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公开(公告)号：EP1341484A2
公开(公告)日：2003-09-10
申请号：EP01993238.3
申请日：2001-12-07
CPC分类号： A61F2/08
摘要： An implant for orthopedic applications includes a quantity of flexible, elongated elements at least some of which possess connective tissue-healing activity, the elongated elements being arranged in substantially common alignment along their longitudinal axis.
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公开(公告)号：EP1341484B1
公开(公告)日：2009-05-06
申请号：EP01993238.3
申请日：2001-12-07
CPC分类号： A61F2/08
摘要： An implant for orthopedic applications includes a quantity of flexible, elongated elements at least some of which possess connective tissue-healing activity, the elongated elements being arranged in substantially common alignment along their longitudinal axis.
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公开(公告)号：EP1328304A2
公开(公告)日：2003-07-23
申请号：EP01988599.5
申请日：2001-10-23
发明人： SHIMP, Lawrence, A.
CPC分类号： A61B17/7095 , A61B17/7097 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/64 , A61L2400/06 , A61L2430/38
摘要： A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support elements that are resistant to deformation or fracture under the normal physiologic loads to which the repair site is subject, the support elements being incorporable into the repair site, at least one osteoinductive susbtance and an amount of biocompatible carrier sufficient to render the augmentation composition flowable, the carrier having the capacity to be cleared from the repair site.
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公开(公告)号：EP1328304B1
公开(公告)日：2005-02-09
申请号：EP01988599.5
申请日：2001-10-23
发明人： SHIMP, Lawrence, A.
CPC分类号： A61B17/7095 , A61B17/7097 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/64 , A61L2400/06 , A61L2430/38
摘要： A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support elements that are resistant to deformation or fracture under the normal physiologic loads to which the repair site is subject, the support elements being incorporable into the repair site, at least one osteoinductive susbtance and an amount of biocompatible carrier sufficient to render the augmentation composition flowable, the carrier having the capacity to be cleared from the repair site.
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公开(公告)号：EP1408884A1
公开(公告)日：2004-04-21
申请号：EP02753372.8
申请日：2002-07-12
申请人： Osteotech, Inc., , Kaes, David R. , Morris, John W. , Shimp, Lawrence A. , Winterbottom, John , Geisler, Fred
CPC分类号： A61F2/28 , A61B17/86 , A61F2/30965 , A61F2/4455 , A61F2/446 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30131 , A61F2002/30176 , A61F2002/30354 , A61F2002/30405 , A61F2002/30492 , A61F2002/30578 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30836 , A61F2002/30841 , A61F2002/3085 , A61F2002/30904 , A61F2002/4475 , A61F2002/449 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0054 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00365
摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
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公开(公告)号：EP1494624B1
公开(公告)日：2010-06-30
申请号：EP03726166.6
申请日：2003-03-31
申请人： Osteotech, Inc.
CPC分类号： A61L27/3683 , A01N1/00 , A61F2/4644 , A61F2002/2835 , A61F2002/4645 , A61F2002/4649 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L2430/02 , A61L2430/40
摘要： The present invention relates to a method for making bone particles from bone of a variety of sizes and a workpiece forming and holding device for use with the method. The workpiece forming device includes a base and a base frame attached to the surface of the base. An apparatus for forming a solidified mass of bone and immobilization medium is also provided which includes the workpiece forming device and a detachable former member enclosing the base frame. Bone is immersed in an immobilization medium within such workpiece forming device, which is solidified to form a solidified mass of bone and immobilization medium and then subdivided to provide particles of bone in association to with immobilization medium. The immobilization medium may be optionally removed to leave bone particles suitable for use in orthopedic applications including implants.
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公开(公告)号：EP1589962A2
公开(公告)日：2005-11-02
申请号：EP04708211.0
申请日：2004-02-04
申请人： Osteotech, Inc.
IPC分类号： A61K31/26
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：EP1528938A2
公开(公告)日：2005-05-11
申请号：EP03785276.1
申请日：2003-08-12
申请人： Osteotech, Inc.
IPC分类号： A61L27/26
CPC分类号： A61L27/48 , A61L27/3608 , A61L27/46 , A61L2430/02 , C08L89/00
摘要： A method of producing a bone-polymer composite comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.
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公开(公告)号：EP1701672A2
公开(公告)日：2006-09-20
申请号：EP04815132.8
申请日：2004-12-20
申请人： Osteotech, Inc.
发明人： GEREMAKIS, Perry, A. , GRASSO, Jennifer , KNAACK, David , LIN, Jo-Wen , SHIMP, Lawrence, A. , WATERMAN, Robert , WINTERBOTTOM, John, M.
CPC分类号： A61L27/3641 , A61B17/06166 , A61B2017/00004 , A61F2/0063 , A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2/4601 , A61F2/4644 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61F2310/00011 , A61F2310/00179 , A61F2310/00359 , A61L27/3608 , A61L27/3633 , A61L27/3645 , A61L27/3804 , A61L27/3843 , B29C67/02
摘要： An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.
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公开(公告)号：EP1280564A2
公开(公告)日：2003-02-05
申请号：EP01935499.2
申请日：2001-05-14
申请人： Osteotech, Inc.,
发明人： EDWARDS, Jean, T. , SHIMP, Lawrence, A. , DIEGMANN, Michele , BOYCE, Todd, M. , SCARBOROUGH, Nelson, L. , RUSSELL, James, L.
IPC分类号： A61L27/36
CPC分类号： A61L27/3683 , A61L27/3608 , A61L27/365 , A61L2430/02
摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
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