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公开(公告)号：EP3116858B1
公开(公告)日：2020-11-11
申请号：EP15760744.1
申请日：2015-03-16
申请人： RaQualia Pharma Inc.
发明人： SHISHIDO, Yuji , OHMI, Masashi , ANDO, Kazuo
IPC分类号： C07D235/02 , A61K31/506 , A61K31/501 , A61K31/4985 , A61K31/498 , A61K31/497 , A61K31/4709 , A61K31/4439 , A61K31/4375 , A61K31/437 , A61K31/427 , A61K31/421 , A61K31/4166 , A61K31/4164 , A61K31/41 , A61P13/02 , A61P11/00 , A61P1/00 , A61P9/10
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公开(公告)号：EP3350171A1
公开(公告)日：2018-07-25
申请号：EP16843958.6
申请日：2016-09-12
申请人： RaQualia Pharma Inc.
发明人： SHISHIDO, Yuji , OHMI, Masashi
IPC分类号： C07D235/12 , A61K31/4184 , A61K31/437 , A61K31/501 , A61P1/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P25/00 , A61P29/00 , A61P37/02 , A61P43/00 , C07D403/12 , C07D471/04
CPC分类号： C07D403/12 , A61K31/4184 , A61K31/437 , A61K31/501 , A61K45/06 , C07D403/10 , C07D471/04 , A61K2300/00
摘要： The present invention relates to imidazolinone derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
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公开(公告)号：EP2424517A1
公开(公告)日：2012-03-07
申请号：EP10769531.4
申请日：2010-05-06
申请人： RaQualia Pharma Inc
IPC分类号： A61K31/18 , A61K31/196 , A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/495 , A61K31/5375 , A61K31/5377 , A61P1/04 , A61P9/10 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P13/12
CPC分类号： C07C311/21 , A61K31/18 , A61K31/196 , A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/495 , A61K31/5375 , A61K31/5377 , A61K45/06 , C07D213/42 , C07D213/75 , C07D295/13 , C07D295/185 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , A61K2300/00
摘要： The present invention relates to sulfamoyl benzoic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
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4.发明公开NOVEL PYRAZOLE-3-CARBOXAMIDE DERIVATE HAVING 5-HT2B RECEPTOR ANTAGONIST ACTIVITY 有权具有5-HT2B受体拮抗剂活性的新型吡唑-3-甲酰胺衍生物
公开(公告)号：EP2386546A1
公开(公告)日：2011-11-16
申请号：EP09827639.7
申请日：2009-11-24
申请人： RaQualia Pharma Inc
IPC分类号： C07D231/14 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/553 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/12 , A61P1/16 , A61P3/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/02
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/553 , C07D231/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as a selective antagonist of a 5-HT2 B receptor. The compound and salt are useful for treatment or prevention of various diseases and conditions associated with a 5-HT2 B receptor.
摘要翻译： 公开了由通式（I）表示的化合物或其药学上可接受的盐，其可用作5-HT2B受体的选择性拮抗剂。 该化合物和盐可用于治疗或预防与5-HT2B受体有关的各种疾病和病症。
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公开(公告)号：EP3487839A1
公开(公告)日：2019-05-29
申请号：EP18815499.1
申请日：2018-06-20
申请人： RaQualia Pharma Inc.
IPC分类号： C07D213/81 , A61K31/444 , A61K31/506 , A61P1/00 , A61P1/18 , A61P19/02 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , C07D239/42 , C07D401/12
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公开(公告)号：EP3676248A1
公开(公告)日：2020-07-08
申请号：EP18852154.6
申请日：2018-08-31
发明人： KAWAMURA, Kiyoshi , YAMAGISHI, Tatsuya , SHISHIDO, Yuji , MORITA, Mikio , YAMAGUCHI, Ryuichi , OHMI, Masashi
IPC分类号： C07C311/51 , A61K31/18 , A61K31/397 , A61K31/415 , A61K31/42 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4965 , A61K31/505 , A61K31/506 , A61K31/535 , A61P29/00 , C07D205/04 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/74
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公开(公告)号：EP3116858A1
公开(公告)日：2017-01-18
申请号：EP15760744.1
申请日：2015-03-16
申请人： RaQualia Pharma Inc.
发明人： SHISHIDO, Yuji , OHMI, Masashi , ANDO, Kazuo
IPC分类号： C07D235/02 , A61K31/41 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/427 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/506 , A61P1/00 , A61P9/10 , A61P11/00 , A61P13/02
摘要： The present invention relates to azaspiro derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
摘要翻译： 本发明涉及式（I）的氮杂螺旋衍生物或其药学上可接受的盐或其前药，其制备方法，含有它们的药物组合物以及它们在治疗通过TRPM8受体介导的各种疾病中的用途。
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8.发明授权NOVEL PYRAZOLE-3-CARBOXAMIDE DERIVATE HAVING 5-HT2B RECEPTOR ANTAGONIST ACTIVITY 有权具有5-HT2B受体拮抗剂活性的新型吡唑-3-甲酰胺衍生物
公开(公告)号：EP2386546B1
公开(公告)日：2015-08-19
申请号：EP09827639.7
申请日：2009-11-24
申请人： RaQualia Pharma Inc
IPC分类号： C07D231/14 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/553 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/12 , A61P1/16 , A61P3/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/02
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/553 , C07D231/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D471/04
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