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    Processing units and methods for the processing of liquid samples
    2.
    发明公开
    Processing units and methods for the processing of liquid samples 审中-公开
    Verarbeitungseinheiten und Verfahren zur Verarbeitung vonflüssigenProben

    公开(公告)号：EP2311563A1

    公开(公告)日：2011-04-20

    申请号：EP09167521.5

    申请日：2009-08-07

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Jaeggi, Rainer D. ,  Gutmann, Oliver ,  Oosterbroek, Edwin ,  Glauser, Michael ,  Heinrich, Michael ,  Bollinger, Jean-Pierre ,  Sarofim, Emad

    IPC分类号： B01L3/00

    CPC分类号： G01N35/1072 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0622 ,  B01L2400/0677 ,  G01N2035/00158 ,  Y10T436/2575

    摘要： The present invention relates to a microfluidic processing unit for the automated processing of liquid samples, comprising: at least one first and one second main channel connected to a pump for generating a negative or positive pressure therein; at least one sample channel for supplying liquid sample connectable to a sample vessel containing said liquid sample, said sample channel communicating with said first main channel and being equipped with an on/off valve; one or more reagent channels for supplying one or more reagents, said reagent channels being connectable to reagent vessels containing reagents for reacting with said liquid samples, each of said reagent channels communicating with said first or second main channel and being equipped with an on/off valve; at least one reaction chamber for reaction of sample and reagent to take place, said reaction chamber being connected to said first and second main channels via at least one on/off valve. It further relates to a microfluidic processing unit for the automated processing of liquid samples, comprising at least one set of first and second segments, each of which including: at least one first and one second main channel connected to a pump for generating a negative or positive pressure therein; at least one sample channel for supplying said liquid sample communicating with said first main channel and equipped with an on/off valve; one or more reagent channels for supplying reagents, said reagent channels being connectable to reagent vessels containing reagents for reacting with said liquid samples, each of said reagent channels communicating with said first or second main channel and being equipped with an on/off valve; at least one reaction chamber for reaction of sample and reagent to take place, said reaction chamber being connected to said first and second main channels via at least one on/off valve; wherein said second main channel of said first segment is being connected to said sample channel of said second segment. It yet further relates to methods for operating the processing units.

    摘要翻译： 本发明涉及一种用于液体样品的自动处理的微流体处理单元，包括：连接到泵的至少一个第一和第二主通道，用于在其中产生负压或正压; 用于供应液体样品的至少一个样品通道，其可连接到包含所述液体样品的样品容器，所述样品通道与所述第一主通道连通并且配备有开关阀; 用于供应一种或多种试剂的一个或多个试剂通道，所述试剂通道可连接到含有用于与所述液体样品反应的试剂的试剂容器，每个所述试剂通道与所述第一或第二主通道连通并且装备有开/关 阀; 至少一个用于使试样和试剂发生反应的反应室，所述反应室经由至少一个开/关阀连接到所述第一和第二主通道。 它还涉及一种用于液体样品的自动化处理的微流体处理单元，包括至少一组第一和第二段，每组包括：连接到泵的至少一个第一和第二主通道，用于产生负的或 正压; 至少一个样品通道，用于供应与所述第一主通道连通并配备有开/关阀的所述液体样品; 用于供应试剂的一个或多个试剂通道，所述试剂通道可连接到含有用于与所述液体样品反应的试剂的试剂容器，每个所述试剂通道与所述第一或第二主通道连通并且装有开关阀; 至少一个用于使样品和试剂发生反应的反应室，所述反应室经由至少一个开/关阀连接到所述第一和第二主通道; 其中所述第一段的所述第二主通道连接到所述第二段的所述采样通道。 它还涉及用于操作处理单元的方法。

    Fluidic systems, fluid containers and processes for washing fluid lines
    5.
    发明公开
    Fluidic systems, fluid containers and processes for washing fluid lines 有权
    Fluidsysteme，Fluidbehälterund Verfahren zum Waschen von Fluidleitungen

    公开(公告)号：EP2466316A1

    公开(公告)日：2012-06-20

    申请号：EP10195180.4

    申请日：2010-12-15

    申请人： F.Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Glauser, Michael ,  Jaeggi, Rainer D. ,  Hein, Heinz-Michel

    IPC分类号： G01N35/08 ,  G01N35/10

    CPC分类号： G01N35/1004 ,  G01N35/08

    摘要： The present invention pertains a process for automatically washing fluid lines of a fluidic system for combining liquid samples with one or more reagents, said system being provided with at least one main line connected to one or more reagent lines for feeding reagents, each of which being connectable to a reagent container by a fluidic connector, at least one sample intake for intaking samples and at least one pressure actuator for generating a positive or negative pressure in said fluid lines. The comprises one or more procedures selected from: procedure I: drawing wash fluid from a wash fluid reservoir connected to said main line into said main line and discharging wash fluid into a waste compartment for receiving waste fluid of a cleaning container connected to at least one reagent line (8) by said fluidic connector; procedure II: drawing wash fluid from at least one fluid compartment containing wash fluid of at least one cleaning container connected to at least one reagent line by said fluidic connector into said main line and discharging wash fluid from said main line into at least one waste compartment for receiving waste fluid of said cleaning container; procedure III: drawing wash fluid from at least one fluid compartment containing wash fluid of a cleaning container connected to at least one first reagent line into said main line and discharging wash fluid from said main line into at least one waste compartment for receiving waste fluid of a cleaning container connected to at least one second reagent line being different from said at least one first reagent line.

    摘要翻译： 本发明涉及一种自动清洗用于将液体样品与一种或多种试剂组合的流体系统的流体管线的方法，所述系统设置有至少一条连接到一个或多个试剂管线的主线，用于进料试剂，每个试剂管线为 可通过流体连接器连接到试剂容器，用于吸入样品的至少一个样品入口和用于在所述流体管线中产生正压或负压的至少一个压力致动器。 该方法包括一个或多个选自以下程序：步骤I：将连接到所述主管线的洗涤流体储存器洗涤流体进入所述主管线并将洗涤流体排放到废物室中，以接收与至少一个连接的清洁容器的废液 所述流体连接器的试剂管线（8） 程序II：将至少一个含有至少一个清洁容器的清洗流体的洗涤液从所述流体连接器连接到至少一个试剂管线进入所述主管线，并将洗涤液体从所述主管线排出到至少一个废物室 用于接收所述清洁容器的废液; 步骤III：从至少一个含有与至少一个第一试剂管线连接的清洗容器的清洗流体到所述主管线的洗涤流体洗涤流体，并将洗涤液体从所述主管线排出到至少一个废物隔室中， 与至少一个不同于所述至少一个第一试剂管线的第二试剂管线连接的清洁容器。