具有通式（I）的化合物; 及其药学上可接受的盐; 其中变量RA，RAA，下标n，下标q，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5，D和E具有本文所述的含义， 以及使用这些化合物和组合物的方法。
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公开(公告)号：EP2350091B1
公开(公告)日：2015-06-03
申请号：EP09741118.5
申请日：2009-10-13
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Lauren , FU, Jianmin , LANGILLE, Jonathan , LIU, Shifeng , SUN, Jianyu , SUN, Shaoyi , SVIRIDOV, Serguei , WOOD, Mark , ZENOVA, Alla
IPC分类号： C07D491/20 , C07D491/107 , A61K31/407 , A61P25/00 , A61P29/00
CPC分类号： C07D491/107 , C07D491/20
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6.发明公开ASYMMETRIC SYNTHESES FOR SPIRO-OXINDOLE COMPOUNDS USEFUL AS THERAPEUTIC AGENTS 审中-公开不对称合成FÜRSPIROOXINDOLVERBINDUNGEN ALS THERAPEUTISCHE WIRKSTOFFE
公开(公告)号：EP2838902A1
公开(公告)日：2015-02-25
申请号：EP13710961.7
申请日：2013-03-11
发明人： SUN, Shaoyi , FU, Jianmin , CHOWDHURY, Sultan , HEMEON, Ivan, William , GRIMWOOD, Michael, Edward , MANSOUR, Tarek, Suhayl
IPC分类号： C07D491/20 , A61K31/407 , A61P25/00
CPC分类号： C07D491/20 , C07D209/34 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D491/107
摘要： This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及某些螺 - 羟吲哚衍生物的不对称合成，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。
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公开(公告)号：EP1851205B1
公开(公告)日：2012-04-11
申请号：EP06748193.7
申请日：2006-02-08
发明人： CHAKKA, Nagasree , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-Min , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , RAINA, Vandna , SUN, Shaoyi , SVIRIDOV, Serguei , WINTHER, Michael, D. , ZHANG, Zaihui , ABREO, Melwyn , HOLLADAY, Mark, W. , LI, Wenbao , SUN, Sengen , TU, Chi , GSCHWEND, Heinz, W.
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： C07D237/20 , A61K31/00 , A61K31/501 , A61K31/551 , C07D237/22 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1846035B1
公开(公告)日：2011-09-21
申请号：EP06734555.3
申请日：2006-02-08
发明人： KAMBOJ, Rajender , WINTHER, Michael , FRASER, Robert , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-min , HOU, Duanjie , LIU, Shifeng , RAINA, Vandna , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SADALUPURE, Kashinath , SUN Shaoyi , KODUMURU, Vishnumurthy , CHAKKA, Nagasree , ZHANG, Zaihui , ABREO, Melwyn , KONDRATENKO, Mikhail, A. , HARVEY, Daniel, F. , HUDSON, Cindy, J. , LI, Wenbao , TU, Chi , SUN, Sengen , HOLLADAY, Mark , GSCHWEND, Heinz
CPC分类号： A61K31/64 , A61K31/00 , A61K31/4439 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
摘要翻译： 本发明涉及式（I）的SCD-1抑制剂的用途：其中x，y，V，W，G，J，L，M，R2，R3，R5，R5a，R6，R6a，R7， 本文定义R7a，R8和R8a与其他药物疗法组合以治疗不利的体重增加。
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公开(公告)号：EP1888595A2
公开(公告)日：2008-02-20
申请号：EP06750402.7
申请日：2006-04-11
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , BAGHERZADEH, Mehran Seid , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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公开(公告)号：EP3450428A1
公开(公告)日：2019-03-06
申请号：EP18197734.9
申请日：2014-11-26
发明人： ANDREZ, Jean-Christophe , BICHLER, Paul Robert , CHEN, Chien-An , CHOWDHURY, Sultan , DECKER, Shannon Marie , DEHNHARDT, Christoph Martin , FOCKEN, Thilo , GRIMWOOD, Michael Edward , HEMEON, Ivan William , JIA, Qi , LI, Jun , LIU, Zhiguo , ORTWINE, Daniel F. , SAFINA, Brian , SUTHERLIN, Daniel , SHENG, Tao , SUN, Shaoyi , WHITE, Andrew D. , WILSON, Michael Scott , ZENOVA, Alla Yurevna , ZHU, Jiuxiang
IPC分类号： C07D401/04 , C07D405/04 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D451/02 , C07D451/06 , C07D205/12 , C07D295/155 , C07D211/96 , C07D295/26
摘要： The invention provides compounds having the general formula I:
and pharmaceutically acceptable salts thereof, wherein the variables R A , R AA , subscript n, ring A, X 2 , L, subscript m, X 1 , R 1 , R 2 , R 3 , R 4 , R 5 , and R N have the meaning as described herein; compositions containing such compounds; and such compounds and compositions for use in methods of treatment.
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