公开(公告)号：EP3215603A4

公开(公告)日：2018-05-30

申请号：EP15857287

申请日：2015-11-05

Applicant: ORGANOVO INC ,  OREAL

Inventor： RETTING KELSEY NICOLE ,  O'NEILL COLIN M ,  NGUYEN DEBORAH LYNN GREENE ,  PRESNELL SHARON C ,  DEMAUDE JULIEN ,  WU ELIZABETH ,  BALOOCH GUIVE ,  LANGER JESSICA

IPC: C12N5/07 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/078 ,  C12N5/09 ,  C12Q1/02 ,  G01N33/50

CPC classification number: C12N5/0698 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2503/06 ,  C12N2533/54 ,  C12N2533/74 ,  C12N2533/90 ,  C12N2535/00

Abstract: Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.

公开(公告)号：EP3204488A4

公开(公告)日：2018-03-21

申请号：EP15848294

申请日：2015-10-06

Applicant: ORGANOVO INC

Inventor： NGUYEN DEBORAH LYNN GREENE ,  KING SHELBY MARIE ,  PRESNELL SHARON C

IPC: C12N5/071 ,  G01N33/50

CPC classification number: G01N33/5014 ,  C12N5/0684 ,  C12N5/0697 ,  C12N2502/1323 ,  C12N2502/256 ,  C12N2502/28 ,  G01N33/5044 ,  G01N2500/02 ,  G01N2500/10

Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.

公开(公告)号：EP3126490A4

公开(公告)日：2017-09-13

申请号：EP14887943

申请日：2014-06-06

Applicant: ORGANOVO INC ,  UNIV OREGON HEALTH & SCIENCE

Inventor： KING SHELBY MARIE ,  NGUYEN DEBORAH LYNN GREENE ,  GORGEN VIVIAN A ,  SHEPHERD BENJAMIN R ,  PRESNELL SHARON C ,  SEARS ROSALIE ,  ALLEN-PETERSEN BRITTANY ,  LANGER ELLEN

IPC: C12N5/09

CPC classification number: G01N33/5011 ,  B33Y10/00 ,  B33Y80/00 ,  C12N5/0656 ,  C12N5/0693 ,  C12N5/0697 ,  C12N2502/13 ,  C12N2502/1305 ,  C12N2502/1323 ,  C12N2502/1358 ,  C12N2502/28 ,  C12N2513/00 ,  C12N2533/74 ,  G01N33/5082

Abstract: Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.

Abstract translation: 描述了三维，工程化，生物乳房组织，脂肪组织和肿瘤模型，包括乳腺癌模型。