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1.发明公开METHOD FOR EXTRACELLULAR MATRIX MEDIATED DIFFERENTIATION AND PROLIFERATION OF STEM CELLS 有权方法细胞外基质SWITCHED分化干细胞的增殖
公开(公告)号：EP2229435A4
公开(公告)日：2011-10-12
申请号：EP08856713
申请日：2008-12-05
Applicant: AGENCY SCIENCE TECH & RES
Inventor： YING JACKIE Y , WAN ANDREW CHWEE AUN , NARAYANAN KARTHIKEYAN , SCHUMACHER KARL M
IPC: C12N5/02 , C12N5/0735 , C12N5/0775
CPC classification number: C12N5/0606 , C12N5/0663 , C12N2502/13 , C12N2502/22 , C12N2502/256 , C12N2533/90
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2.发明公开METHOD FOR INDUCTION OF DIFFERENTIATION OF ES CELL 有权VERFAHREN ZUR INDUKTION VON STAMMZELLDIFFERENZIERUNG
公开(公告)号：EP2169051A1
公开(公告)日：2010-03-31
申请号：EP08777040.0
申请日：2008-05-30
Applicant: Kumamoto University
Inventor： KUME, Shoen , SHIRAKI, Nobuaki , UMEDA, Kahoko , KUME, Kazuhiko
IPC: C12N5/00 , C12N5/06 , C12Q1/02 , G01N21/78 , G01N33/15 , G01N33/48 , G01N33/49 , G01N33/50 , C12N15/09
CPC classification number: C12N5/067 , C12N2501/115 , C12N2501/12 , C12N2501/16 , C12N2501/237 , C12N2501/39 , C12N2502/256 , C12N2506/02 , G01N33/5073
Abstract: It is an object of the present invention to establish a system for reliably differentiating an ES cell into a hepatic cell. The present invention provides a method for inducing the differentiation of an ES cell into a hepatic cell, which comprises, in the presence of an M15 cell, culturing a mammal-derived ES cell in the presence of activin and bFGF, and then culturing the ES cell in the presence of dexamethasone, HGF, and oncostatin M.
Abstract translation: 本发明的目的是建立一种可靠地将ES细胞分化为肝细胞的系统。 本发明提供了诱导ES细胞分化为肝细胞的方法，其包括在M15细胞存在下，在激活素和bFGF存在下培养来自哺乳动物的ES细胞，然后培养ES 在地塞米松，HGF和制瘤素M存在下的细胞。
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3.发明公开METHODE DE PRODUCTION ET DE CRYOCONSERVATION D'EMBRYONS BOVINS DEVELOPPES IN VITRO ET PAILLETTE CONGELEE POUR LE TRANSFERT DIRECT DE CEUX-CI 审中-公开方法用于生产和开发的体外胚胎牛和低CHILLED秸秆对直接传输相同冷冻保存
公开(公告)号：EP1287117A1
公开(公告)日：2003-03-05
申请号：EP01940650.3
申请日：2001-05-31
Inventor： JOLY, Catherine, Louise , MARQUANT-LEGUIENNE, Brigitte, Michèle , HUMBLOT, Patrice, Christian
CPC classification number: C12N15/873 , A01N1/02 , A01N1/0221 , C12N5/0604 , C12N2502/256
Abstract: The invention concerns a method for producing cryopreserved bovine embryos from bred oocytes in vitro comprising the following steps: 1) maturing and breeding bovine oocytes in vitro; 2) culturing in vitro said bred oocytes until the morula or blastocyst stage; 3) selecting quality 1 embryos; 4) freezing the selected embryos. The culturing step (2) is a co-culture on a mat of Vero cells carried out serum-free, and the freezing step (4) is carried out while the embryo is conditioned in a freezing medium containing a glycerol-trehalose mixture as cryoprotectant.
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4.发明公开METHOD FOR EXTRACELLULAR MATRIX MEDIATED DIFFERENTIATION AND PROLIFERATION OF STEM CELLS 有权方法细胞外基质SWITCHED分化干细胞的增殖
公开(公告)号：EP2229435A1
公开(公告)日：2010-09-22
申请号：EP08856713.6
申请日：2008-12-05
Applicant: Agency for Science, Technology And Research
CPC classification number: C12N5/0606 , C12N5/0663 , C12N2502/13 , C12N2502/22 , C12N2502/256 , C12N2533/90
Abstract: There is provided a method of culturing a stem cell on extracellular matrix extracted from support cells and in a stem cell culture medium comprising medium conditioned by the support cells
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5.发明公开METHOD OF FORMING NORMAL REGENERATED TISSUE, THE NORMAL REGENERATED TISSUE, AND METHOD OF CALIBRATING SENSTIVITY AND SO ON 有权方法地层师范大学再生体; 校准灵敏度和LIKE的正常再生组织和方法
公开(公告)号：EP1444994A4
公开(公告)日：2009-07-15
申请号：EP02777835
申请日：2002-10-15
Applicant: JAPAN SCIENCE & TECH AGENCY
Inventor： NAKATSUGAWA SHIGEKAZU
IPC: A61L27/36 , A61L27/38 , A61P43/00 , C12N5/02 , C12N5/071 , A61K35/12 , A61K35/23 , A61K35/24 , A61K35/30 , A61K35/36 , A61K35/407
CPC classification number: C12N5/0625 , A61K35/12 , A61L27/3604 , A61L27/3813 , C12N5/0697 , C12N2502/088 , C12N2502/095 , C12N2502/246 , C12N2502/256 , C12N2502/28 , C12N2502/30 , C12N2503/00 , C12N2503/04
Abstract: A normal regenerated tissue is formed by exposing to radiation a connective tissue or a supporting tissue originating in an organ to thereby form a feeder layer and then transplanting epithelial cells thereon to form a stratified structure. By conveniently and surely providing regenerated tissue by the 3-dimensional culture with the use of a human-origin normal tissue as a base, it is possible to construct systems for assessing effects and side effects of chemicals such as drugs or assessing sensitivities thereof with the use of regenerated tissues as models of corresponding tissues respectively.
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Patent Agency Ranking
公开(公告)号：EP1795590A1
公开(公告)日：2007-06-13
申请号：EP07003479.8
申请日：1999-04-26
Inventor： Scholl, David R. , Huang, Yung T. , Goodrum, Patricia Gail Ray
CPC classification number: G01N33/5091 , C12N5/0697 , C12N2502/256 , C12N2502/27 , C12N2502/30 , C12N2503/04 , C12Q1/04
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to the compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides kits comprising the compositions for detecting and differentiating one or more viruses or other intracellular parasites.
Abstract translation: 本发明一般涉及诊断微生物领域，更具体地说涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。 本发明还提供了包含用于检测和分化一种或多种病毒或其它细胞内寄生虫的组合物的试剂盒。
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7.发明公开METHOD OF FORMING NORMAL REGENERATED TISSUE, THE NORMAL REGENERATED TISSUE, AND METHOD OF CALIBRATING SENSTIVITY AND SO ON 有权方法地层师范大学再生体; 校准灵敏度和LIKE的正常再生组织和方法
公开(公告)号：EP1444994A1
公开(公告)日：2004-08-11
申请号：EP02777835.6
申请日：2002-10-15
Applicant: Japan Science and Technology Agency
Inventor： Nakatsugawa, Shigekazu
CPC classification number: C12N5/0625 , A61K35/12 , A61L27/3604 , A61L27/3813 , C12N5/0697 , C12N2502/088 , C12N2502/095 , C12N2502/246 , C12N2502/256 , C12N2502/28 , C12N2502/30 , C12N2503/00 , C12N2503/04
Abstract: A normal regenerated tissue is formed by exposing to radiation a connective tissue or a supporting tissue originating in an organ to thereby form a feeder layer and then transplanting epithelial cells thereon to form a stratified structure. By conveniently and surely providing regenerated tissue by the 3-dimensional culture with the use of a human-origin normal tissue as a base, it is possible to construct systems for assessing effects and side effects of chemicals such as drugs or assessing sensitivities thereof with the use of regenerated tissues as models of corresponding tissues respectively.
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公开(公告)号：EP3204488A4
公开(公告)日：2018-03-21
申请号：EP15848294
申请日：2015-10-06
Applicant: ORGANOVO INC
Inventor： NGUYEN DEBORAH LYNN GREENE , KING SHELBY MARIE , PRESNELL SHARON C
CPC classification number: G01N33/5014 , C12N5/0684 , C12N5/0697 , C12N2502/1323 , C12N2502/256 , C12N2502/28 , G01N33/5044 , G01N2500/02 , G01N2500/10
Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
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公开(公告)号：EP1071827B1
公开(公告)日：2007-02-21
申请号：EP99920029.8
申请日：1999-04-26
Inventor： SCHOLL, David, R. , HUANG, Yung, T. , GOODRUM, Patricia, Gail, Ray
CPC classification number: G01N33/5091 , C12N5/0697 , C12N2502/256 , C12N2502/27 , C12N2502/30 , C12N2503/04 , C12Q1/04
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of an organism to antimicrobial agents.
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10.发明授权BIOARTIFICIAL KIDNEY DEVICES COATED WITH CELLS SUITABLE FOR USE IN VIVO OR EX VIVO 失效与细胞包膜人工肾相关的设备在体内或体外使用
公开(公告)号：EP0746343B1
公开(公告)日：2004-01-02
申请号：EP94930647.6
申请日：1994-10-11
Applicant: The Regents of The University of Michigan
Inventor： HUMES, David, H. , CIESLINSKI, Deborah, A.
CPC classification number: C12N5/0687 , A61F2/022 , A61K35/12 , A61K48/00 , C12M21/08 , C12M23/06 , C12M25/02 , C12M29/04 , C12M29/16 , C12N5/069 , C12N5/0697 , C12N2501/11 , C12N2501/15 , C12N2501/385 , C12N2502/256 , C12N2502/28 , C12N2510/00 , C12N2533/54
Abstract: A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Renal cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure as well as studying renal tubululogenesis in vitro.
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