INORGANIC POROUS SUBSTRATE, INORGANIC POROUS SUPPORT, AND NUCLEIC ACID PRODUCTION METHOD

    公开(公告)号:EP4151597A1

    公开(公告)日:2023-03-22

    申请号:EP21804320.6

    申请日:2021-05-12

    摘要: An object of the present invention is to provide an efficient nucleic acid production method, in particular, an inorganic porous substrate serving as a precursor of an inorganic porous support with which purity and the like can be further enhanced in the production of a nucleic acid, an inorganic porous support, and a nucleic acid production method using the inorganic porous support. The present invention provides an inorganic porous substrate having a silyl group represented by (i) and (ii) and having characteristics (iii) to (v), an inorganic porous support derived from the inorganic porous substrate, and a nucleic acid production method using the inorganic porous support:
    (i) a silyl group (A): a silyl group represented by the formula (i-1); (ii) a silyl group (B): at least one silyl group selected from the group consisting of silyl groups represented by (ii-1), (ii-2), and (ii-3); (iii) a particle diameter of 1 um or more; (iv) a pore diameter of 20 nm or more; and (v) a cumulative pore volume in a pore diameter range of 40 nm to 1000 nm of more than 0.32 mL/g and 4 mL/g or less.

            (X1)(Y1) a (Z1) b Si-A1-NH-B1 ···     (i-1)

            (P1)(Q1)(R1)Si-J1 ···     (ii - 1)

    POROUS INORGANIC CARRIER AND METHOD FOR PRODUCING NUCLEIC ACID USING SAME

    公开(公告)号:EP3950125A1

    公开(公告)日:2022-02-09

    申请号:EP20783249.4

    申请日:2020-02-28

    摘要: The present invention provides: an inorganic porous carrier that can be used to increase the purity of nucleic acid in a production thereof, and that comprises a linker represented by general formula (1), wherein a mode diameter in a pore distribution as measured by mercury intrusion method is 0.04 µm to 1 µm, and also a predetermined cumulative pore volume ratio is 30 % or less [in the formula (1), a bond marked with * represents a linkage to the oxygen atom of a silanol group in an inorganic porous substance; n is an integer of 1 etc.; R represents independently of each other an alkyl group containing 3 to 10 carbon atoms which may optionally have a substituent such as an alkoxy group etc.; and L represents a single bond; an alkylene group of 1 to 20 carbon atoms; or an alkylene group containing 2 to 20 carbon atoms which contains -CH 2 -Q-CH 2 - group wherein any group Q selected from a group consisting of -O- etc. is inserted into at least one of -CH 2 -CH 2 - group constituting the alkylene group]; and a method for preparing a nucleic acid using the same.

    PEROXIDE-DEGRADING CATALYST
    6.
    发明公开
    PEROXIDE-DEGRADING CATALYST 审中-公开
    过氧化物降解催化剂

    公开(公告)号:EP1908520A1

    公开(公告)日:2008-04-09

    申请号:EP06767294.9

    申请日:2006-06-20

    IPC分类号: B01J31/22 G01N31/10

    摘要: An object of the present invention is to provide a catalyst which decomposes a peroxide effectively and economically under a high temperature while suppressing generation of free radicals, and the present invention provides a peroxide decomposition catalyst containing a base metal atom, wherein a value A indicating a free radical generation amount represented by the (equation 1) is not more than 0.20, and a value B indicating a reaction rate represented by the (equation 2), which can be easily applied to utility such as an agent for preventing deterioration of a polymer electrolyte-type fuel cell and a water electrolysis apparatus, and an antioxidant for medicaments, agrochemicals and foods. A = Mw S / Mw - 1
    (wherein Mw is a weight average molecular weight of poly (sodium 4-styrenesulfonate) after a hydrogen peroxide decomposition test in the test at 80°C in the presence of poly(sodium 4-styrenesulfonate), and Mw(S) is a weight average molecular weight of poly(sodium 4-styrenesulfonate) before the test) B = N PO / N cat
    (wherein N (po) is a mole number of hydrogen peroxide decomposed per 20 minutes in a hydrogen peroxide decomposition test in the (equation 1), and N(cat) is a mole number per metal atom of a catalyst used)

    摘要翻译: 本发明的目的在于提供一种在抑制自由基的产生的同时高效且经济地分解过氧化物的催化剂,本发明提供含有碱金属原子的过氧化物分解催化剂,其中A表示 (式1)表示的自由基产生量为0.20以下,表示由(式2)表示的反应速度的值B可以容易地应用于用途,例如用于防止聚合物劣化的试剂 电解质型燃料电池和水电解装置,以及用于药物,农用化学品和食品的抗氧化剂。 A = MwS / Mw-1(其中Mw是在聚(4-苯乙烯磺酸钠)存在下在80℃的试验中的过氧化氢分解试验后的聚(4-苯乙烯磺酸钠)的重均分子量,和 Mw(S)是试验前的聚(4-苯乙烯磺酸钠)的重均分子量)B = NPO / Ncat(其中N(po)是在过氧化氢分解试验中每20分钟分解的过氧化氢的摩尔数 在(式1)中,N(cat)是所使用的催化剂的每个金属原子的摩尔数)