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1.发明公开COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME 审中-公开VON EINEM AMINKERNABKÖMMLICHEVERBINDUNGEN DIE IMPDH-ENZYME HEMMEN
公开(公告)号：EP1126843A4
公开(公告)日：2005-06-15
申请号：EP99955142
申请日：1999-10-22
发明人： LIU CHUNJIAN , DHAR T G MURALI , GU HENRY H , IWANOWICZ EDWIN J , LEFTHERIS KATERINA , PITTS WILLIAM JOHN
IPC分类号： A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/513 , A61K31/53 , A61K31/5377 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07D263/32 , C07D263/48 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D263/32 , C07D263/48 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.
摘要翻译： 本发明公开了IMPDH（肌苷-5'-单磷酸脱氢酶）的新型抑制剂的鉴定。 本文公开的化合物和药物组合物可用于治疗或预防IMPDH介导的疾病，例如移植排斥和自身免疫性疾病。
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公开(公告)号：EP1397142A4
公开(公告)日：2004-11-03
申请号：EP02744381
申请日：2002-06-17
发明人： GUO JUNQING , BARBOSA JOSEPH , PITTS WILLIAM JOHN , CARLSEN MARIANNE , QUESNELLE CLAUDE , DODIER MARCO
IPC分类号： C07D491/113 , A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/538 , A61K31/5513 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , A61K31/55 , C07D239/42 , C07D403/04
CPC分类号： C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
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公开(公告)号：EP1383743A4
公开(公告)日：2006-04-12
申请号：EP02725882
申请日：2002-04-30
发明人： PITTS WILLIAM JOHN , WATSON ANDREW J , DODD JOHN H
IPC分类号： A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/55 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/08 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , C07D211/00
CPC分类号： C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
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