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公开(公告)号：EP3135315A1
公开(公告)日：2017-03-01
申请号：EP15783466.4
申请日：2015-04-20
Inventor： OKAMURA, Yosuke , NAGASE, Yu , KOMACHI, Takuya , HOCHI, Motonori , SEKIDO, Yuki , ARAKANE, Toru
CPC classification number: A61L31/00 , A61L15/16 , A61L15/24 , A61L15/26 , A61L15/28 , A61L15/64 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/148 , A61L2400/12 , B32B7/045 , B32B9/02 , B32B9/04 , B32B9/045 , B32B27/08 , B32B27/306 , B32B27/36 , B32B2250/05 , B32B2250/24 , B32B2250/44 , B32B2307/7163 , B32B2307/73 , B32B2535/00 , C08L67/04 , C08L5/04 , C08L29/04
Abstract: The present invention provides a polymer laminate in which 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. By the present invention, a polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.
Abstract translation: 本发明提供一种聚合物层叠体，其中层叠2〜100层各自含有生物降解性树脂，厚度为10nm〜400nm的聚合物层叠体，至少一层最外层的厚度为10nm〜180nm， 最外层彼此连接。 通过本发明，可以获得生物相容性和机械强度优异且适用于医疗用途如伤口敷料和防粘附材料的聚合物层压体。
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2.发明授权
公开(公告)号：EP2058353B1
公开(公告)日：2012-02-15
申请号：EP07806534.9
申请日：2007-08-31
Inventor： NAGASE, Yu , SHIMOYAMADA, Naoya , IWASAKI, Yasuhiko , ISHIHARA, Kazuhiko
CPC classification number: C08G73/1046 , C07F9/091 , C08G18/10 , C08G18/3206 , C08G69/26 , C08G73/105 , C08G18/4854 , C08G18/3889
Abstract: Disclosed is a highly polymerizable diamine compound containing a phosphorylcholine group. Also disclosed is a high molecular weight polymer which uses the phosphorylcholine group-containing highly polymerizable diamine compound as one of the starting raw materials and is improved in mechanical strength, water resistance and heat resistance, while maintaining excellent biocompatibility and workability as an MPC polymer. Further disclosed is a method for producing such a high molecular weight polymer. Specifically disclosed is a specific diamine compound represented by the formula (I) below and containing a phosphorylcholine group. Also specifically disclosed is a polymer represented by the formula (II) below and having a number average molecular weight of not less than 5,000, while containing at least 1% by mole of a specific structural unit having a phosphorylcholine group. Further specifically disclosed is a method for producing such a polymer by using the diamine compound as one of the raw materials.
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3.发明公开DIAMINE COMPOUND HAVING PHOSPHORYLCHOLINE GROUP, POLYMER THEREOF AND METHOD FOR PRODUCING THE SAME 有权DI UNG UNG UNG UNG R R R R R R R R R R R R R R R R R R R R R R R R R R R
公开(公告)号：EP2058353A1
公开(公告)日：2009-05-13
申请号：EP07806534.9
申请日：2007-08-31
Inventor： NAGASE, Yu , SHIMOYAMADA, Naoya , IWASAKI, Yasuhiko , ISHIHARA, Kazuhiko
CPC classification number: C08G73/1046 , C07F9/091 , C08G18/10 , C08G18/3206 , C08G69/26 , C08G73/105 , C08G18/4854 , C08G18/3889
Abstract: Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed.
The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol% of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.Abstract translation: 公开了具有磷酸胆碱基团的高度可聚合的二胺化合物。 从具有磷酸胆碱基团的高度可聚合的二胺化合物作为单体获得高分子量聚合物，并且聚合物具有改善的机械强度，耐水性和耐热性，同时保持MPC聚合物的优异的生物相容性和可加工性。 公开了制备聚合物的方法。 具有磷酸胆碱基团的二胺化合物由式（I）表示。 聚合物含有至少1mol％的具有由式（II）表示的磷酸胆碱基团并且数均分子量不小于5,000的特定结构单元。 在该方法中，二胺化合物用作单体。
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