摘要:
Fungitoxic compositions exhibiting synergistic effects in the control of fungal growth are disclosed. The compounds are based on the combination of fatty acids and derivatives thereof with pyridazinones, and exhibit a greater than expected inhibitory effect against growth of fungi. The compounds are useful for agricultural applications including control of plant diseases, and also in control of mammalian fungal growth.
摘要:
This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula
wherein A is -(CHR²) n -CHR⁷-Z-; -(CHR²) n -O-Z-; -(CHR²) n -S-Z-; -O-CHR⁷-Z-; -CR²=CR⁷-Z-; -CR²=N-Z-; CHR²-CR⁷=Y-; or -CR²=CR²-Y=; D is CR² or nitrogen; Q is
Z is carbonyl (C=O) or thiocarbonyl (C=S); Y is carbon substituted with halo, alkoxy, alkynylthio or triazolyl; and either
(i) R¹ is alkyl, hydroxyalkyl, cyanoalkyl, hydrazidal and derivatives thereof, cycloalkylalkyl, heterocyclylalkyl, phenyl, phenylalkyl, phenylcarbonyl, alkenyl, haloalkenyl, phenylalkenyl, alkynylalkenyl, alkynyl, haloalkynyl, phenylalkynyl, heterocyclyl, dialkynyl, heterocyclylalkynyl, cycloalkylalkynyl, alkenylalkynyl, hydroxyalkynyl, alkoxyalkynyl, alkanoyloxyalkynyl, formylalkynyl, trialkylsilylalkynyl, trialkyltinalkynyl, haloalkenylalkynyl, carboxyalkynyl, or alkoxy-carbonylalkynyl; R² is hydrogen, (C₁-C₃)alkyl, phenyl, or halogen; R⁷ is hydrogen, (C₁-C₃)alkyl, phenyl, halogen, alkynylalkenyl, alkynyl, dialkynyl, haloalkynyl, or alkenylalkynyl; R³ and R⁶ are independently hydrogen, alkoxy or halogen; R⁴ is hydrogen, halogen, alkoxy or nitro; and R⁵ is hydrogen, halogen, nitro, alkyl, alkoxy, alkylthio, haloalkyl, haloalkoxy, haloalkylthio, phenyl, phenoxy or cyano; or alternatively (ii) R² and R³ together form a (C₁-C₃)alkyl, (C₂-C₃)alkylene or carbonyl link and R¹, R⁴, R⁵, R⁶ and R⁷ are as above; or alternatively (iii) R² and R⁷ together form a fused phenyl ring and R¹, R³, R⁴, R⁵ and R⁶ are as above; and agronomically acceptable salts thereof; compositions containing these compounds and methods of controlling fungal diseases.
摘要:
Fungitoxic compositions exhibiting synergistic effects in the control of fungal growth are disclosed. The compounds are based on the combination of fatty acids and derivatives thereof with pyridazinones, and exhibit a greater than expected inhibitory effect against growth of fungi. The compounds are useful for agricultural applications including control of plant diseases, and also in control of mammalian fungal growth.
摘要:
Certain cyclopropyl oxime ethers substituted by aryl and heterocyclic moieties possess broad spectrum fungicidal and insecticidal properties. These compounds are disclosed along with compositions containing these compounds and methods for controlling fungi and insects by the use of a fungitoxic or insecticidal amount of these compounds.
摘要:
Certain cyclopropyl oxime ethers substituted by aryl and heterocyclic moieties possess broad spectrum fungicidal and insecticidal properties. These compounds are disclosed along with compositions containing these compounds and methods for controlling fungi and insects by the use of a fungitoxic or insecticidal amount of these compounds.
摘要:
A process for novel sphingolipids and other secondary sphingosine-based compounds is provided which comprises the culturing of an appropriate fungus, harvesting mycelium from the fungus and isolating the sphingolipid from the mycelium. The sphingosine-based materials inhibit protein kinase C, provide an anti-inflammatory effect or provide an anti-tumor effect; furthermore, these sphingosine-based materials provide protection for plants against pathogenic microorganisms.
摘要:
A process for novel sphingolipids and other secondary sphingosine-based compounds is provided which comprises the culturing of an appropriate fungus, harvesting mycelium from the fungus and isolating the sphingolipid from the mycelium. The sphingosine-based materials inhibit protein kinase C, provide an anti-inflammatory effect or provide an anti-tumor effect; furthermore, these sphingosine-based materials provide protection for plants against pathogenic microorganisms.