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公开(公告)号：EP2741785A2
公开(公告)日：2014-06-18
申请号：EP12840108.0
申请日：2012-07-12
申请人： Philadelphia Health and Education Corporation , Inovio Pharmaceuticals, Inc. , The Trustees of the University of Pennsylvania
发明人： KUTZLER, Michele , BALIBAN, Scott , WEINER, David, B. , SARDESAI, Niranjan, Y. , KIM, J. Joseph
CPC分类号： A61K39/08 , A61K2039/53 , A61N1/327 , C07K14/33
摘要： The invention relates to compositions and methods for treating C. difficile associated disease (CD AD) through the administration to a subject in need thereof at least one nucleic acid encoding at least a portion of at least one of toxin A and toxin B.
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公开(公告)号：EP2741785B1
公开(公告)日：2018-09-05
申请号：EP12840108.0
申请日：2012-07-12
申请人： Philadelphia Health and Education Corporation , Inovio Pharmaceuticals, Inc. , The Trustees of The University of Pennsylvania
发明人： KUTZLER, Michele , BALIBAN, Scott , WEINER, David, B. , SARDESAI, Niranjan, Y. , KIM, J. Joseph
CPC分类号： A61K39/08 , A61K2039/53 , A61N1/327 , C07K14/33
摘要： The invention relates to compositions and methods for treating C. difficile associated disease (CDAD) through the administration to a subject in need thereof at least one nucleic acid encoding at least a portion of at least one of toxin A and toxin B.
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3.发明公开
公开(公告)号：EP3909973A3
公开(公告)日：2022-01-26
申请号：EP21175561.6
申请日：2011-11-14
发明人： WEINER, David, B. , YAN, Jian , FERRARO, Bernadette , SARDESAI, Niranjan, Y. , RAMANATHAN, Mathura, P.
摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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4.发明公开
公开(公告)号：EP3909973A2
公开(公告)日：2021-11-17
申请号：EP21175561.6
申请日：2011-11-14
发明人： WEINER, David, B. , YAN, Jian , FERRARO, Bernadette , SARDESAI, Niranjan, Y. , RAMANATHAN, Mathura, P.
摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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公开(公告)号：EP3074051A1
公开(公告)日：2016-10-05
申请号：EP14866748.8
申请日：2014-11-26
IPC分类号： A61K48/00 , A61K38/16 , A61K39/215 , A61K39/12
CPC分类号： A61K39/215 , A61K39/12 , A61K2039/53 , C12N7/00 , C12N2770/20034
摘要： Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.
摘要翻译： 本文公开了包含中东呼吸综合征冠状病毒（MERS-CoV）抗原的疫苗。 抗原可以是共有抗原。 共有抗原可以是共有的刺突抗原。 本文还公开的是通过将所述疫苗施用于受试者来治疗有需要的受试者的方法。
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公开(公告)号：EP2234624B1
公开(公告)日：2018-06-20
申请号：EP09707528.7
申请日：2009-01-12
IPC分类号： A61K31/70 , C12P19/34 , C12N7/01 , A61K39/295
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/394
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.
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7.发明授权ANTIGENS THAT ELICIT IMMUNE RESPONSE AGAINST FLAVIVIRUS AND METHODS OF USING SAME 有权抗原刺激免疫反应反对黄病毒及其使用方法
公开(公告)号：EP2358733B1
公开(公告)日：2015-07-08
申请号：EP09826953.3
申请日：2009-11-17
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/55527 , C12N2770/24134 , Y02A50/39 , Y02A50/394
摘要： Aspects of the present invention relate to isolated nucleic acids that encode a consensus DIII domain of protein E and vaccines made using same, and also methods for using the aforementioned to generate in a host an immune response against multiple serotypes of flavivirus, particularly West Nile virus and Japanese encephalitis virus.
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