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1.发明公开
公开(公告)号：EP1463726A2
公开(公告)日：2004-10-06
申请号：EP02796011.1
申请日：2002-12-23
发明人： CHANDRAKUMAR, Nizal, S. , DALTON, Christopher, R. , MALECHA, James, W. , TOLLEFSON, Michael, B. , VANCAMP, Jennifer, Ann , COX, Phillip, B.
IPC分类号： C07D409/12
CPC分类号： C07D319/08 , C07C323/41 , C07C323/42 , C07C2601/02 , C07C2601/04 , C07D213/32 , C07D311/16 , C07D317/56 , C07D317/64 , C07D333/38 , C07D409/12
摘要： The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula (I) and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula (I).
摘要翻译： 本发明涉及选择性LXR调节剂，对应于式I的小分子化合物，并且还涉及使用治疗有效剂量的式I化合物治疗由LXR调节的哺乳动物状况的方法。
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公开(公告)号：EP1542966A1
公开(公告)日：2005-06-22
申请号：EP03754739.5
申请日：2003-09-17
发明人： CHANDRAKUMAR, Nizal, S. , DALTON, Christopher, R. , MALECHA, James, W. , TOLLEFSON, Michael, B. , VANCAMP, Jennifer, Ann , COX, Phillip, B.
IPC分类号： C07C323/56 , C07C323/60 , C07C323/62 , C07D213/70 , C07D213/81 , C07D213/82 , C07D295/14 , C07D295/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/38 , A61K31/167 , A61P9/04
CPC分类号： C07D213/75 , C07C323/56 , C07C323/60 , C07C323/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/81 , C07D213/82 , C07D295/108 , C07D295/192 , C07D307/14 , C07D317/58 , C07D333/38
摘要： The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula (I) and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula (I).
摘要翻译： 本发明涉及选择性LXR调节剂，对应于式I的小分子化合物，并且还涉及使用治疗有效剂量的式I化合物治疗由LXR调节的哺乳动物状况的方法。
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公开(公告)号：EP1592421A1
公开(公告)日：2005-11-09
申请号：EP03800081.6
申请日：2003-12-22
发明人： BOYS, Mark, L. , SCHRETZMAN, Lori, A. , TOLLEFSON, Michael, B. , CHANDRAKUMAR, Nizal, S. , KHANNA, Ish, K. , NGUYEN, Maria , DOWNS, Victoria , MOHLER, Scott B. , GESICKI, Glen, J. , PENNING, Thomas, D. , CHEN, Barbara, B. , WANG, Yaping , KHILEVICH, Albert , DESAI, Bipinchandra, N. , YU, Yi , WENDT, John, A. , STENMARK, Heather , WU, Lisa , HUFF, Renee, M. , NAGARAJAN, Srinivasan R. , DEVADAS, Balekudru , LU, Hwang-Fun , RUSSELL, Mark , SPANGLER, Dale P. , PARIKH, Mihir D.
CPC分类号： A61K31/4245 , A61K31/4745
摘要： The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the ανβ3 and/or the ανβ5 integrin without significantly inhibiting the ανβ6 integrin.
摘要翻译： 本发明涉及包含式I化合物或其药学上可接受的盐的药物组合物，以及选择性抑制或拮抗αvβ3和/或αvβ5整联蛋白而不显着抑制αvβ6整联蛋白的方法。
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4.发明公开AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS 审中-公开芳香SULFONHYDROXAMSÄUREN及其使用蛋白酶抑制剂
公开(公告)号：EP1472244A1
公开(公告)日：2004-11-03
申请号：EP02789749.5
申请日：2002-11-19
发明人： BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , BOEHM, Terri, L. , CARROLL, Jeffery, N. , DECRESCENZO, Gary, A. , FOBIAN, Yvette, M. , FRESKOS, John, N. , GETMAN, Daniel, P. , HOCKERMAN, Susan, L. , HOWARD, Carol, Pearcy , KASSAB, Darren, J. , KOLODZIEJ, Steve, A. , LI, Madeleine, H. , MCDONALD, Joseph, J. , MISCHKE, Deborah, A. , RICO, Joseph, G. , STEHLE, Nathan, W. , TOLLEFSON, Michael, B. , VILLAMIL, Clara, I.
IPC分类号： C07D405/12 , C07D405/14 , C07D409/12 , C07D335/02 , C07D211/66 , C07D401/12 , C07D417/06 , C07D417/12 , C07D413/12
CPC分类号： C07D401/14 , C07D211/66 , C07D231/12 , C07D233/56 , C07D249/08 , C07D309/08 , C07D335/02 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention is directed to aromatic sulfone hydroxamates (also known as aromatic sulfone hydroxamic acids) and salts thereof that, inter alia, tend to inhibit matrix metalloproteinase (also known as matrix metalloprotease or MMP) activity and/or aggrecanase activity. This invention also is directed to a treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP activity and/or aggrecanase activity.
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5.发明公开
公开(公告)号：EP1289983A2
公开(公告)日：2003-03-12
申请号：EP01948424.5
申请日：2001-06-15
发明人： NAGARAJAN, Scrinivasan, Raj , KHANNA, Ish, Kumar , TOLLEFSON, Michael, B. , MOHLER, Scott, B. , CHEN, Barbara , RUSSELL, Mark , DEVADAS, Balekudru , PENNING, Thomas, D. , SCHRETZMAN, Lori, A. , SPANGLER, Dale, P. , BOYS, Mark, Laurence , CHANDRAKUMAR, Nizal, Samuel , LU, Hwang-Fun
IPC分类号： C07D413/12
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the αξβ3 and/or the αξβ5 integrin without significantly antagonizing the IIb/IIIa integrin.
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