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公开(公告)号：EP3135315A1
公开(公告)日：2017-03-01
申请号：EP15783466.4
申请日：2015-04-20
Inventor： OKAMURA, Yosuke , NAGASE, Yu , KOMACHI, Takuya , HOCHI, Motonori , SEKIDO, Yuki , ARAKANE, Toru
CPC classification number: A61L31/00 , A61L15/16 , A61L15/24 , A61L15/26 , A61L15/28 , A61L15/64 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/148 , A61L2400/12 , B32B7/045 , B32B9/02 , B32B9/04 , B32B9/045 , B32B27/08 , B32B27/306 , B32B27/36 , B32B2250/05 , B32B2250/24 , B32B2250/44 , B32B2307/7163 , B32B2307/73 , B32B2535/00 , C08L67/04 , C08L5/04 , C08L29/04
Abstract: The present invention provides a polymer laminate in which 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. By the present invention, a polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.
Abstract translation: 本发明提供一种聚合物层叠体，其中层叠2〜100层各自含有生物降解性树脂，厚度为10nm〜400nm的聚合物层叠体，至少一层最外层的厚度为10nm〜180nm， 最外层彼此连接。 通过本发明，可以获得生物相容性和机械强度优异且适用于医疗用途如伤口敷料和防粘附材料的聚合物层压体。
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公开(公告)号：EP3231457A1
公开(公告)日：2017-10-18
申请号：EP15867856.5
申请日：2015-12-04
Applicant: Toray Industries, Inc. , Nanotheta Co, Ltd.
Inventor： HOCHI, Motonori , SEKIDO, Yuki , SAITO, Akihiro , TAKEOKA, Shinji , OHTSUBO, Shinya , HINOKI, Akinari , KINOSHITA, Manabu
CPC classification number: A61L15/28 , A61L15/24 , A61L15/26 , A61L31/042 , A61L31/048 , A61L31/06 , B32B27/00 , B32B27/32 , C08L5/08 , C08L67/04
Abstract: The purpose of the present invention is to provide a laminated film that is highly biocompatible and easy to handle, has good pasting ability and contact to an organ tissue and rarely induces infections. The laminated film provided by the present invention, which comprises a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle, and, when stuck to an adherend with curved surface, the laminated film shows excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. Moreover, the acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs, etc. Thus, the laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.
Abstract translation: 本发明的目的是提供一种生物相容性高，操作容易，粘贴性良好，与器官组织接触，极少引起感染的层压薄膜。 由聚乳酸系树脂层和层压在聚乳酸系树脂层侧的一个或多个乙酰化透明质酸层构成的本发明提供的层压膜柔韧性高，易于处理， 粘附到具有曲面的被粘物上时，由于乙酰化透明质酸层可以容易地用聚乳酸系树脂层中的水溶液除去，因此对被粘物显示优异的追随性，粘附性和涂布性， 薄膜形状。 此外，乙酰化透明质酸和聚乳酸类树脂是可生物降解的，因此，该层压膜与皮肤和器官如内脏器官等高度相容。因此，该层压膜最佳地可用作外用皮肤材料 应用如伤口涂层材料，粘合抑制剂和皮肤护理制品。
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Patent Agency Ranking
公开(公告)号：EP2974862B1
公开(公告)日：2020-05-27
申请号：EP14762989.3
申请日：2014-03-06
Applicant: Toray Industries, Inc. , Nanotheta Co, Ltd.
Inventor： HOCHI, Motonori , GOTO, Yuki , MINOMO, Katsuhiro , TAMIMIYA, Naomi
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公开(公告)号：EP3295966A1
公开(公告)日：2018-03-21
申请号：EP16792702.9
申请日：2016-05-11
Applicant: Toray Industries, Inc. , Nanotheta Co, Ltd.
Inventor： HOCHI, Motonori , SEKIDO, Yuki , ITAGAKI, Ichiro , ARAKANE, Toru , OHTSUBO, Shinya , TAKEOKA, Shinji , MURATA, Atsushi , FUJII, Mao , ISHIZUKA, Yuya , SHOJI, Shuichi , MIZUNO, Jun , KASAHARA, Takashi
CPC classification number: C08J5/18 , A61K8/04 , A61K8/8117 , A61K8/8152 , A61K8/8176 , A61K8/85 , A61K8/86 , A61L15/22 , A61L15/225 , A61L15/24 , A61L15/26 , A61L31/00 , A61L31/041 , A61L31/048 , A61L31/06 , A61Q19/00 , C08J2325/06 , C08J2333/12 , C08J2367/04 , C08J2467/04 , C08L25/06 , C08L33/12 , C08L67/04
Abstract: Provided are: a polymer film characterized in that the average film thickness T 0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm ≤ T 0 ≤ 1000 nm, (b) 0.1 µm ≤ L ≤ 500 µm, (c) 0.01 GPa ≤ E ≤ 4.3 GPa, (d) Δ = 1 - T 1 /T 2 , (e) 0.346E x 10 -9 - 1.499 -9 + 0.316. According to the present invention, a polymer film which is easy to handle and has excellent followability, coatability, adhesiveness, and adherence with respect to organ tissues; and a dispersion liquid and an agglomerate using the same can be provided.
Abstract translation: 本发明提供一种聚合物膜，其特征在于，沿着通过二维投影的重心的直线D使得聚合物膜的面积最大化的平均膜厚度T0满足方程（a），平均值 从重心到边缘的距离1的值满足方程（b），杨氏模量E满足方程（c），并且由方程（d）定义的厚度偏差Δ满足方程（e）; 以及使用其的分散液和团块。 （a）10nm≤T0≤1000nm，（b）0.1μm≤L≤500μm，（c）0.01GPa≤E≤4.3GPa，（d）Δ= 1 -T 1 / T 2，（e）0.346E x 10-9-1.499 <Δ<-0.073E×10-9 + 0.316。 根据本发明，提供一种易于处理且具有优异的追随性，涂布性，粘附性和对器官组织的粘附性的聚合物膜; 并且可以提供分散液和使用其的分散液。
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公开(公告)号：EP1191054A1
公开(公告)日：2002-03-27
申请号：EP01917864.9
申请日：2001-04-10
Applicant: TORAY INDUSTRIES, INC.
Inventor： HOCHI, Motonori , TANAKA, Shigeru , HIROTA, Kusato
CPC classification number: C09D7/61 , C08K3/346 , Y10T428/1341 , Y10T428/1359 , Y10T428/1379 , Y10T428/1383 , Y10T428/252 , Y10T428/259 , Y10T428/31667 , Y10T428/31699 , Y10T428/31928
Abstract: A laminated film is provided which is constituted essentially of a resin substrate and a coated film disposed thereon. The coated film comprises a montmorillonite containing a cation exchanger other than sodium ions and a water-soluble polymer. The laminated film offers a high oxygen-permeability barrier at high humidity and firm bonding between the coated film and the resin substrate at high humidity. A packaging material derived from the laminated film is also provided.
Abstract translation: 提供一种基本上由树脂基材和设置在其上的涂膜构成的层压膜。 该涂膜包含含有除钠离子以外的阳离子交换剂和水溶性聚合物的蒙脱土。 该层压膜在高湿度下提供高氧渗透性屏障并且在高湿度下在涂膜和树脂基底之间牢固结合。 还提供了由层压膜得到的包装材料。
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公开(公告)号：EP3520825A1
公开(公告)日：2019-08-07
申请号：EP17856413.4
申请日：2017-09-29
Applicant: Toray Industries, Inc. , Nanotheta Co., Ltd.
Inventor： SAITO, Akihiro , NAKANISHI, Megumi , TANAHASHI, Kazuhiro , ARAKANE, Toru , HOCHI, Motonori , SUZUKI, Ai , OKABAYASHI, Koji , TAKEOKA, Shinji , FUJIE, Toshinori , ISHIDUKA, Yuya , OHTSUBO, Shinya
Abstract: This invention provides a material for adhesion prevention that can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-µm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-µm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
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公开(公告)号：EP1191054B1
公开(公告)日：2007-03-07
申请号：EP01917864.9
申请日：2001-04-10
Applicant: TORAY INDUSTRIES, INC.
Inventor： HOCHI, Motonori , TANAKA, Shigeru , HIROTA, Kusato
CPC classification number: C09D7/61 , C08K3/346 , Y10T428/1341 , Y10T428/1359 , Y10T428/1379 , Y10T428/1383 , Y10T428/252 , Y10T428/259 , Y10T428/31667 , Y10T428/31699 , Y10T428/31928
Abstract: A laminated film is provided which is constituted essentially of a resin substrate and a coated film disposed thereon. The coated film comprises a montmorillonite containing a cation exchanger other than sodium ions and a water-soluble polymer. The laminated film offers a high oxygen-permeability barrier at high humidity and firm bonding between the coated film and the resin substrate at high humidity. A packaging material derived from the laminated film is also provided.
Abstract translation: 一种层状薄膜，其包含树脂基质并在其上叠加包含含钠离子以外的可交换阳离子的蒙脱石和水溶性聚合物的涂膜。 即使在高湿度的气氛下，该层压膜也具有高氧阻隔性和涂膜与基体之间的高附着性。
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