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公开(公告)号：EP2797592B1
公开(公告)日：2019-08-28
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353 , C07D413/14 , C07D405/14 , C07D311/16 , C07D311/18 , C07D231/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00 , A61P25/00 , C07D417/14
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公开(公告)号：EP2797592A1
公开(公告)日：2014-11-05
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353
CPC分类号： C07D487/04 , C07D231/12 , C07D311/16 , C07D311/18 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.
摘要翻译： 本文提供了化合物，其组合物以及用于治疗脊髓性肌萎缩的用途。 在具体的实施方案中，本文提供了可用于调节SMN2的外显子7包含到从SMN2基因转录的mRNA中的形式的化合物。 在另一个具体的实施方案中，本文提供了可用于调节SMN1的外显子7包含到从SMN1基因转录的mRNA中的形式的化合物。 在又一个实施方案中，本文提供了可用于调节SMN1和SMN2的外显子7包含在分别从SMN1和SMN2基因转录的mRNA中的形式的化合物。
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3.发明公开
公开(公告)号：EP3071553A1
公开(公告)日：2016-09-28
申请号：EP13897883.8
申请日：2013-11-21
发明人： BAIAZITOV, Ramil , CHOI, Soongyu , DU, Wu , HWANG, Seongwoo , LEE, Chang-Sun , LIU, Ronggang , MOON, Young-Choon , PAGET, Steven D. , REN, Hongyu , SYDORENKO, Nadiya , WILDE, Richard Gerald
IPC分类号： C07D241/20
CPC分类号： C07D403/04 , A61K31/497 , A61K31/4985 , A61K31/519 , A61K31/69 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07F5/04
摘要： Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B -cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
摘要翻译： 胺取代的吡啶和吡嗪化合物及其形式，其抑制B细胞特异性莫洛尼鼠白血病病毒整合位点1（Bmi-1）蛋白的功能和水平降低，以及它们用于抑制Bmi-1功能和降低水平的方法 的Bmi-1治疗由Bmi-1介导的癌症。
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公开(公告)号：EP2819519A1
公开(公告)日：2015-01-07
申请号：EP13755032.3
申请日：2013-02-28
IPC分类号： A01N57/00
CPC分类号： C07D519/00 , C07D491/04 , C07D491/052
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
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公开(公告)号：EP2922828B1
公开(公告)日：2020-07-08
申请号：EP13857326.6
申请日：2013-11-21
发明人： LEE, Chang-Sun , BAIAZITOV, Ramil , CAO, Liangxian , DAVIS, Thomas, W. , DU, Wu , LIU, Ronggang , MOON, Young-choon , PAGET, Steven, D. , REN, Hongyu , SYDORENKO, Nadiya , WILDE, Richard, Gerald
IPC分类号： C07D403/12 , C07D403/04 , C07D471/04 , C07D487/04 , A61K31/506 , A61P35/00
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公开(公告)号：EP2922828A2
公开(公告)日：2015-09-30
申请号：EP13857326.6
申请日：2013-11-21
发明人： LEE, Chang-Sun , BAIAZITOV, Ramil , CAO, Liangxian , DAVIS, Thomas, W. , DU, Wu , LIU, Ronggang , MOON, Young-choon , PAGET, Steven, D. , REN, Hongyu , SYDORENKO, Nadiya , WILDE, Richard, Gerald
IPC分类号： C07D239/48
摘要： Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
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