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公开(公告)号：EP3231867A1
公开(公告)日：2017-10-18
申请号：EP15867698.1
申请日：2015-12-08
发明人： SATO, Noriyuki , TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , KANASEKI, Takayuki , MIYAMOTO, Sho , KOCHIN, Vitaly , GOTO, Masashi
IPC分类号： C12N15/09 , A61K39/00 , A61K48/00 , A61P35/00 , C07K7/06 , C07K16/30 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574
CPC分类号： A61K39/0011 , A61K39/00 , A61K48/00 , A61K2039/572 , C07K7/06 , C07K16/2833 , C07K16/30 , C07K2317/34 , C12N5/0638 , C12N15/09 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/15 , G01N33/50 , G01N33/5088 , G01N33/574 , G01N2333/46
摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by Y o -X o -Z o ; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.
摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 肿瘤干细胞特异性表达的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，所述药物组合物包含上述肿瘤抗原肽作为活性成分; 筛选肿瘤抗原肽的方法; 为实现上述目的，提供了：由Yo-Xo-Zo代表的肽; 由多个连接在一起的表位肽组成的多表位肽，所述多表位肽含有至少一种上述肽作为表位肽之一; 编码上述肽和/或多表位肽的多核苷酸; 包含其作为活性成分的药物组合物; 特征在于诱导CTL的癌症的预防和/或治疗剂; 等等
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2.发明公开POTENTIATION OF CELLULAR IMMUNITY USING HISTONE DEACETYLASE (HDAC) INHIBITORS 审中-公开细胞免疫与组蛋白脱乙酰酶（HDAC）抑制剂加固
公开(公告)号：EP2091525A1
公开(公告)日：2009-08-26
申请号：EP07850583.1
申请日：2007-12-06
IPC分类号： A61K31/19 , C07C53/128 , A61P31/00
CPC分类号： A61K31/19 , G01N33/6893 , G01N2333/70539 , G01N2333/916 , Y02A50/463
摘要： [Technical Problem] The present invention provides an enhancer of cellular immunity, and provides applications to carcinogenesis or preventive therapy against cancer recurrence, immunotherapy for cancer, treatment for pathogenic microorganism infection, and the like. [Technical Solution] The present invention comprises the substance having an inhibitory activity of histone deacetylase (HDAC) as an active component.
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公开(公告)号：EP3054010B1
公开(公告)日：2020-07-22
申请号：EP14850688.4
申请日：2014-10-03
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公开(公告)号：EP3199627A1
公开(公告)日：2017-08-02
申请号：EP15843390.4
申请日：2015-09-24
发明人： TORIGOE, Toshihiko , ATSUYAMA, Eri , OTAKA, Hironori , NAKANO, Kazue , LI, Dongliang , TOJI, Shingo , ASANO, Takuya , HORIBE, Ryota , HIROHASHI, Yoshihiko , SATO, Noriyuki , SAITO, Tsuyoshi
IPC分类号： C12N15/00 , A61K35/76 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/04 , C07K7/06 , C12N5/10 , C12N15/09 , C07K14/82
CPC分类号： C07K14/4703 , A61K35/76 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K14/70539 , C07K14/82 , C07K16/18 , C07K16/30 , C12N5/0634 , C12N5/0638 , C12N5/10 , C12N15/00 , C12N15/09 , C12N2510/00 , G01N33/57496 , G01N2333/4704
摘要： The object is to provide a tumor antigen peptide that is specifically presented on a cancer and a cancer stem cell, and a pharmaceutical composition, etc. that is useful for the prevention and/or treatment of a cancer and contains the above peptide as an active ingredient.
The above object has been accomplished by providing a BORIS-derived partial peptide belonging to isoform A or C or subfamily 5 or 6, a polynucleotide encoding the peptide, a pharmaceutical composition containing the above as an active ingredient, and an agent for the prevention and/or treatment of a cancer, the agent containing the above as an active ingredient and inducing CTLs.摘要翻译： 本发明的目的在于提供可用于癌症的预防和/或治疗的含有上述肽作为有效成分的癌症和癌干细胞上特异性表达的肿瘤抗原肽和药物组合物等 成分。 上述目的通过提供属于同种型A或C或亚科5或6的BORIS衍生的部分肽，编码该肽的多核苷酸，含有上述作为活性成分的药物组合物，以及用于预防和 /或治疗癌症，包含上述作为活性成分并诱导CTL的试剂。
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公开(公告)号：EP3054010A1
公开(公告)日：2016-08-10
申请号：EP14850688.4
申请日：2014-10-03
发明人： SATO, Noriyuki , TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , KANASEKI, Takayuki , KOCHIN, Vitaly , TAKAYA, Akari , GOTO, Masashi
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K16/28 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574
摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting cancer stem cells; a tumor antigen peptide specifically exhibited by cancer stem cells; a pharmaceutical composition for the prevention and/or treatment of cancer, containing same as an effective component thereof; and a method for screening said tumor antigen peptide. A peptide indicated by YO-XO-ZO, a polyepitope peptide including at least one said peptide as an epitope peptide and having a plurality of epitope peptides joined therein, a polynucleotide that codes at least either the peptide or the polyepitope peptide, a pharmaceutical composition containing these as an effective component thereof, and a cancer prevention and/or treatment agent characterized by inducing CTLs.
摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 癌症干细胞特异表现的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，其含有作为其有效成分的药物组合物; 和筛选所述肿瘤抗原肽的方法。 由YO-XO-ZO表示的肽，包含至少一种所述肽作为表位肽并且具有连接在其中的多个表位肽的多表位肽，编码至少肽或多表位肽的多核苷酸，药物组合物 含有这些作为其有效成分的化合物，以及以诱导CTL为特征的癌症预防和/或治疗剂。
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公开(公告)号：EP2193807A1
公开(公告)日：2010-06-09
申请号：EP08828474.0
申请日：2008-08-22
申请人： Sapporo Medical University , Tokyo University of Science , Kyoto University , Sapporo Immuno Diagnostic Laboratory
发明人： SAHARA, Hiroeki , MORI, Yoko , TAKAHASHI, Nobuaki , SATO, Noriyuki , SUGAWARA, Fumio , SAKAGUCHI, Kengo , MOROHASHI, Kengo , IWABATA, Kazuki , WATASHI, Koichi , SHIMOTOHNO, Kunitada , KIKUCHI, Kokichi , TSUTAE, Wataru , MIYASHITA, Hiroki
CPC分类号： C07K14/47 , G01N33/5767 , Y02A50/53 , Y02A50/60
摘要： Abstract: Disclosed are: a composition and a method for the diagnosis and/or the treatment of a CSABP-related disease, the regulation of the proliferation of an RNA virus and the regulation of an RNA-metabolizing system, which targets a cyclosporine A-binding protein (CSABP); a method for the screening of a component that targets a CSABP; a composition and a method for the detection/inhibition of CsA, NS5B or cyclosphilin B by utilizing a CSABP; a promoter for a CSABP; a method for the screening of a substance capable of regulating the expression of a CSABP by utilizing the promoter; and a method for the determination of the occurrence or clinical stage of a CSABP-related disease.
摘要翻译： 摘要：公开了一种用于诊断和/或治疗CSABP相关疾病的组合物和方法，RNA病毒增殖的调节和RNA代谢系统的调节，其靶向环孢菌素A- 结合蛋白（CSABP）; 用于筛选针对CSABP的组件的方法; 通过利用CSABP检测/抑制CsA，NS5B或环孢菌素B的组合物和方法; CSABP的启动子; 通过利用该启动子筛选能够调节CSABP表达的物质的方法; 以及用于确定CSABP相关疾病的发生或临床阶段的方法。
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