公开(公告)号：EP2404997A4

公开(公告)日：2013-06-26

申请号：EP10748842

申请日：2010-03-05

申请人： UNIV MIE ,  TAKARA BIO INC

发明人： SHIKU HIROSHI ,  IKEDA HIROAKI ,  IWAMURA KOICHI ,  MINENO JUNICHI ,  KATO IKUNOSHIN

IPC分类号： C12N15/00 ,  A61K31/713 ,  A61K35/12 ,  A61K35/14 ,  A61K48/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  C12N5/0783 ,  C12N5/10 ,  C12N15/09 ,  C12N15/113

CPC分类号： A61K35/17 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N15/113 ,  C12N2310/14 ,  C12N2501/48 ,  C12N2501/599 ,  C12N2310/531

摘要： Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases.

摘要翻译： 公开了一种增强T细胞功能的方法，其特征在于抑制T细胞中程序性死亡-1配体1（PD-L1）和/或程序性死亡-1配体2（PD-L2）的表达 。 还公开了通过功能增强方法产生的功能增强T细胞。 还公开了包含功能增强T细胞的治疗剂。 T细胞可以增强对癌症的免疫应答，并且可用于对癌症有效的免疫治疗和治疗或预防感染性疾病和自身免疫性疾病。

公开(公告)号：EP2172547A4

公开(公告)日：2011-01-05

申请号：EP08777135

申请日：2008-06-10

申请人： TAKARA BIO INC ,  UNIV MIE

发明人： MINENO JUNICHI ,  OKAMOTO SACHIKO ,  SUMIOKA RISA ,  KITAGAWA MASANARI ,  SHIKU HIROSHI ,  KATO IKUNOSHIN

IPC分类号： C12N15/09 ,  C12N5/10

CPC分类号： C07K14/7051 ,  C12N15/85 ,  C12N2800/40 ,  C12N2840/102

公开(公告)号：EP3031916B1

公开(公告)日：2017-06-07

申请号：EP15196028

申请日：2008-06-10

申请人： TAKARA BIO INC ,  UNIV MIE

发明人： MINENO JUNICHI ,  OKAMOTO SACHIKO ,  SUMIOKA RISA ,  KITAGAWA MASANARI ,  SHIKU HIROSHI ,  KATO IKUNOSHIN

IPC分类号： C12N15/09 ,  C07K14/725 ,  C12N5/10 ,  C12N15/85

CPC分类号： C07K14/7051 ,  C12N15/85 ,  C12N2800/40 ,  C12N2840/102

公开(公告)号：EP1892294A4

公开(公告)日：2010-04-14

申请号：EP06757239

申请日：2006-06-12

申请人： TAKARA BIO INC

发明人： MARUI TAKAHIRO ,  ENOKI TATSUJI ,  SAGAWA HIROAKI ,  KATO IKUNOSHIN

IPC分类号： C12N15/09 ,  C12N5/10

CPC分类号： C12N15/86 ,  C07K14/78 ,  C12N2533/52 ,  C12N2740/13045 ,  C12N2810/857

公开(公告)号：EP1754473A4

公开(公告)日：2010-03-03

申请号：EP05743726

申请日：2005-05-30

申请人： TAKARA BIO INC

发明人： KAWAI TAKASHI ,  MIZUTANI SHIGETOSHI ,  ENOKI TATSUJI ,  SAGAWA HIROAKI ,  SAKAI TAKESHI ,  SHIMANAKA KAZUO ,  KATO IKUNOSHIN

IPC分类号： A61K31/047 ,  A23L1/30 ,  A61K36/07 ,  A61P35/00

CPC分类号： A61K36/07 ,  A23L33/105 ,  A61K31/047

摘要： According to the present invention, an antitumor agent, an apoptosis-inducing agent or an angiogenesis-suppressing agent having the effect even via an oral route, containing a compound contained in an inexpensive edible basidiomycete or a composition derived from an edible basidiomycete, and a food having the antitumor activity, the apoptosis-inducing activity or the angiogenesis-suppressing activity containing the compound or the composition can be obtained. Therefore, the present invention is particularly useful, especially in the field of a medicine and a health food.

公开(公告)号：EP1707211A4

公开(公告)日：2009-08-05

申请号：EP04819454

申请日：2004-11-26

申请人： TAKARA BIO INC

发明人： SANO MUTSUMI ,  IZU HIROYUKI ,  IMAMURA MITSUO ,  OKAMOTO MOTOKO ,  KURITA TOYOHISA ,  KATO IKUNOSHIN

IPC分类号： A61K36/18 ,  A23L1/30 ,  A61K8/18 ,  A61K8/97 ,  A61K8/99 ,  A61K31/201 ,  A61K36/00 ,  A61K36/02 ,  A61K36/03 ,  A61K36/16 ,  A61K36/28 ,  A61K36/282 ,  A61K36/42 ,  A61K36/61 ,  A61K36/75 ,  A61P17/04 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  A61Q19/02 ,  C07C59/42

CPC分类号： A61K31/201 ,  A23L33/105 ,  A61K8/97 ,  A61K36/03 ,  A61K36/16 ,  A61K36/28 ,  A61K36/282 ,  A61K36/42 ,  A61K36/61 ,  A61K36/75 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/42

摘要： It is intended to provide a ceramidase inhibitor which inhibits ceramidase activity, in particular, neutral/alkaline ceramidase activity, characterized by containing, as the active ingredient, a substance obtained by treating at least one plant selected from the group consisting of plants belonging to the families Ginkgo, Curcurbitaceae, Rutaceae, Laminaria, Myrtaceae and Asteraceae; and drugs, quasi drugs, cosmetics and foods containing the above inhibitor.

公开(公告)号：EP1847596A4

公开(公告)日：2009-02-25

申请号：EP06713114

申请日：2006-02-06

申请人： TAKARA BIO INC

发明人： CHONO HIDETO ,  KATAYAMA YASUSHI ,  OKUYAMA HIROMI ,  MINENO JUNICHI ,  ASADA KIYOZO ,  KATO IKUNOSHIN

IPC分类号： C12N7/00 ,  C12N15/09

CPC分类号： C12N11/02 ,  C12N7/00 ,  C12N2740/10051

摘要： A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding activity is sealed in a container holding a solid phase having the substance with retrovirus binding activity immobilized thereon.

公开(公告)号：EP1748071A4

公开(公告)日：2009-01-07

申请号：EP05741599

申请日：2005-05-19

申请人： TAKARA BIO INC

发明人： SHODAI TOSHIHIRO ,  KOBORI HIROSHI ,  SAGARA TAKEHIRO ,  ENDO HIROSHI ,  TAKAKURA HIKARU ,  TOMONO JUN ,  SAGAWA HIROAKI ,  MUKAI HIROYUKI ,  KATO IKUNOSHIN

IPC分类号： C12N15/09 ,  C12N9/12 ,  C12N9/22 ,  C12N15/70 ,  C12P21/02

CPC分类号： C12N15/70 ,  C12N9/1276 ,  C12N9/22 ,  C12P21/02

摘要： A process for producing a target protein at low temperature, comprising inducing expression of not only a vector having introduced therein a gene coding for the target protein but also a vector having a chaperone gene introduced therein.

公开(公告)号：EP1627632A4

公开(公告)日：2009-01-07

申请号：EP04733687

申请日：2004-05-18

申请人： TAKARA BIO INC

发明人： ENOKI TATSUJI ,  KOBAYASHI EIJI ,  OGAWA KINUKO ,  KUDO YOKO ,  TANABE MASASHIGE ,  OHNOGI HIROMU ,  SAGAWA HIROAKI ,  KATO IKUNOSHIN

IPC分类号： A61K31/11 ,  A23K1/16 ,  A23L1/30 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/11 ,  A23K20/00 ,  A23L33/10

摘要： A preventive or therapeutic agent for diseases accompanied by alteration of insulin level or insulin response, insulin-like functioning agent, food, beverage or feed, promoter for glucose intake into cells, or inducer of differentiation into fat cells, characterized in that at least one compound selected from the group consisting of a specified compound exhibiting insulin-like activity, its derivatives and pharmacologically acceptable salts thereof is contained as an active ingredient.

摘要翻译： 一种伴随胰岛素水平或胰岛素反应改变的疾病，胰岛素样功能试剂，食物，饮料或饲料，葡萄糖摄入细胞的促进剂或分化为脂肪细胞的诱导剂的预防或治疗剂，其特征在于，至少一种 含有选自具有胰岛素样活性的特定化合物，其衍生物及其药理学上可接受的盐作为有效成分的化合物。

公开(公告)号：EP1795601A4

公开(公告)日：2008-02-13

申请号：EP05787945

申请日：2005-09-28

申请人： TAKARA BIO INC

发明人： CHONO HIDETO ,  OKUYAMA HIROMI ,  EGASHIRA TOMOE ,  KOYAMA NOBUTO ,  MINENO JUNICHI ,  KATO IKUNOSHIN

IPC分类号： C12N15/867 ,  C12N5/10 ,  C12N7/00

CPC分类号： C12N9/1051 ,  C12N15/86 ,  C12N2740/13043 ,  C12N2740/13052 ,  C12N2799/02 ,  C12N2810/10

摘要： The N-acetylglucosaminyltransferase III activity is enhanced in a cell carrying retrovirus-origin gag-pol gene and env gene. By constructing a retrovirus vector with the use of the above cell, a retrovirus vector having a modified sugar chain structure can be obtained. The retrovirus vector constructed by this method shows a high infection efficiency particularly in the presence of a functional substance.