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6 条记录 (耗时 0.009 秒)

    PROSTAGLANDIN DERIVATIVES
    2.
    发明公开
    PROSTAGLANDIN DERIVATIVES 审中-公开
    PROSTAGLANDIN DERIVATE

    公开(公告)号：EP1219601A4

    公开(公告)日：2004-10-27

    申请号：EP00957063

    申请日：2000-09-08

    申请人： TAISHO PHARMA CO LTD ,  SATO FUMIE

    发明人： SATO FUMIE ,  TANAMI TOHRU ,  TANAKA HIDEO ,  ONO NAOYA ,  YAGI MAKOTO ,  HIRANO HITOMI

    IPC分类号： A61P9/08 ,  A61P43/00 ,  C07C405/00 ,  A61K31/5575 ,  C07D295/22

    CPC分类号： C07C405/00

    摘要： Novel prostaglandin derivatives represented by general formula (I), pharmaceutically acceptable salts thereof, or hydrates of both, wherein X is CH2, O, S, or the like; Y is ethylene, vinylene, ethynylene, or the like; Z is ethylene, vinylene, or ethynylene; R is hydrogen, alkyl, or cycloalkyl; R is alkyl, alkenyl, alkynyl, cycloalkyl, or the like; and R is hydrogen, alkyl, or the like. The prostaglandin derivatives exhibit an excellent inhibitory activity against the proliferation of vascular smooth muscle and are useful as preventive or therapeutic drugs for post-PTCA restenosis and so on.

    PROSTAGLANDIN DERIVATIVES
    5.
    发明公开
    PROSTAGLANDIN DERIVATIVES 有权
    前列腺素衍生物

    公开(公告)号：EP1211242A4

    公开(公告)日：2004-11-03

    申请号：EP00957064

    申请日：2000-09-08

    申请人： TAISHO PHARMA CO LTD

    发明人： SATO FUMIE ,  TANAMI TOHRU ,  TANAKA HIDEO ,  ONO NAOYA ,  YAGI MAKOTO ,  HIRANO HITOMI

    IPC分类号： A61P9/10 ,  A61P25/20 ,  A61P27/06 ,  A61P43/00 ,  C07C405/00 ,  A61K31/5575

    CPC分类号： C07C405/00 ,  C07C405/0016

    摘要： Prostaglandin derivatives of general formula (I), pharmaceutically acceptable salts thereof, or hydrates of both: [wherein X is alpha a- or beta -substituent halogeno; Y is ethylene, vinylene, or ethynylene; A is O(CH2)n, S(O)p(CH2)n, O(CH2)qO(CH2)r, O(CH2)qS(O)p(CH2)r, S(O)p(CH2)qS(O)p(CH2)r, or S(O)p(CH2)qO(CH2)r (wherein n is an integer of 1 to 5; p is 0, 1 or 2; q is an integer of 1 to 3; and r is 0 or 1); R is C3-10 cycloalkyl, C1-4 alkyl C3-10 cycloalkyl, C3-10 cycloalkyl C1-4 alkyl, C5-10 alkyl, C5-10 alkenyl, C5-10 alkynyl, or a bridged cyclic hydrocarbon group; R is H, C1-10 alkyl, or C3-10 cycloalkyl; and m is 0, 1 or 2]. These compounds are novel and exhibit excellent prostaglandin D2-like agonism and a sleep-inducing effect.

    摘要翻译： 通式（I）的前列腺素衍生物，其药学上可接受的盐或两者的水合物：[其中X是α-或β-取代基卤代; Y是亚乙基，亚乙烯基或亚乙炔基; （O）p（CH 2）n，O（CH 2）q O（CH 2）r，O（CH 2）q S（O）p qS（O）p（CH 2）r或S（O）p（CH 2）q O（CH 2）r（其中n是1至5的整数; p是0,1或2; q是1至 3;并且r是0或1）; R 1为C 3-10环烷基，C 1-4烷基C 3-10环烷基，C 3-10环烷基C 1-4烷基，C 5-10烷基，C 5-10烯基，C 5-10炔基或桥环烃基; R 2是H，C 1-10烷基或C 3-10环烷基; 并且m是0,1或2]。 这些化合物是新颖的并且表现出优异的前列腺素D 2样激动作用和睡眠诱导作用。

    PROSTAGLANDIN E1 DERIVATIVES
    6.
    发明公开
    PROSTAGLANDIN E1 DERIVATIVES 审中-公开
    PROSTAGLANDIN E1 DERIVATE

    公开(公告)号：EP1170286A4

    公开(公告)日：2003-05-28

    申请号：EP00915427

    申请日：2000-04-07

    申请人： TAISHO PHARMA CO LTD ,  SATO FUMIE

    发明人： SATO FUMIE ,  TANAMI TOHRU ,  TANAKA HIDEO ,  ONO NAOYA ,  YAGI MAKOTO ,  HIRANO HITOMI

    IPC分类号： A61K31/5575 ,  A61P9/00 ,  C07C405/00

    CPC分类号： C07C405/00 ,  A61K31/5575 ,  C07C405/0033

    摘要： Prostaglandin E1 derivatives represented by general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same wherein A represents ethylene, vinylene, ethynylene, O(CH2)q or S(O)r(CH2)q; R represents C3-10 cycloalkyl, (C1-4 alkyl)(C3-10 cycloalkyl), (C3-10 cycloalkyl)(C1-4 alkyl), C1-10 alkyl optionally substituted by hydroxy or C1-4 alkoxy, C2-10 alkenyl, optionally substituted by hydroxy or C1-4 alkoxy, C2-10 alkynyl, optionally substituted by hydroxy or C1-4 alkoxy, or crosslinked hydrocarbyl; R represents a hydrogen atom, C1-10 alkyl or C3-10 cycloalkyl; m is an integer of from 1 to 5; n is an integer of from 1 to 4; p is 0, 1 or 2; q is an integer of from 1 to 5; and r is 0, 1 or 2. These compounds are novel PG derivatives having an excellent inhibitory effect on vascular smooth muscle proliferation and being useful as preventives for post-PTCA reconstriction.