公开(公告)号：EP0877630A2

公开(公告)日：1998-11-18

申请号：EP97900316.0

申请日：1997-01-09

申请人： NYCOMED IMAGING AS

发明人： COCKBAIN, Julian ,  GUNTHER, Wolfgang ,  KELLAR, Kenneth ,  FUJII, Dennis, Kiyoshi ,  DESAI, Vinay ,  BLACK, Christopher ,  BEEBER, Marshall ,  WELLONS, Jennifer ,  FAHLVIK, Anne, Kjersti ,  NAEVESTAD, Anne ,  NA, George ,  YUAN, Barbara ,  STEVENS, Jack ,  WEEKLEY, Brian ,  ENGELL, Torgrim ,  GACEK, Michel ,  LADD, David, Lee ,  SINGH, Jasbir ,  BACON, Edward, Richard ,  McINTIRE, Gregory, Lynn ,  SNOW, Robert, Alan

IPC分类号： A61K49 ,  C01G49 ,  C08J3 ,  C08L3

CPC分类号： B82Y5/00 ,  A61K49/049 ,  A61K49/1842 ,  A61K49/186 ,  A61K49/1863

摘要： The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.

公开(公告)号：EP0808175A1

公开(公告)日：1997-11-26

申请号：EP96901441.0

申请日：1996-02-02

申请人： NYCOMED IMAGING AS ,  COCKBAIN, Julian Roderick Michaelson

发明人： KLAVENESS, Jo ,  FUGLAAS, Bjorn ,  RONGVED, Pal ,  JOHANNESEN, Edvin ,  HENRICHS, Paul, Mark ,  GUNTHER, Wolfgang, Hans, Heinrich ,  BACON, Edward, Richard ,  TONER, John, Luke ,  McINTIRE, Gregory, Lynn

IPC分类号： A61K49

CPC分类号： A61K49/0034 ,  A61K49/0015 ,  A61K49/0021 ,  A61K49/0043 ,  A61K49/0084 ,  A61K49/0093 ,  A61K49/0433 ,  A61K49/223 ,  A61K49/227

摘要： The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

公开(公告)号：EP0808175B1

公开(公告)日：2002-07-31

申请号：EP96901441.4

申请日：1996-02-02

申请人： Nycomed Imaging AS

发明人： KLAVENESS, Jo ,  FUGLAAS, Bjorn ,  RONGVED, Pal ,  JOHANNESEN, Edvin ,  HENRICHS, Paul, Mark ,  GUNTHER, Wolfgang, Hans, Heinrich ,  BACON, Edward, Richard ,  TONER, John, Luke ,  McINTIRE, Gregory, Lynn

IPC分类号： A61K49/00

CPC分类号： A61K49/0034 ,  A61K49/0015 ,  A61K49/0021 ,  A61K49/0043 ,  A61K49/0084 ,  A61K49/0093 ,  A61K49/0433 ,  A61K49/223 ,  A61K49/227

公开(公告)号：EP0975372A1

公开(公告)日：2000-02-02

申请号：EP98922945.5

申请日：1998-05-22

申请人： NYCOMED IMAGING AS ,  COCKBAIN, Julian

发明人： COCKBAIN, Julian ,  MCINTIRE, Gregory, Lynn ,  TONER, John, Luke ,  BACON, Edward, Richard ,  HAYLEY, Patrick, Joseph

IPC分类号： A61K49/04

CPC分类号： B82Y5/00 ,  A61K49/0485 ,  A61K49/1815

摘要： The invention relates to the use of particulate contrast media in the in vivo imaging of lung draining lymph nodes, e.g. to stage lung cancer patients.

公开(公告)号：EP0941126A1

公开(公告)日：1999-09-15

申请号：EP97913321.0

申请日：1997-11-21

申请人： NYCOMED IMAGING AS ,  COCKBAIN, Julian Roderick Michaelson

发明人： McINTIRE, Gregory, Lynn ,  LADD, David, Lee ,  BACON, Edward, Richard ,  TONER, John, Luke ,  NA, George, Chao

IPC分类号： A61K49

CPC分类号： A61K49/0054 ,  A61K49/0433 ,  A61K49/128

摘要： The invention provides a method for contrast enhanced imaging of at least part of the lymphatic system of a human or animal body which comprises administering a diagnostically effective contrast agent to said body and generating a contrast enhanced image of at least part of the lymphatic system of said body, characterised in that said agent is a water-soluble polymeric material having a molecular weight of at least 1kD and is administered indirectly but parenterally.