公开(公告)号：EP1742637A2

公开(公告)日：2007-01-17

申请号：EP05856651.4

申请日：2005-04-25

申请人： Paratek Pharmaceuticals, Inc.

发明人： ALEKSHUN, Michael N. ,  AMOO, Victor ,  KIM, Oak K. ,  VERMA, Atul K

IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/4709 ,  A61K31/4439 ,  A61K31/42 ,  A61K31/427 ,  A61K31/4184

CPC分类号： A61K31/5377 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  C07D235/18 ,  C07D235/22 ,  C07D235/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/401 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483

摘要： Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

公开(公告)号：EP2139474A2

公开(公告)日：2010-01-06

申请号：EP08826039.3

申请日：2008-03-27

申请人： Paratek Pharmaceuticals, Inc.

发明人： GARRITY-RYAN, Lynne ,  GRIER, Mark ,  KIM, Oak, K. ,  LEVY, Stuart, B. ,  ALEKSHUN, Michael N. ,  BARTLETT, Victoria ,  DRAPER, Michael ,  GAY, Raina

IPC分类号： A61K31/4184 ,  A61K31/437 ,  A61K31/52 ,  A61P11/00 ,  A61P13/02 ,  A61P17/02 ,  A61P27/02 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00

CPC分类号： A61K31/4184 ,  A61K31/437 ,  A61K31/52

摘要： Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections.