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    METHOD OF SEPARATING ISOMERS OF CHIRAL SUBSTANCES AND APPARATUS THEREFOR
    1.
    发明公开
    METHOD OF SEPARATING ISOMERS OF CHIRAL SUBSTANCES AND APPARATUS THEREFOR 有权
    用于手性分离物质及其装置的异构体的

    公开(公告)号：EP2218705A1

    公开(公告)日：2010-08-18

    申请号：EP08859898.2

    申请日：2008-12-12

    申请人： Osaka Prefecture University Public Corporation ,  Japan Science and Technology Agency

    发明人： ISHIHARA, Hajime ,  IIDA, Takuya ,  EGUCHI, Hiroki

    IPC分类号： C07B57/00 ,  B01D57/00 ,  B82B3/00 ,  C07D519/00 ,  C09B47/00

    CPC分类号： C07D519/00 ,  B01D57/00 ,  C07B57/00 ,  C09B47/00 ,  C09B67/0096 ,  C09B69/108 ,  C09B69/109

    摘要： In order to realize a method and an apparatus, each of which requires no contact treatment and no chemical reaction, for separating isomers of a chiral substance by irradiating a chiral substance C with light such as circularly polarized light, so as to separate isomers (C 1 and C 2 ) in accordance with a difference in acceleration between the isomers (C 1 and C 2 ), separation of isomers of a chiral substance in accordance with the present invention includes: (i) a circularly polarized light irradiating apparatus (3) for irradiating, with circularly polarized light, a chiral substance (C) which is a mixture of different isomers (C 1 and C 2 ) and is released from a molecular beam generating apparatus (2) in a vacuum chamber (1) and (ii) isomer inlets (1a and 1b) for separating the different isomers (C 1 and C 2 ) of the chiral substance (C) in accordance with a difference in acceleration between the different isomers (C 1 and C 2 ).

    摘要翻译： 为了实现一种方法和装置，其中的每一个非接触方式不通过化学反应，用于通过照射的手性物质C与光分离手性物质的异构体：如圆偏振光，以分离异构体（C 1和C 2）与异构体（C 1和C 2）中雅舞蹈与本发明手性物质的异构体的分离包括之间的加速度的差异雅舞蹈：（ⅰ）一个圆偏振光照射装置（3） 照射，以圆偏振光，手性物质（C），所有这些是不同异构体（C 1和C 2）的混合物中并从分子束发生装置释放（2）在真空室（1）和（ii ）异构体入口（1a和用于与不同的异构体C 1和C 2）之间的加速度的差异分离所述手性物质（C）（以雅舞蹈的不同异构体（C 1和C 2）1b）中。

    TARGET-SUBSTANCE DETECTION APPARATUS AND METHOD
    3.
    发明公开
    TARGET-SUBSTANCE DETECTION APPARATUS AND METHOD 有权
    ZIELSUBSTANZDETEKTIONSVORRICHTUNG UNDOVERHREN

    公开(公告)号：EP2993460A1

    公开(公告)日：2016-03-09

    申请号：EP14804538.8

    申请日：2014-05-30

    申请人： Osaka Prefecture University Public Corporation

    发明人： IIDA, Takuya ,  TOKONAMI, Shiho

    IPC分类号： G01N21/17 ,  G01N21/3577 ,  G01N21/41

    CPC分类号： G01N33/54346 ,  C12Q1/6834 ,  C12Q2563/155 ,  C12Q2565/628 ,  G01N21/21 ,  G01N21/554 ,  G01N21/658 ,  G01N33/5308 ,  G01N33/553 ,  G01N2201/061 ,  G01N2201/0683

    摘要： A detection device (100) detects an analyte that may be contained in a specimen. The detection device (100) includes a plurality of gold nanoparticles, an optical trapping light source (101), an illumination light source (102), an objective lens (103), an image pick-up device (108), and a computation unit (106). The plurality of gold nanoparticles are each modified with a probe DNA allowing the analyte to specifically adhere thereto. The optical trapping light source (101) emits polarized light for assembling the plurality of gold nanoparticles together. The objective lens (103) focuses and introduces the polarized light into a liquid containing a specimen and the plurality of gold nanoparticles. The image pick-up device (108) receives light from the liquid. The computation unit (106) detects an analyte based on a signal received from the image pick-up device (108).

    摘要翻译： 检测装置（100）检测可能包含在样本中的分析物。 检测装置（100）包括多个金纳米颗粒，光学捕获光源（101），照明光源（102），物镜（103），图像拾取装置（108）和计算 单元（106）。 多个金纳米颗粒各自用探针DNA修饰，使得分析物特异性地粘附于其上。 光捕获光源（101）发射用于将多个金纳米颗粒组装在一起的偏振光。 物镜（103）将偏振光聚焦并引入含有样品和多个金纳米颗粒的液体中。 摄像装置（108）从液体接收光。 计算单元（106）基于从图像拾取装置（108）接收的信号检测分析物。