公开(公告)号：EP3231867A1

公开(公告)日：2017-10-18

申请号：EP15867698.1

申请日：2015-12-08

申请人： Sapporo Medical University ,  Sumitomo Dainippon Pharma Co., Ltd.

发明人： SATO, Noriyuki ,  TORIGOE, Toshihiko ,  HIROHASHI, Yoshihiko ,  KANASEKI, Takayuki ,  MIYAMOTO, Sho ,  KOCHIN, Vitaly ,  GOTO, Masashi

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  C07K7/06 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/572 ,  C07K7/06 ,  C07K16/2833 ,  C07K16/30 ,  C07K2317/34 ,  C12N5/0638 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/15 ,  G01N33/50 ,  G01N33/5088 ,  G01N33/574 ,  G01N2333/46

摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by Y o -X o -Z o ; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.

摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 肿瘤干细胞特异性表达的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，所述药物组合物包含上述肿瘤抗原肽作为活性成分; 筛选肿瘤抗原肽的方法; 为实现上述目的，提供了：由Yo-Xo-Zo代表的肽; 由多个连接在一起的表位肽组成的多表位肽，所述多表位肽含有至少一种上述肽作为表位肽之一; 编码上述肽和/或多表位肽的多核苷酸; 包含其作为活性成分的药物组合物; 特征在于诱导CTL的癌症的预防和/或治疗剂; 等等