公开(公告)号：EP1399414B1

公开(公告)日：2010-01-13

申请号：EP02723955.7

申请日：2002-04-24

申请人： Paratek Pharmaceuticals, Inc.

发明人： DRAPER, Michael ,  NELSON, Mark, L.

IPC分类号： C07C237/26 ,  A61P33/06

CPC分类号： A61K31/353 ,  A61K31/385 ,  A61K31/473 ,  A61K31/65 ,  Y02A50/411 ,  Y02A50/473 ,  A61K2300/00

摘要： Disclosed are substituted tyetracycline compounds, their use and pharmaceutical compositions comprising the compounds.

公开(公告)号：EP1381372A2

公开(公告)日：2004-01-21

申请号：EP02750617.9

申请日：2002-03-14

申请人： Paratek Pharmaceuticals, Inc.

发明人： DRAPER, Michael ,  NELSON, Mark, L.

IPC分类号： A61K31/65 ,  A61K31/70

CPC分类号： A61K45/06 ,  A61K31/65 ,  A61K31/7048 ,  A61K2300/00

摘要： Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.

公开(公告)号：EP3488853A1

公开(公告)日：2019-05-29

申请号：EP18193283.1

申请日：2007-12-21

申请人： Paratek Pharmaceuticals, Inc.

发明人： ASSEFA, Haregewein ,  BHATIA, Beena ,  DRAPER, Michael ,  MOLNAR, Dennis P. ,  KIM, Oak K. ,  HONEYMAN, Laura

IPC分类号： A61K31/65 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P43/00 ,  C07C237/26

摘要： Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.

公开(公告)号：EP2026776A2

公开(公告)日：2009-02-25

申请号：EP07809091.7

申请日：2007-05-15

申请人： Paratek Pharmaceuticals, Inc.

发明人： NELSON, Mark L. ,  DRAPER, Michael

IPC分类号： A61K31/00

CPC分类号： C12N15/635 ,  A61K31/65 ,  C12N15/85 ,  C12N2830/003

摘要： The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells. Use of certain substituted tetracycline compounds, as featured in the methods of the invention, result in improved dose-response results when compared to those for e.g., tetracycline and doxycycline. Certain methods of the invention thus allow for enhanced control of the Tet repressor/operator/inducer system in regulating gene expression in cells.

公开(公告)号：EP1562608A2

公开(公告)日：2005-08-17

申请号：EP03781397.9

申请日：2003-10-24

申请人： Paratek Pharmaceuticals, Inc.

发明人： LEVY, Stuart, B. ,  DRAPER, Michael ,  JONES, Graham ,  NELSON, Mark, L.

IPC分类号： A61K31/65

CPC分类号： C07C237/26 ,  A61K31/65

摘要： A method for modulating RNA with tetracycline compounds is described.

公开(公告)号：EP1556007A2

公开(公告)日：2005-07-27

申请号：EP03781398.7

申请日：2003-10-24

申请人： Paratek Pharmaceuticals, Inc.

发明人： DRAPER, Michael ,  NELSON, Mark, L.

IPC分类号： A61K9/02 ,  A61K9/48

CPC分类号： A61K31/65 ,  Y02A50/411 ,  A61K2300/00

摘要： This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.

公开(公告)号：EP2120963B1

公开(公告)日：2018-09-12

申请号：EP07870927.6

申请日：2007-12-21

申请人： Paratek Pharmaceuticals, Inc.

发明人： ASSEFA, Haregewein ,  BHATIA, Beena ,  DRAPER, Michael ,  HONEYMAN, Laura ,  MOLNAR, Dennis P. ,  KIM, Oak, K.

IPC分类号： A61K31/65 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P43/00 ,  C07C237/26

CPC分类号： C07C237/48 ,  A61K31/65 ,  C07C237/26 ,  C07C2603/46

摘要： Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.

公开(公告)号：EP1408987B1

公开(公告)日：2013-04-10

申请号：EP02748169.6

申请日：2002-07-15

申请人： Paratek Pharmaceuticals, Inc.

发明人： LEVY, Stuart, B. ,  DRAPER, Michael ,  NELSON, Mark, L. ,  JONES, Graham

IPC分类号： A61K31/70 ,  A61K9/28

CPC分类号： C07C237/36 ,  A61K31/65 ,  C07C2603/46 ,  Y02A50/411

摘要： 7-[(diethylamino)methyl]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10, 12,12a-tetrahydroxy-1,11,-dioxo-(4R,4aS,5aR,12aS)-2-Naphthacenecarboxamide of formula and its use in the treatment of human and veterinary infections.

摘要翻译： 7 - [（二乙基氨基）甲基] -4-（二甲基氨基）-1,4,4a，5,5a，6,11,12a-八氢-3,10,12,12a-四羟基-1,11-二氧代 - （4R，4aS，5aR，12aS）-2-萘并萘甲酰胺及其用于治疗人和兽医感染的用途。

公开(公告)号：EP2144614A1

公开(公告)日：2010-01-20

申请号：EP08742883.5

申请日：2008-04-14

申请人： Paratek Pharmaceuticals, Inc.

发明人： BERNIAC, Joel ,  BOWSER, Todd ,  DRAPER, Michael ,  LEVY, Stuart, B. ,  NELSON, Mark, L.

IPC分类号： A61K31/65 ,  A61P25/28

CPC分类号： A61K31/65

摘要： Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.

公开(公告)号：EP2139474A2

公开(公告)日：2010-01-06

申请号：EP08826039.3

申请日：2008-03-27

申请人： Paratek Pharmaceuticals, Inc.

发明人： GARRITY-RYAN, Lynne ,  GRIER, Mark ,  KIM, Oak, K. ,  LEVY, Stuart, B. ,  ALEKSHUN, Michael N. ,  BARTLETT, Victoria ,  DRAPER, Michael ,  GAY, Raina

IPC分类号： A61K31/4184 ,  A61K31/437 ,  A61K31/52 ,  A61P11/00 ,  A61P13/02 ,  A61P17/02 ,  A61P27/02 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00

CPC分类号： A61K31/4184 ,  A61K31/437 ,  A61K31/52

摘要： Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections.