公开(公告)号：EP2139334A1

公开(公告)日：2010-01-06

申请号：EP08742430.5

申请日：2008-03-31

申请人： Renovis, Inc.

发明人： WEI, Zhi-Liang ,  DUNCTON, Matthew, Alexander, James ,  KINCAID, John ,  KELLY, Michael G. ,  O'MAHONY, Donogh ,  WANG, Zhan

IPC分类号： A01N43/90 ,  A61K31/517 ,  C07D471/04

CPC分类号： C07D471/04 ,  C07D519/00

摘要： Fused heterocyclic compounds are provided according to formula (1): where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

公开(公告)号：EP1933622A2

公开(公告)日：2008-06-25

申请号：EP07753368.5

申请日：2007-03-16

申请人： Renovis, Inc.

发明人： KELLY, Michael G. ,  KINCAID, John ,  FANG, Yunfeng ,  CAO, Yeyu ,  KAUB, Carl ,  GOWLUGARI, Sumithra ,  WANG, Zhan

IPC分类号： A01N43/40

CPC分类号： C07D217/24 ,  C07D401/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following formula (I): the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

摘要翻译： 公开了具有由下式（I）表示的式的双环杂芳基化合物：所述化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括通过非 - 限制性例子，疼痛，炎症，创伤性损伤等。

公开(公告)号：EP2262766A2

公开(公告)日：2010-12-22

申请号：EP09716825.6

申请日：2009-02-27

申请人： Renovis, Inc.

发明人： WEI, Zhi-Liang ,  GOWLUGARI, Sumithra ,  KAUB, Carl ,  WANG, Zhan ,  CAO, Yeyu ,  KINCAID, John

IPC分类号： C07D205/04 ,  C07D213/56 ,  C07D213/61 ,  C07D215/12 ,  C07D231/12 ,  C07D231/16

CPC分类号： C07D213/64 ,  C07C69/78 ,  C07C233/69 ,  C07C317/32 ,  C07D205/04 ,  C07D207/06 ,  C07D213/56 ,  C07D213/61 ,  C07D213/643 ,  C07D215/12 ,  C07D231/12 ,  C07D231/16 ,  C07D239/26 ,  C07D239/34 ,  C07D239/47 ,  C07D241/12 ,  C07D249/08 ,  C07D263/56 ,  C07D265/36 ,  C07D277/28 ,  C07D277/30 ,  C07D295/104 ,  C07D317/48 ,  C07D333/54 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D489/04

摘要： Compounds are provided according to formula (1 ) : where A, B, W, X', L, R
1 , R
3 , R
4b , and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

公开(公告)号：EP2001474A2

公开(公告)日：2008-12-17

申请号：EP07753335.4

申请日：2007-03-16

申请人： Renovis, Inc.

发明人： KELLY, Michael, G. ,  KINCAID, John ,  FANG, Yunfeng ,  CAO, Yeyu ,  KAUB, Carl ,  GOWLUGARI, Sumithra ,  WANG, Zhan

IPC分类号： A61K31/4704 ,  C07D217/22

CPC分类号： C07D217/22 ,  C07D217/24 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

公开(公告)号：EP2124562A1

公开(公告)日：2009-12-02

申请号：EP08726672.2

申请日：2008-03-07

申请人： Renovis, Inc.

发明人： KELLY, Michael, G. ,  KINCAID, John ,  FANG, Yunfeng ,  CAO, Yeyu ,  KAUB, Carl ,  GOWLUGARI, Sumithra ,  WANG, Zhan

IPC分类号： A01N43/42 ,  A61K31/47

CPC分类号： C07D217/24 ,  C07D401/04 ,  C07D401/06

摘要： Compounds are disclosed that have a formula represented by the following fomula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

摘要翻译： 公开了具有由以下式（I）表示的式的化合物。 所述化合物可制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物的各种病症，包括非限制性实例，疼痛，炎症，创伤性损伤等。

公开(公告)号：EP1996585A2

公开(公告)日：2008-12-03

申请号：EP07753312.3

申请日：2007-03-16

申请人： Renovis, Inc.

发明人： KELLY, Michael, G. ,  KINCAID, John ,  FANG, Yunfeng ,  CAO, Yeyu ,  KAUB, Carl ,  GOWLUGARI, Sumithra ,  WANG, Zhan

IPC分类号： C07D471/02 ,  C07D487/02 ,  A61K31/4745 ,  A61K31/519

CPC分类号： C07D401/04 ,  C07D217/24 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D453/02

摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

摘要翻译： 公开了双环杂芳基化合物，其具有由下式表示的式：式（I）。 所述化合物可制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物的各种病症，包括非限制性实例，疼痛，炎症，创伤性损伤等。