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公开(公告)号：EP2144892A2
公开(公告)日：2010-01-20
申请号：EP08727241.5
申请日：2008-03-31
IPC分类号： C07D281/16 , C07D417/04 , C07D417/14
CPC分类号： C07D281/16 , C07D417/04 , C07D417/14 , Y10T436/141111
摘要： Provided is an improved synthesis of quetiapine and pharmaceutically acceptable salts using a compound of formula [III] wherein A is chlorine, bromine or iodine which is formed by reaction of a compound of formula [II] with a halogenating agent and an aliphatic halogenated hydrocarbon in the absence of a base.
摘要翻译： 提供了使用式[III]化合物改进喹硫平及其药学上可接受的盐的合成，其中A是通过式[II]化合物与卤化剂和脂肪族卤代烃反应形成的氯，溴或碘 没有基地。
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2.发明公开
公开(公告)号：EP2032586A2
公开(公告)日：2009-03-11
申请号：EP08743067.4
申请日：2008-04-18
发明人： KANSAL, Vinod, Kumar , CHAURASIA, Brijnath, P. , PATEL, Hitesh, K. , GOTHALIA, Vrajlal , GANDHI, Hiren
CPC分类号： C07F9/5352 , C07F7/1856 , C07F9/4006
摘要： The present invention relates to intermediates of rosuvastatin and processes for the production thereof.
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公开(公告)号：EP1943256A2
公开(公告)日：2008-07-16
申请号：EP06827341.6
申请日：2006-10-31
发明人： KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , PANDEY, Saurabh , PATEL, Rakesh , WIZEL, Shlomit , HILDESHEIM, Jean
IPC分类号： C07D501/00 , A61K31/41 , A61P31/12
CPC分类号： C07D501/22 , C07D501/00
摘要： The present invention encompasses the solid state chemistry of cefdinir potassium salt.
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4.发明公开PROCESSES FOR THE PURIFICATION OF (3R,4S)-4-(4-HYDROXY-PROTECTED-PHENYL)-1-(4-FLUOROPHENYL)-3-(4-FLUOROPHENYL)-3-OXOPROPYL¨AZETIDIN-2-ONE 审中-公开PROCEDURE FOR CLEANING（3R，4S）-4-（4-羟基保护的 - 苯基）-1-（4-氟苯基）-3-（4-氟苯基）-3-氧代 - 丙基 - 氮杂环丁烷-2-酮
公开(公告)号：EP1937636A1
公开(公告)日：2008-07-02
申请号：EP07755415.2
申请日：2007-04-10
IPC分类号： C07D205/08 , C07D405/06 , A61K31/397 , A61P3/06
CPC分类号： C07D205/08 , C07D405/06 , Y02P20/55
摘要： Provided are processes for purifying (3R,4S)-4-(4-hydroxyprotected-phenyl)- l-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one having the following formula II, wherein X and Y are hydrogen or a substituted or unsubstituted C1-8 alkyl; n is an integer between 0 and 3; and P is a hydroxyl protecting group. The Compound of formula II may be converted to an azetidinone compound, which is useful, for example, in reducing cholesterol in mammals.
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公开(公告)号：EP2069320A2
公开(公告)日：2009-06-17
申请号：EP08770003.5
申请日：2008-06-02
发明人： KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , VASOYA, Sanjay, L. , RAFILOVICH, Michal , BEN MOHA-LERMAN, Elena , LIFSHITZ-LIRON, Revital
IPC分类号： C07D307/77 , A61K31/343 , A61P43/00
CPC分类号： C07D307/93 , C07D307/79
摘要： The present invention provides processes and intermediates for the synthesis of ramelteon.
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6.发明公开
公开(公告)号：EP2021318A2
公开(公告)日：2009-02-11
申请号：EP08742247.3
申请日：2008-03-24
发明人： KANSAL, Vinod, Kumar , CHAURASIA, Brijnath, P. , SHELKE, Shivaji, Haribhau , TIWARI, Anad, Prakash
IPC分类号： C07C247/12
CPC分类号： C07C1/26 , C07C17/10 , C07C2529/40 , C07C9/00 , C07C19/075
摘要： Provided are syntheses of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)- Pregabalin via a chiral intermediate of the following formula (4) wherein Ar is a C6-10 aromatic group, R is a straight or branched C1-4 alkyl, ester, or carboxylic acid, and R1 is a straight or branched C1-5 alkyl, aralkyl, or substituted aralkyl.
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公开(公告)号：EP1931648A2
公开(公告)日：2008-06-18
申请号：EP07837444.4
申请日：2007-08-28
发明人： KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , VASOYA, Sanjay, L. , LUNAGARIYA, Vijaykumar, D.
IPC分类号： C07D257/04 , C07D403/10
CPC分类号： C07D257/04 , C07D403/10
摘要： Provided are processes for the synthesis of 5 -phenyl- 1-trityl-lH-tetrazole, an intermediate useful in the synthesis of irbesartan. The tritylation of 5-phenyl-lH-tetrazole is carried out using phase transfer catalysis in a biphasic solvent system.
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公开(公告)号：EP1848724A2
公开(公告)日：2007-10-31
申请号：EP06827338.2
申请日：2006-10-31
发明人： KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , PANDEY, Saurabh , PATEL, Rakesh , WIZEL, Shlomit
IPC分类号： C07D513/04
CPC分类号： C07D501/00
摘要： The invention relates to processes for preparing cefdinir via its potassium and cesium salts.
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9.发明公开CHIRAL 3-CARBAMOYLMETHYL-5-METHYL HEXANOIC ACIDS, KEY INTERMEDIATES FOR THE NEW SYNTHESIS OF (S)-PREGABALIN 审中-公开手性3-氨基甲酰基甲基-5-甲基 - 己作为（S） - 普瑞巴林的重构重要中间体
公开(公告)号：EP1802568A1
公开(公告)日：2007-07-04
申请号：EP06814991.3
申请日：2006-09-19
IPC分类号： C07C233/05 , C07C227/32 , C07C231/18 , C07C229/08
CPC分类号： C07C227/32 , C07B2200/07 , C07C231/18 , C07C233/05 , C07C237/22 , C07C229/08
摘要： The invention encompasses the synthesis of (S)-(+)-3-(aminomethyl)-5- methylhexanoic acid, (S)-Pregabalin, via the intermediate, (3R)-5-methyl-3-(2-oxo-2{[(lR)- l-phenylethyl]amino} ethyl)hexanoic acid.
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10.发明公开VARENICLINE TOSYLATE, AN INTERMEDIATE IN THE PREPARATION PROCESS OF VARENICLINE L-TARTRATE 审中-公开瓦伦尼克林甲苯磺酸盐，中间作者瓦伦尼克林生产L-酒石酸
公开(公告)号：EP2268639A2
公开(公告)日：2011-01-05
申请号：EP09751575.3
申请日：2009-05-21
发明人： AHMAD, Suhail , KANSAL, Vinod, Kumar , PIRAN, Maytal , HAREL, Zvi
IPC分类号： C07D471/08 , A61P25/34 , A61K31/4995
CPC分类号： C07D471/08
摘要： Crystalline forms of Varenicline Tosylate, processes for preparing those crystalline forms of Varenicline Tosylate, and processes for obtaining high purity Varenicline base using Varenicline Tosylate are provided.
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