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公开(公告)号：EP1555267A1
公开(公告)日：2005-07-20
申请号：EP03754085.3
申请日：2003-10-10
发明人： TSUBOUCHI, Hidetsugu , SASAKI, Hirofumi , KURODA, Hideaki , ITOTANI, Motohiro , HASEGAWA, Takeshi; Daiichiaijitsuhaitsu 607, , HARAGUCHI, Yoshikazu , KURODA, Takeshi , MATSUZAKI, Takayuki , TAI, Kuninori , KOMATSU, Makoto , MATSUMOTO, Makoto , HASHIZUME, Hiroyuki; Daiaparesu 1401, , TOMISHIGE, Tatsuo , SEIKE, Yuji , KAWASAKI, Masanori , SUMIDA, Takumi , MIYAMURA, Shin; 147-13, Mukaininokoshi,
IPC分类号： C07D498/04 , C07D498/20 , C07D519/00 , A61K31/424
CPC分类号： C07D498/04 , C07D498/20 , C07F7/0812
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula:
wherein R 1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R 2 represents a group -OR 3 or the like, and R 3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R 1 and -(CH 2 ) n R 2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H):
wherein R 41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and a typical acid-fast bacteria.摘要翻译： 本发明提供由以下通式表示的2,3-二氢-6-硝基咪唑并[1,2-a]恶唑化合物：其中R 1表示氢原子或C 1 -C 6烷基，n表示整数 0至6，R 2代表基团-OR 3等，R 3表示氢原子，C 1 -C 6烷基等，或R 1和 - （CH 2）n R 2可以通过氮原子与与其相邻的碳原子彼此结合，形成由通式（H）表示的螺环：其中R 41是氢，C1-C6烷基或 类似。 本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和典型的耐酸细菌具有优异的杀菌作用。
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2.发明公开
公开(公告)号：EP2467364A2
公开(公告)日：2012-06-27
申请号：EP10751720.3
申请日：2010-08-20
发明人： OSHIMA, Kunio , MATSUMURA, Shuuji , YAMABE, Hokuto , ISONO, Naohiro , TAKEMURA, Noriaki , TAIRA, Shinichi , OSHIYAMA, Takashi , MENJO, Yasuhiro , NAGASE, Tsuyoshi , UEDA, Masataka , KOGA, Yasuo , NAKAYAMA, Sunao , TSUJIMAE, Kenji , ONOGAWA, Toshiyuki , TAI, Kuninori , ITOTANI, Motohiro
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048 , C07D495/04 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/12 , C07D519/00 , C07D471/04 , C07D215/227
CPC分类号： C07D491/048 , C07D213/38 , C07D215/227 , C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： The present invention provides a novel diazepine compound that blocks the I
Kur current or the Kv1.5 channel potently and more selectively than other K
+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R
1 , R
2 , R
3 , and R
4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R
2 and R
3 may be linked to form lower alkylene; A
1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y
1 and Y
2 are each independently -N= or -CH=; and R
5 is group represented by (2) wherein R
6 and R
7 are each independently hydrogen or organic group; R
6 and R
7 may be linked to form a ring together with the neighboring group -X
A -N-X
B -; X
A and X
B are each independently a bond, lower alkylene, etc.-
公开(公告)号：EP3022199A1
公开(公告)日：2016-05-25
申请号：EP14748306.9
申请日：2014-07-16
发明人： SATO, Seiji , MATSUDA, Satoshi , MATSUMURA, Chiharu , ITOTANI, Motohiro , SHINOHARA, Toshio , FUJITA, Shigekazu , SAKURAI, Yohji , TAI, Kuninori , FUKUSHIMA, Tae , KANEMOTO, Naohide , OKAMOTO, Takashi
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D411/12 , C07D411/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D249/04 , C07D249/06 , A61K31/4192
CPC分类号： C07D249/06 , C07D249/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D409/12 , C07D409/14 , C07D411/12 , C07D411/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07F9/5456
摘要： This invention relates to a cyanotriazole compound represented by the formula (1): wherein each symbols are defined in the specification, or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.
摘要翻译： 本发明涉及由式（1）表示的氰基三唑化合物或其盐，其中每个符号在说明书中定义。 该化合物或其盐可以刺激柠檬酸循环活性和/或改善高血糖症，副作用少，安全性优异，因此可用于治疗和/或预防柠檬酸循环活性化和/或预防 高血糖的改善具有预防和/或治疗效果，例如糖尿病，葡萄糖耐量降低，胰岛素抵抗，糖尿病并发症，肥胖症，血脂异常，肝脂肪变性，动脉粥样硬化和/或心血管疾病以及有益于的疾病或病症 从刺激能源开支。
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公开(公告)号：EP1555267B1
公开(公告)日：2013-01-16
申请号：EP03754085.3
申请日：2003-10-10
发明人： TSUBOUCHI, Hidetsugu , SASAKI, Hirofumi , KURODA, Hideaki , ITOTANI, Motohiro , HASEGAWA, Takeshi; Daiichiaijitsuhaitsu 607, , HARAGUCHI, Yoshikazu , KURODA, Takeshi , MATSUZAKI, Takayuki , TAI, Kuninori , KOMATSU, Makoto , MATSUMOTO, Makoto , HASHIZUME, Hiroyuki; Daiaparesu 1401, , TOMISHIGE, Tatsuo , SEIKE, Yuji , KAWASAKI, Masanori , SUMIDA, Takumi , MIYAMURA, Shin; 147-13, Mukaininokoshi,
IPC分类号： C07D498/04 , C07D498/20 , C07D519/00 , A61K31/424 , A61P31/06 , C07F7/08
CPC分类号： C07D498/04 , C07D498/20 , C07F7/0812
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公开(公告)号：EP3186240B1
公开(公告)日：2019-06-12
申请号：EP15763096.3
申请日：2015-08-28
发明人： SHIMIZU, Hiroshi , KAWANO, Yoshikazu , ISHIKAWA, Shunpei , UEMATSU, Yukitaka , SHINOHARA, Toshio , ITOTANI, Motohiro , HARAGUCHI, Yoshikazu , TAKEMURA, Isao , KANESHIGE, Atsunori , NAKAI, Yuya , HARIGUCHI, Norimitsu , HAYASHI, Yohei , MATSUMOTO, Makoto
IPC分类号： C07D401/14 , C07D215/227 , C07D401/06 , A61K31/4709 , A61P31/06
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公开(公告)号：EP2697232B1
公开(公告)日：2016-05-18
申请号：EP12723752.7
申请日：2012-04-13
发明人： KAWANO, Yoshikazu , HARAGUCHI, Yoshikazu , SASAKI, Hirofumi , UEMATSU, Yukitaka , TSUBOUCHI, Hidetsugu , YATA, Hiromi , SHIMIZU, Hiroshi , KOHASHI, Kazuho , ITOTANI, Motohiro , TAI, Kuninori , TAKEMURA, Isao , HAYASHI, Mikayo , HASHIZUME, Hiroyuki , MATSUBA, Miki , NAKAMURA, Izuru , CHEN, Xiuhao , MATSUMOTO, Makoto
IPC分类号： C07D498/04 , A61K31/5365 , A61P31/04 , A61P31/06
CPC分类号： C07D498/04
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7.发明公开2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS 有权2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物用于治疗肺结核
公开(公告)号：EP1678185A1
公开(公告)日：2006-07-12
申请号：EP04793412.0
申请日：2004-10-29
发明人： TSUBOUCHI, Hidetsugu , SASAKI, Hirofumi, 33-15, Aza Sanchochi, Kitamura , ITOTANI, Motohiro , HARAGUCHI, Yoshikazu , MIYAMURA, Shin, 147-13 Aza Kitakawamukai Ninokoshi , MATSUMOTO, Makoto , HASHIZUME, Hiroyuki , TOMISHIGE, Tatsuo, Grand Kawauchitower 310 , KAWASAKI, Masanori , OHGURO, Kinue , SUMIDA, Takumi , HASEGAWA, Takeshi, Dai-ichiaijitsuhaitsu 607 , TANAKA, Kazuho , TAKEMURA, Isao
IPC分类号： C07D498/04 , A61K31/41 , A61P31/00 , C07D263/00 , C07D235/00
CPC分类号： C07D498/04
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
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8.发明公开DIHYDROPHENAZINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME AND DRUG FOR TUBERCLE BACILLI AND ATYPICAL ACID-FAST BACILLI 失效二氢吩衍生物，方法及其和补救办法KNOLLENBAZILLEN和非典型酸抗性细菌
公开(公告)号：EP0773935A1
公开(公告)日：1997-05-21
申请号：EP96915201.0
申请日：1996-05-17
发明人： KIKUCHI, Mikio , ISHIKAWA, Hiroshi , HORIMOTO, Hideaki , TSUBOUCHI, Hidetsugu , SHITSUTA, Takuya , SASAKI, Hirofumi , ITOTANI, Motohiro
IPC分类号： C07D241
CPC分类号： C07D241/46
摘要： The present invention provides a novel dihydrophenazine derivative represented by general formula (1), wherein R1 is a lower alkyl group or a hydroxy-lower alkyl group, which has antibacterial and bactericidal activities to tubercle bacilli and a wide range of atypical acid-fast bacilli; and a pharmaceutically acceptable salt thereof.
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9.发明公开
公开(公告)号：EP3186240A1
公开(公告)日：2017-07-05
申请号：EP15763096.3
申请日：2015-08-28
发明人： SHIMIZU, Hiroshi , KAWANO, Yoshikazu , ISHIKAWA, Shunpei , UEMATSU, Yukitaka , SHINOHARA, Toshio , ITOTANI, Motohiro , HARAGUCHI, Yoshikazu , TAKEMURA, Isao , KANESHIGE, Atsunori , NAKAI, Yuya , HARIGUCHI, Norimitsu , HAYASHI, Yohei , MATSUMOTO, Makoto
IPC分类号： C07D401/14 , C07D215/227 , C07D401/06 , A61K31/4709 , A61P31/06
CPC分类号： C07D401/14 , C07D215/227 , C07D401/06
摘要： wherein each symbol is defined as described in the attached specification, or a salt thereof.
摘要翻译： 本发明的目的是提供对结核菌，耐多药结核菌和/或非结核分枝杆菌具有优异抗菌活性的化合物。 公开了通式（1）的化合物：其中每个符号如在所附说明书中所述定义，或其盐。
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10.发明授权
公开(公告)号：EP2467364B9
公开(公告)日：2015-02-18
申请号：EP10751720.3
申请日：2010-08-20
发明人： OSHIMA, Kunio , MATSUMURA, Shuuji , YAMABE, Hokuto , ISONO, Naohiro , TAKEMURA, Noriaki , TAIRA, Shinichi , OSHIYAMA, Takashi , MENJO, Yasuhiro , NAGASE, Tsuyoshi , UEDA, Masataka , KOGA, Yasuo , NAKAYAMA, Sunao , TSUJIMAE, Kenji , ONOGAWA, Toshiyuki , TAI, Kuninori , ITOTANI, Motohiro
IPC分类号： C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048 , C07D495/04 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/12 , C07D519/00 , C07D471/04 , C07D215/227
CPC分类号： C07D491/048 , C07D213/38 , C07D215/227 , C07D243/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
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