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1.发明公开THIENOPYRROLE COMPOUNDS AND USES THEREOF AS INHIBITORS OF OPLOPHORUS-DERIVED LUCIFERASES 审中-公开噻吩并吡咯化合物及其用作OPLOPHORUS-DERIVED LUCIFERASES的抑制剂
公开(公告)号：EP3313846A1
公开(公告)日：2018-05-02
申请号：EP16736683.0
申请日：2016-06-24
申请人： Promega Corporation
IPC分类号： C07D493/04 , C07D495/04 , C07D209/42 , G01N33/58 , C12Q1/66 , C07K5/06
摘要： Thienopyrrole compounds that may inhibit Oplophorus-derived luciferases are disclosed, as well as compositions and kits comprising the thienopyrrole compounds, and methods of using the thienopyrrole compounds.
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2.发明公开OPLOPHORUS-DERIVED LUCIFERASES, NOVEL COELENTERAZINE SUBSTRATES, AND METHODS OF USE 有权荧光素酶OFF OPLOPHORUS，新COELENTERAZINSUBSTRATE和使用方法
公开(公告)号：EP2635595A2
公开(公告)日：2013-09-11
申请号：EP11785534.6
申请日：2011-11-02
申请人： Promega Corporation
发明人： BINKOWSKI, Brock , ENCELL, Lance, P. , HALL, Mary , ROBERS, Matthew, B. , SLATER, Michael, R. , WOOD, Keith, V. , WOOD, Monika, G.
IPC分类号： C07K14/435
CPC分类号： C12Q1/66 , A01K2217/072 , C07D487/04 , C12N9/0004 , C12N9/0069 , C12N15/52 , C12N2009/02 , C12Y113/12005 , C12Y113/12007
摘要： An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.
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公开(公告)号：EP3313846B1
公开(公告)日：2020-05-06
申请号：EP16736683.0
申请日：2016-06-24
申请人： Promega Corporation
IPC分类号： C07D493/04 , C07D495/04 , C07D209/42 , G01N33/58 , C12Q1/66 , C07K5/06
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公开(公告)号：EP2635595B1
公开(公告)日：2019-01-09
申请号：EP11785534.6
申请日：2011-11-02
申请人： Promega Corporation
发明人： BINKOWSKI, Brock , ENCELL, Lance, P. , HALL, Mary , ROBERS, Matthew, B. , SLATER, Michael, R. , WOOD, Keith, V. , WOOD, Monika, G. , KLAUBERT, Dieter , MEISENHEIMER, Poncho , UNCH, James , VALLEY, Michael P.
IPC分类号： C07K14/435
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