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公开(公告)号：EP2797592B1
公开(公告)日：2019-08-28
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353 , C07D413/14 , C07D405/14 , C07D311/16 , C07D311/18 , C07D231/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00 , A61P25/00 , C07D417/14
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公开(公告)号：EP4219466A1
公开(公告)日：2023-08-02
申请号：EP23162466.9
申请日：2020-05-12
发明人： SYDORENKO, Nadiya , ALAM, Rauful , AMEDZO, Lukiana , ARNOLD, Michael A. , BABU, Suresh , BHATTACHARYYA, Anuradha , KARP, Gary Mitchell , KENTON, Nathaniel T. , LUONG, Tom Tuan , MAZZOTTI, Anthony R. , MOON, Young-Choon , MORRILL, Christie , MSZAR, Nicholas W. , NARASIMHAN, Jana , PATEL, Jigar S. , REN, Hongyu , TURPOFF, Anthony , WANG, Gang , WOLL, Matthew G. , ZHANG, Nanjing , ZHANG, Xiaoyan
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61K31/501 , A61K31/53 , A61P25/28
摘要： The present description relates to compounds (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.-
公开(公告)号：EP3814357A1
公开(公告)日：2021-05-05
申请号：EP19736566.1
申请日：2019-06-25
发明人： SYDORENKO, Nadiya , ALAM, Md Rauful , ARNOLD, Michael A. , BABU, Suresh , BHATTACHARYYA, Anuradha , CHEN, Guangming , GERASYUTO, Aleksey I. , KARP, Gary Mitchell , KASSICK, Andrew J. , MAZZOTTI, Anthony R. , MOON, Young-Choon , NARASIMHAN, Jana , PATEL, Jigar , TURPOFF, Anthony , WOLL, Matthew G. , YAN, Wuming , ZHANG, Nanjing
IPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00 , A61P25/00 , A61P25/14 , A61P25/28 , A61K31/4985 , A61K31/5025
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公开(公告)号：EP3644996A1
公开(公告)日：2020-05-06
申请号：EP18825111.0
申请日：2018-06-27
IPC分类号： A61K31/4353 , A61K31/4375 , A61K31/4545 , C07D401/00 , C07D401/14
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公开(公告)号：EP4244362A1
公开(公告)日：2023-09-20
申请号：EP21824134.7
申请日：2021-11-11
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公开(公告)号：EP3969446A1
公开(公告)日：2022-03-23
申请号：EP20729481.0
申请日：2020-05-12
发明人： SYDORENKO, Nadiya , ALAM, Md Rauful , AMEDZO, Lukiana , ARNOLD, Michael A. , BABU, Suresh , BHATTACHARYYA, Anuradha , KARP, Gary Mitchell , KENTON, Nathaniel T. , LUONG, Tom Tuan , MAZZOTTI, Anthony R. , MOON, Young-Choon , MORRILL, Christie , MSZAR, Nicholas Walter , NARASIMHAN, Jana , PATEL, Jigar S. , REN, Hongyu , TURPOFF, Anthony , WANG, Gang , WOLL, Matthew G. , ZHANG, Nanjing , ZHANG, Xiaoyan
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61K31/501 , A61K31/53 , A61P25/28
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公开(公告)号：EP4434990A1
公开(公告)日：2024-09-25
申请号：EP24168248.3
申请日：2019-06-25
发明人： SYDORENKO, Nadiya , ALAM, Rauful , ARNOLD, Michael A. , BABU, Suresh , BHATTACHARYYA, Anuradha , CHEN, Guangming , GERASYUTO, Aleksey I. , KARP, Gary Mitchell , KASSICK, Andrew J. , MAZZOTTI, Anthony R. , MOON, Young-Choon , NARASIMHAN, Jana , PATEL, Jigar , TURPOFF, Anthony , WOLL, Matthew G. , YAN, Wuming , ZHANG, Nanjing
IPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00 , A61P25/00 , A61P25/14 , A61P25/28 , A61K31/4985 , A61K31/5025
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00 , A61P25/00 , A61P25/14 , A61P25/28
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.-
公开(公告)号：EP2797592A1
公开(公告)日：2014-11-05
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353
CPC分类号： C07D487/04 , C07D231/12 , C07D311/16 , C07D311/18 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.
摘要翻译： 本文提供了化合物，其组合物以及用于治疗脊髓性肌萎缩的用途。 在具体的实施方案中，本文提供了可用于调节SMN2的外显子7包含到从SMN2基因转录的mRNA中的形式的化合物。 在另一个具体的实施方案中，本文提供了可用于调节SMN1的外显子7包含到从SMN1基因转录的mRNA中的形式的化合物。 在又一个实施方案中，本文提供了可用于调节SMN1和SMN2的外显子7包含在分别从SMN1和SMN2基因转录的mRNA中的形式的化合物。
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