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公开(公告)号：EP4066893A1
公开(公告)日：2022-10-05
申请号：EP20891800.3
申请日：2020-11-26
发明人： ITO, Yoshiteru , MIYANOHANA, Yuhei , KAJITA, Yuichi , HOASHI, Yasutaka , HATTORI, Yasushi , KOIKE, Tatsuki , TOKUNAGA, Norihito , KIMURA, Eiji , PAWLICZEK, Alexander Martin , PIRA, Marilena , MIGUELEZ-RAMOS, Javier
IPC分类号： A61P3/04 , A61P5/50 , A61P9/04 , A61P19/08 , A61P23/00 , A61P25/16 , A61P25/20 , A61P25/26 , A61P25/28 , A61P43/00 , C07D455/02 , C07D471/04 , A61K31/4375 , A61K31/444
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：EP3660003A1
公开(公告)日：2020-06-03
申请号：EP18838990.2
申请日：2018-07-26
发明人： KIMURA, Eiji , OGINO, Masaki , KOHARA, Yasuhisa , OHASHI, Tomoko , KAKU, Tomohiro , OGURO, Yuya , MATSUMOTO, Shigemitsu , WAKABAYASHI, Takeshi , TOKUNAGA, Norihito , KAMEI, Taku , ITO, Mitsuhiro
IPC分类号： C07D231/56 , A61K31/4162 , A61K31/4184 , A61K31/4192 , A61K31/4439 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D235/06 , C07D235/08 , C07D249/18 , C07D401/12 , C07D409/12
摘要： Provided is a heterocyclic compound that can have an antagonistic action on an NMDA receptor containing the NR2B subunit, and is expected to be useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I):
wherein each symbol is as described in the DESCRIPTION, or a salt thereof.-
公开(公告)号：EP3156397A1
公开(公告)日：2017-04-19
申请号：EP15806591.2
申请日：2015-06-11
发明人： OGINO, Masaki , KIMURA, Eiji , SUZUKI, Shinkichi , ASHIZAWA, Tomoko , IMAEDA, Toshihiro , FUJIMORI, Ikuo , ARAI, Ryosuke
IPC分类号： C07D213/81 , A61K31/44 , A61K31/4439 , A61K31/444 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/28 , A61P43/00 , C07D401/10 , C07D401/14 , C07D405/12 , C07D405/14
CPC分类号： C07D401/10 , A61K31/44 , A61K31/4439 , A61K31/444 , C07D213/81 , C07D401/14 , C07D405/12 , C07D405/14
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as a medicament such as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof.
wherein each symbol is as described in the attached DESCRIPTION.摘要翻译： 本发明提供具有胆碱能毒蕈碱M1受体正变构调节剂活性的化合物，作为阿尔茨海默病，精神分裂症，疼痛，睡眠障碍，帕金森病痴呆，路易体痴呆等的预防或治疗药物有用 等等。 本发明涉及由式（I）表示的化合物或其盐。 其中每个符号如所附描述中所述。
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公开(公告)号：EP2982670A1
公开(公告)日：2016-02-10
申请号：EP14779878.9
申请日：2014-04-03
发明人： KOIKE, Tatsuki , YOSHIKAWA, Masato , NOMURA, Izumi , ITO, Yoshiteru , KIMURA, Eiji , ANDO, Haruhi , HASUI, Tomoaki , NISHI, Toshiya
IPC分类号： C07D263/32 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/5386 , A61K31/553 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D491/08
CPC分类号： C07D263/32 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D491/08
摘要： The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.
摘要翻译： 本发明涉及由式（I）表示的化合物，其可用作预防或治疗癫痫，神经退行性疾病等的药剂。 在式（I）中，每个符号如说明书中所定义。
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公开(公告)号：EP2933247B1
公开(公告)日：2018-08-29
申请号：EP13862252.7
申请日：2013-12-10
发明人： KOIKE, Tatsuki , KAJITA, Yuichi , YOSHIKAWA, Masato , IKEDA, Shuhei , KIMURA, Eiji , HASUI, Tomoaki , NISHI, Toshiya , FUKUDA, Hiromi
IPC分类号： C07D401/14 , C07D213/72 , C07D239/42 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/444 , A61K31/46 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00
CPC分类号： C07D498/08 , A61K9/2018 , A61K9/4858 , C07D213/12 , C07D213/72 , C07D213/74 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/02 , C07D451/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/18 , C07D491/08 , C07D491/18 , C12N9/99
摘要： An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.
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6.发明公开2,3-DIHYDRO-4H-1,3-BENZOXAZIN-4-ONE DERIVATIVES AS MODULATORS OF CHOLINERGIC MUSCARINIC M1 RECEPTOR 审中-公开2,3-二氢-4H-1,3-苯并恶嗪-4-酮衍生物作为胆碱能受体M1受体调节剂
公开(公告)号：EP3313836A1
公开(公告)日：2018-05-02
申请号：EP16756814.6
申请日：2016-06-23
发明人： SUGIMOTO, Takahiro , SUZUKI, Shinkichi , SAKAMOTO, Hiroki , YAMADA, Masami , NAKAMURA, Minoru , KAMATA, Makoto , SHIMOKAWA, Kenichiro , OGINO, Masaki , KIMURA, Eiji , MURAKAMI, Masataka , YONEMORI, Jinichi , KOJIMA, Takuto
IPC分类号： C07D413/14 , C07D413/10 , C07D413/06 , C07D413/04 , C07D417/06 , C07D265/22 , C07D471/04 , C07D491/107 , A61P25/00 , A61K31/536 , A61K31/541 , A61P29/00
摘要： wherein each symbol is as defined in the attached DESCRIPTION.
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公开(公告)号：EP3239150A1
公开(公告)日：2017-11-01
申请号：EP15873002.8
申请日：2015-12-21
发明人： KIMURA, Eiji , MIYANOHANA, Yuhei , OGINO, Masaki , TANAKA, Yuta , FUSHIMI, Makoto , OKAWA, Tomohiro , HANYA, Yuki , KOIKE, Tatsuki
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/4985 , A61K31/506 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D487/04
CPC分类号： C07D471/04 , A61P25/00 , A61P29/00 , C07D487/04
摘要： Provided is a compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and is useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I) :
wherein each symbol is as described in the DESCRIPTION, (excluding N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(imidazo[1,2-a]pyridin-5-yl)acetamide) or a salt thereof.摘要翻译： 本发明提供对含有NR2B亚基的NMDA受体具有拮抗作用的化合物，作为重症抑郁症，双相型障碍，偏头痛，疼痛，痴呆症的周边症状等的预防或治疗剂是有用的。 由式（I）表示的化合物：其中每个符号如描述中所述，（不包括N-（4-溴-3-（1H-1,2,4-三唑-5-基）噻吩-2-基） （咪唑并[1,2-a]吡啶-5-基）乙酰胺）或其盐。
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8.发明授权
公开(公告)号：EP3313836B1
公开(公告)日：2020-11-11
申请号：EP16756814.6
申请日：2016-06-23
发明人： SUGIMOTO, Takahiro , SUZUKI, Shinkichi , SAKAMOTO, Hiroki , YAMADA, Masami , NAKAMURA, Minoru , KAMATA, Makoto , SHIMOKAWA, Kenichiro , OGINO, Masaki , KIMURA, Eiji , MURAKAMI, Masataka , YONEMORI, Jinichi , KOJIMA, Takuto
IPC分类号： C07D413/14 , C07D413/10 , C07D413/06 , C07D413/04 , C07D417/06 , C07D265/22 , C07D471/04 , C07D491/107 , A61P25/00 , A61K31/536 , A61K31/541 , A61P29/00
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公开(公告)号：EP3239150B1
公开(公告)日：2020-02-05
申请号：EP15873002.8
申请日：2015-12-21
发明人： KIMURA, Eiji , MIYANOHANA, Yuhei , OGINO, Masaki , TANAKA, Yuta , FUSHIMI, Makoto , OKAWA, Tomohiro , HANYA, Yuki , KOIKE, Tatsuki
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4985 , A61P25/00 , A61P29/00
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公开(公告)号：EP3156397B1
公开(公告)日：2019-08-07
申请号：EP15806591.2
申请日：2015-06-11
发明人： OGINO, Masaki , KIMURA, Eiji , SUZUKI, Shinkichi , ASHIZAWA, Tomoko , IMAEDA, Toshihiro , FUJIMORI, Ikuo , ARAI, Ryosuke
IPC分类号： C07D213/81 , A61K31/44 , A61K31/4439 , A61K31/444 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/28 , A61P43/00 , C07D401/10 , C07D401/14 , C07D405/12 , C07D405/14
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