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公开(公告)号：EP2029572B1
公开(公告)日：2010-11-03
申请号：EP07798049.8
申请日：2007-06-04
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439
CPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , C07F7/0834
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：EP2029572A2
公开(公告)日：2009-03-04
申请号：EP07798049.8
申请日：2007-06-04
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439
CPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , C07F7/0834
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。 还包括使用这些衍生物来调节硬脂酰辅酶A去饱和酶活性的方法和包含此类衍生物的药物组合物。
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3.发明授权Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level 有权对于条件与升高的脂质水平的疾病合适的杂环化合物相关联的处理
公开(公告)号：EP2054408B1
公开(公告)日：2016-07-13
申请号：EP07873509.9
申请日：2007-08-13
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D409/04 , C07D417/04 , C07D417/14 , A61K31/427 , A61K31/381 , A61K31/433 , A61P3/06
CPC分类号： C07D409/04 , C07D417/04 , C07D417/14
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4.发明公开HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL 有权对于条件与升高的脂质水平的疾病合适的杂环化合物相关联的处理
公开(公告)号：EP2054408A2
公开(公告)日：2009-05-06
申请号：EP07873509.9
申请日：2007-08-13
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D409/04 , C07D417/04 , C07D417/14 , A61K31/427 , A61K31/381 , A61K31/433 , A61P3/06
CPC分类号： C07D409/04 , C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：EP1846035A2
公开(公告)日：2007-10-24
申请号：EP06734555.3
申请日：2006-02-08
发明人： KAMBOJ, Rajender , WINTHER, Michael , FRASER, Robert , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-min , HOU, Duanjie , LIU, Shifeng , RAINA, Vandna , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SADALUPURE, Kashinath , SUN Shaoyi , KODUMURU, Vishnumurthy , CHAKKA, Nagasree , ZHANG, Zaihui , ABREO, Melwyn , KONDRATENKO, Mikhail, A. , HARVEY, Daniel, F. , HUDSON, Cindy, J. , LI, Wenbao , TU, Chi , SUN, Sengen , HOLLADAY, Mark , GSCHWEND, Heinz
CPC分类号： A61K31/64 , A61K31/00 , A61K31/4439 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
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6.发明公开HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS 有权杂环衍生物及其作为硬脂酰-coA去饱和酶抑制剂的用途
公开(公告)号：EP1804799A2
公开(公告)日：2007-07-11
申请号：EP05857721.4
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , RAINA, Vandna , SVIRIDOV, Serguei , KODUMURU, Vishnumurthy , CHAKKA, Nagasree , LIU, Shifeng , SUN, Shaoyi , HOU, Duanjie
IPC分类号： A61K31/501 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P1/06 , C07D403/00 , C07D237/00
CPC分类号： A61K31/501 , C07D237/24 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferebly a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, R3, R5 , R5a, R6, R6a, R7, R7a, R8 and R8a are difined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了治疗哺乳动物，优选人的SCD介导的疾病或病症的方法，其中所述方法包括向需要其的哺乳动物施用式（I）的化合物：其中x，y，G，J，K ，L，M，W，R 2，R 3，R 5，R 5a，R 6，R 6a，R 7，R 7a，R 8和R 8a是本文定义的。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：EP1851205B1
公开(公告)日：2012-04-11
申请号：EP06748193.7
申请日：2006-02-08
发明人： CHAKKA, Nagasree , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-Min , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , RAINA, Vandna , SUN, Shaoyi , SVIRIDOV, Serguei , WINTHER, Michael, D. , ZHANG, Zaihui , ABREO, Melwyn , HOLLADAY, Mark, W. , LI, Wenbao , SUN, Sengen , TU, Chi , GSCHWEND, Heinz, W.
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： C07D237/20 , A61K31/00 , A61K31/501 , A61K31/551 , C07D237/22 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1846035B1
公开(公告)日：2011-09-21
申请号：EP06734555.3
申请日：2006-02-08
发明人： KAMBOJ, Rajender , WINTHER, Michael , FRASER, Robert , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-min , HOU, Duanjie , LIU, Shifeng , RAINA, Vandna , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SADALUPURE, Kashinath , SUN Shaoyi , KODUMURU, Vishnumurthy , CHAKKA, Nagasree , ZHANG, Zaihui , ABREO, Melwyn , KONDRATENKO, Mikhail, A. , HARVEY, Daniel, F. , HUDSON, Cindy, J. , LI, Wenbao , TU, Chi , SUN, Sengen , HOLLADAY, Mark , GSCHWEND, Heinz
CPC分类号： A61K31/64 , A61K31/00 , A61K31/4439 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
摘要翻译： 本发明涉及式（I）的SCD-1抑制剂的用途：其中x，y，V，W，G，J，L，M，R2，R3，R5，R5a，R6，R6a，R7， 本文定义R7a，R8和R8a与其他药物疗法组合以治疗不利的体重增加。
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9.发明公开AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS 审中-公开AMINOTHIAZOLDERIVATE ALS人硬脂酰辅酶A DESATURASEHEMMER
公开(公告)号：EP2029138A1
公开(公告)日：2009-03-04
申请号：EP06784578.4
申请日：2006-06-05
发明人： FU, Jianmin , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , SVIRIDOV, Serguei , ZHANG, Zaihui
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4439 , A61P3/00 , A61P9/12 , A61P17/06 , A61P17/10 , A61P19/06 , C07D277/82 , C07D417/12
CPC分类号： C07D277/587 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/616 , A61K38/26 , A61K38/28 , A61K45/06 , C07D277/56 , C07D417/06 , C07D417/12
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where V, W, R1, R2, R3 and R4 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1888595A2
公开(公告)日：2008-02-20
申请号：EP06750402.7
申请日：2006-04-11
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , BAGHERZADEH, Mehran Seid , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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