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1.发明公开POLYMERASE ENZYMES AND REAGENTS FOR ENHANCED NUCLEIC ACID SEQUENCING 审中-公开聚合酶及试剂高级NUKEINSÄURESEQUENZIERUNG
公开(公告)号：EP2089517A4
公开(公告)日：2010-10-20
申请号：EP07867267
申请日：2007-10-22
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , BIBILLO AREK , HANZEL DAVID K , PELUSO PAUL , WEGENER JEFF
CPC classification number: C12N9/1252 , C12P19/34
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公开(公告)号：EP2029780A4
公开(公告)日：2010-03-31
申请号：EP07798630
申请日：2007-06-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LYLE JOHN , PELUSO PAUL , SHEN GENE
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q2561/113 , C12Q2525/186 , C12Q2523/313
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3.发明公开
公开(公告)号：EP1938099A4
公开(公告)日：2009-11-11
申请号：EP06815911
申请日：2006-09-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ROITMAN DANIEL BERNARDO , PELUSO PAUL , FOQUET MATHIEU
IPC: C12N11/14 , C07K17/14 , C12M1/00 , G01N33/552
CPC classification number: G01N33/54353 , G01N33/552
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公开(公告)号：EP1963530A4
公开(公告)日：2009-08-05
申请号：EP06848008
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
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Patent Agency Ranking5.发明公开ARTICLES HAVING LOCALIZED MOLECULES DISPOSED THEREON AND METHODS OF PRODUCING SAME 有权根据上述制造的事实ANGEORDETEN属地化分子和流程一文
公开(公告)号：EP2002019A4
公开(公告)日：2009-07-15
申请号：EP07754529
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF
CPC classification number: C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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6.发明公开PROTEIN ENGINEERING STRATEGIES TO OPTIMIZE ACTIVITY OF SURFACE ATTACHED PROTEINS 审中-公开蛋白生产策略来优化蛋白的活性表面与责任
公开(公告)号：EP1963501A4
公开(公告)日：2009-04-22
申请号：EP06848977
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFF , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12N9/22 , C07K2319/21 , Y10T428/2991 , Y10T428/2993 , Y10T428/2996 , Y10T428/31663 , Y10T428/31768
Abstract: Isolated and/or recombinant enzymes that include surface binding domains, surfaces with active enzymes bound to them and methods of coupling enzymes to surfaces are provided. Enzymes can include large and/or multiple surface coupling domains for surface coupling.
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公开(公告)号：EP2027253A4
公开(公告)日：2014-04-30
申请号：EP07845184
申请日：2007-06-11
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： FOQUET MATHIEU , PELUSO PAUL , TURNER STEPHEN , ROITMAN DANIEL BERNARDO , OTTO GEOFFREY
IPC: C12M3/00
CPC classification number: G02B6/10 , G01N21/648 , G01N2021/7713
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8.发明公开GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING 有权单分子测序法提高修饰聚合物的生成精度
公开(公告)号：EP2271751A4
公开(公告)日：2011-09-14
申请号：EP09755183
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： CLARK SONYA , BIBILLO AREK , PELUSO PAUL , CHRISTIANS FRED , HE MOLLY , PARK INSIL , LEE HAROLD , BJORNSON KEITH , JIA LEI , EMIG ROBIN
CPC classification number: C12N9/1252 , C12Q1/6844 , C12Q1/6869 , C12Q2521/101
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公开(公告)号：EP1963536A4
公开(公告)日：2010-03-03
申请号：EP06848948
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
IPC: C12Q1/68
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
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