公开(公告)号：EP2425023A4

公开(公告)日：2012-10-17

申请号：EP10772361

申请日：2010-04-26

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  SCHADT ERIC

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6869 ,  C12Q1/702 ,  C12Q2565/518 ,  C12Q2547/101

公开(公告)号：EP1963530A4

公开(公告)日：2009-08-05

申请号：EP06848008

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

IPC: C12Q1/68 ,  C12N11/14

CPC classification number: C12Q1/6837 ,  C07K2319/23 ,  C12N9/1252 ,  C12Q1/6844 ,  C12Q2521/101 ,  C12Q2565/531

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：EP2370598A4

公开(公告)日：2012-06-13

申请号：EP09832251

申请日：2009-12-10

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： FLUSBERG BENJAMIN ,  TURNER STEPHEN ,  LEE JESSICA ,  JIA LEI ,  KORLACH JONAS ,  SORENSON JON ,  WEBSTER DALE ,  LYLE JOHN ,  TRAVERS KEVIN ,  HANES JEREMIAH

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6869 ,  C12Q1/6837 ,  C12Q1/6858 ,  C12Q2561/113 ,  C12Q2537/164 ,  C12Q2527/113 ,  C12Q2521/101 ,  C12Q2525/307 ,  C12Q2525/117

公开(公告)号：EP2217928A4

公开(公告)日：2011-02-09

申请号：EP08856043

申请日：2008-12-03

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： KORLACH JONAS ,  ROITMAN DANIEL ,  EID JOHN ,  OTTO GEOFF ,  HARDENBOL PAUL ,  FLUSBERG BENJAMIN

IPC: G01N33/573 ,  B01L3/00 ,  C08G83/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/535 ,  G01N33/542 ,  G01N33/543 ,  G01N33/58

CPC classification number: G01N33/54373 ,  C12Q1/6874 ,  G01N33/542 ,  G01N33/54313 ,  G01N33/573 ,  G01N33/58 ,  G01N33/585 ,  C12Q2565/607 ,  C12Q2565/531 ,  C12Q2563/143 ,  C12Q2563/137

公开(公告)号：EP2331934A4

公开(公告)日：2015-04-01

申请号：EP09814888

申请日：2009-09-15

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： ZHONG CHENG FRANK ,  LUNDQUIST PAUL ,  FOQUET MATHIEU ,  KORLACH JONAS ,  BAYANDORIAN HOVIG

IPC: G01N21/64 ,  G01N21/77

CPC classification number: C12Q1/6874 ,  C12Q1/68 ,  C12Q1/6825 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/6463 ,  G01N2201/06113 ,  G01N2201/0638 ,  G01N2201/08

Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.

公开(公告)号：EP1790202A4

公开(公告)日：2013-02-20

申请号：EP05812440

申请日：2005-09-16

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： TURNER STEPHEN ,  KORLACH JONAS

IPC: C12Q1/68

CPC classification number: G01N21/6452 ,  B01L3/5085 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0896 ,  B82Y20/00 ,  B82Y30/00 ,  G02B6/13 ,  Y10T436/10

Abstract: The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.

Abstract translation: 本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。 本发明中体现的装置和方法对于高通量和低成本的单分子分析特别有用。

公开(公告)号：EP2286217A4

公开(公告)日：2011-05-25

申请号：EP09755181

申请日：2009-03-30

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： EID JOHN ,  TURNER STEPHEN ,  DALAL RAVI ,  FLUSBERG BENJAMIN ,  KORLACH JONAS ,  LIN STEVEN ,  FEHR ADRIAN ,  CHRISTIANS FRED ,  EMIG ROBIN

IPC: G01N33/48 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/52

CPC classification number: B01J19/0046 ,  B01J2219/00596 ,  C12N2310/50 ,  C12N2310/51 ,  C12Q1/6869 ,  C12Q2535/122 ,  C40B40/06 ,  G01N33/54313 ,  G01N33/54366

公开(公告)号：EP3332032A1

公开(公告)日：2018-06-13

申请号：EP16833794

申请日：2016-08-03

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： TURNER STEPHEN ,  KORLACH JONAS ,  WARREN STEVEN

IPC: C12Q1/68 ,  B01L3/00 ,  C12M1/34 ,  G01N27/22 ,  H01L31/109

CPC classification number: C12Q1/6869 ,  B82Y10/00 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  G01N27/4148 ,  G11C19/28 ,  H01L29/0669 ,  H01L29/0673 ,  H01L29/1606

Abstract: A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data.

公开(公告)号：EP2831283A4

公开(公告)日：2015-11-04

申请号：EP13769322

申请日：2013-03-18

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  CLARK TYSON A

IPC: C12Q1/68 ,  G01N33/48

CPC classification number: C12Q1/6869 ,  C12Q1/6827 ,  C12Q2535/122 ,  C12Q2537/164 ,  C12Q2521/514

公开(公告)号：EP2263087A4

公开(公告)日：2014-03-05

申请号：EP09719184

申请日：2009-03-12

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： WEGENER JEFFREY ,  KORLACH JONAS

IPC: G01N33/532 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/533 ,  G01N33/535

CPC classification number: C07H21/00 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q2563/107