公开(公告)号：EP3231867A1

公开(公告)日：2017-10-18

申请号：EP15867698.1

申请日：2015-12-08

申请人： Sapporo Medical University ,  Sumitomo Dainippon Pharma Co., Ltd.

发明人： SATO, Noriyuki ,  TORIGOE, Toshihiko ,  HIROHASHI, Yoshihiko ,  KANASEKI, Takayuki ,  MIYAMOTO, Sho ,  KOCHIN, Vitaly ,  GOTO, Masashi

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  C07K7/06 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/572 ,  C07K7/06 ,  C07K16/2833 ,  C07K16/30 ,  C07K2317/34 ,  C12N5/0638 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/15 ,  G01N33/50 ,  G01N33/5088 ,  G01N33/574 ,  G01N2333/46

摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by Y o -X o -Z o ; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.

摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 肿瘤干细胞特异性表达的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，所述药物组合物包含上述肿瘤抗原肽作为活性成分; 筛选肿瘤抗原肽的方法; 为实现上述目的，提供了：由Yo-Xo-Zo代表的肽; 由多个连接在一起的表位肽组成的多表位肽，所述多表位肽含有至少一种上述肽作为表位肽之一; 编码上述肽和/或多表位肽的多核苷酸; 包含其作为活性成分的药物组合物; 特征在于诱导CTL的癌症的预防和/或治疗剂; 等等

公开(公告)号：EP3054010B1

公开(公告)日：2020-07-22

申请号：EP14850688.4

申请日：2014-10-03

申请人： Sapporo Medical University

发明人： SATO, Noriyuki ,  TORIGOE, Toshihiko ,  HIROHASHI, Yoshihiko ,  KANASEKI, Takayuki ,  KOCHIN, Vitaly ,  TAKAYA, Akari ,  GOTO, Masashi

IPC分类号： A61K39/00 ,  A61K35/17 ,  C07K7/06 ,  C07K7/08 ,  A61K38/08 ,  A61P35/00

公开(公告)号：EP3054010A1

公开(公告)日：2016-08-10

申请号：EP14850688.4

申请日：2014-10-03

申请人： Dainippon Sumitomo Pharma Co., Ltd. ,  Sapporo Medical University

发明人： SATO, Noriyuki ,  TORIGOE, Toshihiko ,  HIROHASHI, Yoshihiko ,  KANASEKI, Takayuki ,  KOCHIN, Vitaly ,  TAKAYA, Akari ,  GOTO, Masashi

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/28 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting cancer stem cells; a tumor antigen peptide specifically exhibited by cancer stem cells; a pharmaceutical composition for the prevention and/or treatment of cancer, containing same as an effective component thereof; and a method for screening said tumor antigen peptide. A peptide indicated by YO-XO-ZO, a polyepitope peptide including at least one said peptide as an epitope peptide and having a plurality of epitope peptides joined therein, a polynucleotide that codes at least either the peptide or the polyepitope peptide, a pharmaceutical composition containing these as an effective component thereof, and a cancer prevention and/or treatment agent characterized by inducing CTLs.

摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 癌症干细胞特异表现的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，其含有作为其有效成分的药物组合物; 和筛选所述肿瘤抗原肽的方法。 由YO-XO-ZO表示的肽，包含至少一种所述肽作为表位肽并且具有连接在其中的多个表位肽的多表位肽，编码至少肽或多表位肽的多核苷酸，药物组合物 含有这些作为其有效成分的化合物，以及以诱导CTL为特征的癌症预防和/或治疗剂。