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1.发明公开Acid-resistant fibroblast growth factor composition for treating ulcerating diseases of the gastrointestinal tract 失效耐酸性纤维生长因子成分及治疗胃肠道感染性溃疡的方法
公开(公告)号：EP0360006A3
公开(公告)日：1990-04-04
申请号：EP89115252.2
申请日：1989-08-18
发明人： Folkman, Moses Judah , Kato, Koichi
CPC分类号： C07K14/503 , A61K38/1825 , A61K47/36 , C07K14/501 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928 , Y10S514/97 , A61K31/415 , A61K31/34 , A61K2300/00
摘要： This invention describes pharmaceutical compositions and methods of treating ulcerating diseases of the gastrointestinal tract in mammals with an acid-resistant fibroblast growth factor ccmpositions. Also described is the use of acid-resistant fibroblast growth factor compositions in the treatment of various other fibroblast growth factor-responsive conditions.
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2.发明授权Acid-resistant fibroblast growth factor composition for treating ulcerating diseases of the gastrointestinal tract 失效用于治疗胃肠道引流性溃疡性疾病的耐酸性纤维生长因子组成
公开(公告)号：EP0360006B1
公开(公告)日：1993-07-21
申请号：EP89115252.2
申请日：1989-08-18
发明人： Folkman, Moses Judah , Kato, Koichi
CPC分类号： C07K14/503 , A61K38/1825 , A61K47/36 , C07K14/501 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928 , Y10S514/97 , A61K31/415 , A61K31/34 , A61K2300/00
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3.发明公开Acid-resistant fibroblast growth factor composition for treating ulcerating diseases of the gastrointestinal tract 失效Sauerwiderstehender Fibroblast-Wachstumsfaktor，Zubereitung zur Behandlung von Magen-Darmweg-Geschwürkrankheiten。
公开(公告)号：EP0360006A2
公开(公告)日：1990-03-28
申请号：EP89115252.2
申请日：1989-08-18
发明人： Folkman, Moses Judah , Kato, Koichi
CPC分类号： C07K14/503 , A61K38/1825 , A61K47/36 , C07K14/501 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928 , Y10S514/97 , A61K31/415 , A61K31/34 , A61K2300/00
摘要： This invention describes pharmaceutical compositions and methods of treating ulcerating diseases of the gastrointestinal tract in mammals with an acid-resistant fibroblast growth factor ccmpositions. Also described is the use of acid-resistant fibroblast growth factor compositions in the treatment of various other fibroblast growth factor-responsive conditions.
摘要翻译： 本发明描述了具有耐酸性成纤维细胞生长因子的哺乳动物的胃肠道溃疡性疾病的药物组合物和方法。 还描述了耐酸成纤维细胞生长因子组合物在治疗各种其它成纤维细胞生长因子反应条件中的用途。
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公开(公告)号：EP0357061A1
公开(公告)日：1990-03-07
申请号：EP89116053.3
申请日：1989-08-31
IPC分类号： A61K31/335
CPC分类号： C07D303/22 , A61K31/335 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/14 , C07D407/14 , C07D417/14
摘要： O-substituted fumagillol derivatives and its salts have an angiogenesis inhibiting activity and are useful for prophylaxis and treatment of diseases induced by abnormally stimulated neovascularization.
摘要翻译： O-取代的烟曲霉醇衍生物及其盐具有血管生成抑制活性，可用于预防和治疗由异常刺激的新血管形成引起的疾病。
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公开(公告)号：EP0357061B1
公开(公告)日：1994-06-08
申请号：EP89116053.3
申请日：1989-08-31
IPC分类号： A61K31/335
CPC分类号： C07D303/22 , A61K31/335 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/14 , C07D407/14 , C07D417/14
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公开(公告)号：EP1927359A3
公开(公告)日：2008-06-11
申请号：EP08002915.0
申请日：1994-08-02
IPC分类号： A61K31/56 , C07J41/00 , C07J31/00 , C07J13/00 , C07J9/00 , C07J5/00 , C07J7/00 , C07J63/00 , C07J1/00
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The applications discloses the treatment of inflammatory disorders, in particular those associated with rheumatoid, arthritis, gout, gouty arthritis and Behcet's syndrome, with 2-methoxyestradiol.
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公开(公告)号：EP0312246B1
公开(公告)日：1994-11-30
申请号：EP88309273.6
申请日：1988-10-05
CPC分类号： A61K35/44 , A01N1/0205 , A01N1/0226
摘要： A purified inhibitor of capillary endothelial cell growth and of angiogenesis is obtainable from the bovine cornea.
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公开(公告)号：EP0312246A2
公开(公告)日：1989-04-19
申请号：EP88309273.6
申请日：1988-10-05
CPC分类号： A61K35/44 , A01N1/0205 , A01N1/0226
摘要： A purified inhibitor of capillary endothelial cell growth and of angiogenesis is obtainable from the bovine cornea.
摘要翻译： 毛细血管内皮细胞生长和血管发生的纯化抑制剂可从牛角膜获得。
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公开(公告)号：EP0482623B1
公开(公告)日：1995-05-10
申请号：EP91118120.4
申请日：1991-10-24
发明人： Folkman, Moses Judah , Shing, Yuen
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A61K38/00
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公开(公告)号：EP0482623A2
公开(公告)日：1992-04-29
申请号：EP91118120.4
申请日：1991-10-24
发明人： Folkman, Moses Judah , Shing, Yuen
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel growth factor (BTC-CG) was purified from the conditioned medium of pancreatic beta tumor cells initially derived from transgenic mice (RIP1-Tag2). The purification scheme included BioRex 70 chromatography, phenyl-Sepharose chromatography, TSL-GEL heparin FPLC and C4 reverse phase HPLC. The peptide also stimulated proliferation of bovine smooth muscle cells. It was not inactivated by boiling, by 10 mM dithiothreitol or by exposure to 1 M acetic acid. Biological activity of BTC-GF was recovered from a single band of protein which had a molecular weight of 32,000 on SDS-PAGE. The partial N-terminal amino acid sequence of this protein from BTC-3 and BTC-J10 cells was determined with an ABI 470A protein sequencer to be:
摘要翻译： 从最初衍生自转基因小鼠（RIP1-Tag2）的胰腺β细胞的细胞培养基中纯化出新的生长因子（BTC-CG）。 纯化方案包括BioRex 70色谱，苯基琼脂糖层析，TSL-GEL肝素FPLC和C4反相HPLC。 该肽还刺激了牛平滑肌细胞的增殖。 通过煮沸，10mM二硫苏糖醇或通过暴露于1M乙酸不灭活。 从SDS-PAGE上分子量为32,000的单一蛋白质带中回收BTC-GF的生物活性。 使用ABI 470A蛋白质测序仪测定来自BTC-3和BTC-J10细胞的该蛋白质的部分N-末端氨基酸序列：
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