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16 条记录 (耗时 0.011 秒)

    2-pyranone derivatives and process for production thereof
    1.
    发明公开
    2-pyranone derivatives and process for production thereof 失效
    2-吡咯烷酮衍生物及其生产方法

    公开(公告)号：EP0329361A3

    公开(公告)日：1990-10-31

    申请号：EP89301336.7

    申请日：1989-02-13

    申请人： SUNTORY LIMITED

    发明人： Maeda, Mitsuru ,  Kodama, Tohru ,  Asami, Sumio ,  Amano, Norihide ,  Kusumi, Takaaki ,  Hosono, Hidekazu

    IPC分类号： C07F9/117 ,  C12P17/06

    CPC分类号： A01N57/16 ,  C07F9/6552 ,  C12P17/06 ,  C12R1/585

    摘要： A 2-pyranone derivative represented by the formula (I):
    wherein R represents a hydrogen atom, or a linear, branched alkylcarbonyloxy, or cyclo-alkylcarbonyloxy group having 3 to 10 carbon atoms, and salts thereof; a process for the production of the above-mentioned 2-pyranone derivative (I), comprising the steps of culturing a microorganism belonging to the genus Streptomyces and capable of producing the derivative, to produce the derivative, and recovering the produced derivative from the cultured product; a biocidal composition comprising the above-mentioned 2-pyranone derivative (I); and a microorganism belonging to the genus Streptomyces and capable of producing the above-mentioned 2-pyranone derivatives.

    2-pyranone derivatives and process for production thereof
    2.
    发明授权
    2-pyranone derivatives and process for production thereof 失效
    2-吡喃酮衍生物及其制备方法。

    公开(公告)号：EP0329361B1

    公开(公告)日：1995-12-06

    申请号：EP89301336.7

    申请日：1989-02-13

    申请人： SUNTORY LIMITED

    发明人： Maeda, Mitsuru ,  Kodama, Tohru ,  Asami, Sumio ,  Amano, Norihide ,  Kusumi, Takaaki ,  Hosono, Hidekazu

    IPC分类号： C07F9/117 ,  C12P17/06

    CPC分类号： A01N57/16 ,  C07F9/6552 ,  C12P17/06 ,  C12R1/585

    摘要： A 2-pyranone derivative represented by the formula (I): wherein R represents a hydrogen atom, or a linear, branched alkylcarbonyloxy, or cyclo-alkylcarbonyloxy group having 3 to 10 carbon atoms, and salts thereof; a process for the production of the above-mentioned 2-pyranone derivative (I), comprising the steps of culturing a microorganism belonging to the genus Streptomyces and capable of producing the derivative, to produce the derivative, and recovering the produced derivative from the cultured product; a biocidal composition comprising the above-mentioned 2-pyranone derivative (I); and a microorganism belonging to the genus Streptomyces and capable of producing the above-mentioned 2-pyranone derivatives.

    Enzyme inhibitor and method of producing the same
    3.
    发明公开
    Enzyme inhibitor and method of producing the same 失效
    Enzymhemmer und Methode zu dessen Herstellung。

    公开(公告)号：EP0316907A2

    公开(公告)日：1989-05-24

    申请号：EP88119126.6

    申请日：1988-11-17

    申请人： SUNTORY LIMITED

    发明人： Maeda, Mituru ,  Kodama, Touru ,  Iwasawa, Norio ,  Higuchi, Naoki ,  Amano, Norihide

    IPC分类号： C07K5/00 ,  C12P21/00 ,  A61K37/02

    CPC分类号： C07K5/0205 ,  Y10S435/826

    摘要： Novel peptide analogues which exhibit inhibitory activity against aspartic proteinases of the general formula I:, a novel species of actinomycetous microorganism which produces said novel peptide analogues, a process for producing said novel analogues by culturing said species and a pharmaceutical composition containing said analogues.

    摘要翻译： 表现出对通式I的天冬氨酸蛋白酶具有抑制活性的新型肽类似物：产生所述新肽类似物的放线菌属微生物的新物种，通过培养所述种类生产所述新型类似物的方法和含有所述 类似物。

    Novel superoxide dismutase and process for preparation thereof
    7.
    发明公开
    Novel superoxide dismutase and process for preparation thereof 失效
    Superoxiddismutase和Verfahren zu deren Herstellung。

    公开(公告)号：EP0218480A2

    公开(公告)日：1987-04-15

    申请号：EP86307659.2

    申请日：1986-10-03

    申请人： SUNTORY LIMITED

    发明人： Asami, Sumio ,  Amano, Norihide ,  Amachi, Teruo ,  Yoshizumi, Hajime

    IPC分类号： C12N9/02

    CPC分类号： C12N9/0089 ,  Y10S435/822

    摘要： A novel superoxide dismutase having the following properties: (a) action: the superoxide dismutase disproportionates two superoxide radicals to a hydrogen peroxide and a molecular oxygen; (b) substrate specificity: the superoxide dismutase acts on a superoxide radical: (c) optimum pH: the optimum a pH is about 8; (d) stable pH: the superoxide dismutase is stable at pH of 4.5 to 8.0 (when the superoxide dismutase is treated at 25°C for 60 minutes, the residual activity is at least 80%); (e) thermal stability: when the residual activity is measured after the heat treatment for 10 minutes at a pH of 7.8, the superoxide dismutase is stable at treatment temperatures of up to about 50°C, and the residual activity is 90% at a treatment temperature of 60°C, and 50% at a treatment temperature of 70°C; (f) molecular weight: the molecular weight is about 8.8 x 10⁴, as determined according to the gel filtration method; (g) absorption spectrum of ultraviolet and visible region: the maximum absorbance appears at about 280 nm, the minimum absorbance appears at about 250 nm and a shoulder appears at about 290 nm; (h) molecular extinction coefficient: the molecular extinction coefficient at 280 nm is about 1.45 x 10⁵ M⁻¹cm⁻¹; (i) inhibition: the activity is not inhibited by an addition of 1 mM potassium cyanide and exponential inactivation is caused with the lapse of time by an addition of 5 mM hydrogen peroxide; and (j) metal analysis: the superoxide dismutase contains 1.56 g-atoms of iron per mole of oxygen but does not contain copper and manganese; and a process for the preparation of the above-mentioned superoxide dismutase which comprises culturing a superoxide dismutase-producing strain belonging to the genus Norcardopsis in a culture medium to form and accumulate a superoxide dismutase in the culture medium, and recovering the superoxide dismutase from the cultured product.

    摘要翻译： 一种由Nocardiopsis属超氧化物歧化酶生产菌株制备的新型超氧化物歧化酶。 该酶是分子量约为8.8×10 4的四聚物，由约2.2×10 4的亚单位组成。 超氧化物歧化酶每摩尔含有1.56克原子铁，但不含铜或锰。 浓度为1mM的氰化钾不抑制活性，但是由5mM过氧化氢引起指数失活。

    2-pyranone derivatives and process for production thereof
    9.
    发明公开
    2-pyranone derivatives and process for production thereof 失效
    2-Pyranon-Derivat und Verfahren zu dessen Herstellung。

    公开(公告)号：EP0329361A2

    公开(公告)日：1989-08-23

    申请号：EP89301336.7

    申请日：1989-02-13

    申请人： SUNTORY LIMITED

    发明人： Maeda, Mitsuru ,  Kodama, Tohru ,  Asami, Sumio ,  Amano, Norihide ,  Kusumi, Takaaki ,  Hosono, Hidekazu

    IPC分类号： C07F9/117 ,  C12P17/06

    CPC分类号： A01N57/16 ,  C07F9/6552 ,  C12P17/06 ,  C12R1/585

    摘要： A 2-pyranone derivative represented by the formula (I):

    wherein R represents a hydrogen atom, or a linear, branched alkylcarbonyloxy, or cyclo-alkylcarbonyloxy group having 3 to 10 carbon atoms, and salts thereof; a process for the production of the above-mentioned 2-pyranone derivative (I), comprising the steps of culturing a microorganism belonging to the genus Streptomyces and capable of producing the derivative, to produce the derivative, and recovering the produced derivative from the cultured product; a biocidal composition comprising the above-mentioned 2-pyranone derivative (I); and a microorganism belonging to the genus Streptomyces and capable of producing the above-mentioned 2-pyranone derivatives.

    摘要翻译： 由式（I）表示的2-吡喃酮衍生物：其中R表示氢原子，或直链，支链烷基羰基氧基或碳原子数3〜10的环烷基羰基氧基及其盐; 一种制备上述2-吡喃酮衍生物（I）的方法，包括以下步骤：培养属于链霉菌属的微生物并能够制备该衍生物，以产生该衍生物，并从所培养的培养物中回收所产生的衍生物 产品; 包含上述2-吡喃酮衍生物（I）的杀生物组合物; 和属于链霉菌属的微生物，能够生产上述2-吡喃酮衍生物。

    Novel superoxide dismutase and process for preparation thereof
    10.
    发明公开
    Novel superoxide dismutase and process for preparation thereof 失效
    新型超氧化物歧化酶及其制备方法

    公开(公告)号：EP0218480A3

    公开(公告)日：1988-04-20

    申请号：EP86307659

    申请日：1986-10-03

    申请人： Suntory Limited

    发明人： Asami, Sumio ,  Amano, Norihide ,  Amachi, Teruo ,  Yoshizumi, Hajime

    IPC分类号： C12N09/02

    CPC分类号： C12N9/0089 ,  Y10S435/822

    摘要： A novel superoxide dismutase having the following properties: (a) action: the superoxide dismutase disproportionates two superoxide radicals to a hydrogen peroxide and a molecular oxygen; (b) substrate specificity: the superoxide dismutase acts on a superoxide radical: (c) optimum pH: the optimum a pH is about 8; (d) stable pH: the superoxide dismutase is stable at pH of 4.5 to 8.0 (when the superoxide dismutase is treated at 25°C for 60 minutes, the residual activity is at least 80%); (e) thermal stability: when the residual activity is measured after the heat treatment for 10 minutes at a pH of 7.8, the superoxide dismutase is stable at treatment temperatures of up to about 50°C, and the residual activity is 90% at a treatment temperature of 60°C, and 50% at a treatment temperature of 70°C; (f) molecular weight: the molecular weight is about 8.8 x 10⁴, as determined according to the gel filtration method; (g) absorption spectrum of ultraviolet and visible region: the maximum absorbance appears at about 280 nm, the minimum absorbance appears at about 250 nm and a shoulder appears at about 290 nm; (h) molecular extinction coefficient: the molecular extinction coefficient at 280 nm is about 1.45 x 10⁵ M⁻¹cm⁻¹; (i) inhibition: the activity is not inhibited by an addition of 1 mM potassium cyanide and exponential inactivation is caused with the lapse of time by an addition of 5 mM hydrogen peroxide; and (j) metal analysis: the superoxide dismutase contains 1.56 g-atoms of iron per mole of oxygen but does not contain copper and manganese; and a process for the preparation of the above-mentioned superoxide dismutase which comprises culturing a superoxide dismutase-producing strain belonging to the genus Norcardopsis in a culture medium to form and accumulate a superoxide dismutase in the culture medium, and recovering the superoxide dismutase from the cultured product.

    摘要翻译： 一种由Nocardiopsis属超氧化物歧化酶生产菌株制备的新型超氧化物歧化酶。 该酶是分子量约为8.8×10 4的四聚物，由约2.2×10 4的亚单位组成。 超氧化物歧化酶每摩尔含有1.56克原子铁，但不含铜或锰。 浓度为1mM的氰化钾不抑制活性，但是由5mM过氧化氢引起指数失活。