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1.发明公开ANTI-ADHESION MATERIAL AND ARTIFICIAL BIOLOGICAL MEMBRANE EACH COMPRISING DECELLULARIZED TISSUE 审中-公开包含去纤维组织的抗粘附材料和人造生物膜
公开(公告)号：EP3269402A1
公开(公告)日：2018-01-17
申请号：EP16761714.1
申请日：2016-03-07
申请人： The Chemo-Sero-Therapeutic Research Institute , Adeka Corporation , National University Corporation Tokyo Medical and Dental University , Sapporo Medical University
发明人： SAGA, Hideki , UCHIDA, Takanori , TOKOROZAKI, Shoko , HIWATARI, Ken-Ichiro , OBARA, Haruki , KISHIDA, Akio , KIMURA, Tsuyoshi , NEGISHI, Jun , HIGAMI, Tetsuya , FUNAMOTO, Seiichi
IPC分类号： A61L31/00
CPC分类号： A61L31/046 , A61L24/106 , A61L31/005 , A61L31/10 , A61L2300/424
摘要： An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.
摘要翻译： 包含脱细胞组织和生物相容性聚合物或纤维蛋白胶的抗粘连材料; 制备抗粘连材料的方法，所述方法包括将生物相容性聚合物或纤维蛋白胶与脱细胞组织复合; 包含脱细胞组织和生物相容性聚合物或纤维蛋白胶的抗粘连材料试剂盒; 包含去细胞组织和生物相容性聚合物或纤维蛋白胶的替代生物膜; 制备替代生物膜的方法，其包括将生物相容性聚合物或纤维蛋白胶与脱细胞组织复合; 以及包含去细胞组织和生物相容性聚合物或纤维蛋白胶的替代生物膜试剂盒。
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公开(公告)号：EP0634140A1
公开(公告)日：1995-01-18
申请号：EP94911768.3
申请日：1993-09-24
CPC分类号： A61B17/00491 , A61B2017/00495 , A61L26/0061
摘要： An applicator for spraying tissue adhesive onto an affected portion comprises: a sterilized gas supply chamber; a sterilized gas supply pipe connected to the sterilized gas supply chamber; two sterilized gas injection nozzles for injecting the sterilized gas supplied to the sterilized gas supply chamber in the substantially same direction; two barrel connecting ports, to which forward end nozzles of the barrels are connected; and a spray head having two liquid pipes whose base end portions are connected to the barrel connecting ports and which pass through the sterilized gas supply chamber and project at the forward end portions thereof from the injection nozzles. In this applicator, coating solutions supplied from syringes of the two barrel connecting ports are injected from the forward end portions of the liquid pipes, the sterilized gases are injected from the two gas nozzles in the substantially same direction, and the two types of liquid injected from the liquid pipes are atomized and applied onto the affected portion in a mixed state.
摘要翻译： 用于将组织粘合剂喷射到受影响部分上的施加器包括：灭菌气体供应室; 与灭菌气体供给室连接的无菌气体供给管; 两个无菌气体注射喷嘴，用于沿基本相同的方向喷射供应到灭菌气体供应室的灭菌气体; 两个桶连接端口连接到桶的前端喷嘴; 以及喷头，其具有两个液体管，其基端部连接到筒连接口，并且通过无菌气体供应室并从其喷嘴的前端突出。 在这种涂抹器中，从两个管连接口的注射器提供的涂层溶液从液体管的前端部分注入，从两个气体喷嘴沿基本相同的方向注入灭菌气体，注入两种类型的液体 从液体管道被雾化并以混合状态施加到受影响部分。
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公开(公告)号：EP1588722A1
公开(公告)日：2005-10-26
申请号：EP04702784.2
申请日：2004-01-16
CPC分类号： A61L15/32 , A61F13/36 , A61F2013/00472 , A61L15/26 , A61L2400/04 , Y10T442/2508 , Y10T442/2525 , Y10T442/2861 , Y10T442/696 , C08L65/04
摘要： A safe and effective hemostatic material is provided. A hemostatic material comprising as an effective ingredient thrombin and fibrinogen characterized in that a bioabsorbable synthetic nonwoven fabric is used as a supporting material. The use of the hemostatic material of the present invention allows for quick and thorough hemostasis for both projectile bleeding and exudative bleeding.
摘要翻译： 提供安全有效的止血材料。 一种止血材料，其包含作为有效成分的凝血酶和纤维蛋白原，其特征在于使用生物可吸收的合成非织造织物作为支持材料。 使用本发明的止血材料可以快速和彻底地止血用于射弹出血和渗出性出血。
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公开(公告)号：EP2944330A1
公开(公告)日：2015-11-18
申请号：EP13871129.6
申请日：2013-12-17
CPC分类号： A61F2/82 , A61F2/06 , A61F2/062 , A61F2230/0069 , A61F2240/002 , A61L27/3625 , A61L27/3683 , A61L27/507 , A61L27/54 , A61L2300/252 , Y10T156/1038 , A61L27/34 , C08L89/00
摘要： An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.
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公开(公告)号：EP2638868A1
公开(公告)日：2013-09-18
申请号：EP11839105.1
申请日：2011-11-07
发明人： SUZUKI, Zenetsu , IKEDA, Masao , UCHIDA, Takanori , ICHIKI, Osamu , OKA, Shirou
CPC分类号： A61B17/00491 , A61B2017/00495 , B05B7/0475 , B05B7/0491 , B05B7/0876 , B05B7/2429 , B05B7/2472 , B05B11/02
摘要： An adhesive applicator for biological tissue (100) includes a nozzle body (1), a gas inlet (2), medical fluid inlets (3a, 3b), medical fluid outlets (4a, 4b), medical fluid tubes (5a, 5b), a gas outlet (6), communication paths (8a, 8b), and a check valve (7b). The gas outlet (6) is located close to the medical fluid outlets (4a, 4b), and configured to eject gas loaded through the gas inlet (2) in the nozzle body (1) to thereby atomize medical fluids and mix them together. The communication paths (8a, 8b) communicate between inside of the nozzle body (1) and inside of the medical fluid tube (5b) . The check valve (7b) is located between the communication paths (8a, 8b) and the medical fluid inlet (3b). The check valve (7b) only allows one-way flow of the medical fluid from the medical fluid inlet (3b) into the medical fluid tube (5b) .
摘要翻译： 用于生物组织（100）的粘合剂施加器包括喷嘴体（1），气体入口（2），医用流体入口（3a，3b），医用流体出口（4a，4b），医用流体管（5a，5b） ，气体出口（6），连通路径（8a，8b）和止回阀（7b）。 气体出口（6）位于医疗流体出口（4a，4b）附近，并且构造成喷射通过喷嘴体（1）中的气体入口（2）装载的气体，从而雾化医用流体并将它们混合在一起。 通路（8a，8b）在喷嘴体（1）的内部和医用流体管（5b）的内部连通。 止回阀（7b）位于连通通路（8a，8b）和医用流体入口（3b）之间。 止回阀（7b）仅允许医用流体从医用流体入口（3b）单向流入医用流体管（5b）。
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公开(公告)号：EP0835667B1
公开(公告)日：2005-11-09
申请号：EP97907319.4
申请日：1997-03-14
IPC分类号： A61L24/10
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , Y10S514/822
摘要： A tissue adhesive capable of forming fibrins uniformly at high density, and exhibiting marked closing effect. This tissue adhesive is mixed with an aseptic gas and the mixture is applied to tissue. The tissue adhesive comprises separated fibrinogen solution and thrombin solution. The volume ratio of the fibrinogen solution to the thrombin solution is 2:1-10:1. This tissue adhesive is used to stick living tissue of a human being or an animal or to close the same.
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公开(公告)号：EP0634140B2
公开(公告)日：2004-08-04
申请号：EP94911768.3
申请日：1993-09-24
CPC分类号： A61B17/00491 , A61B2017/00495 , A61L26/0061
摘要： An applicator for spraying tissue adhesive onto an affected portion comprises: a sterilized gas supply chamber; a sterilized gas supply pipe connected to the sterilized gas supply chamber; two sterilized gas injection nozzles for injecting the sterilized gas supplied to the sterilized gas supply chamber in the substantially same direction; two barrel connecting ports, to which forward end nozzles of the barrels are connected; and a spray head having two liquid pipes whose base end portions are connected to the barrel connecting ports and which pass through the sterilized gas supply chamber and project at the forward end portions thereof from the injection nozzles. In this applicator, coating solutions supplied from syringes of the two barrel connecting ports are injected from the forward end portions of the liquid pipes, the sterilized gases are injected from the two gas nozzles in the substantially same direction, and the two types of liquid injected from the liquid pipes are atomized and applied onto the affected portion in a mixed state.
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公开(公告)号：EP0634140B1
公开(公告)日：1999-03-17
申请号：EP94911768.3
申请日：1993-09-24
CPC分类号： A61B17/00491 , A61B2017/00495 , A61L26/0061
摘要： An applicator for spraying tissue adhesive onto an affected portion comprises: a sterilized gas supply chamber; a sterilized gas supply pipe connected to the sterilized gas supply chamber; two sterilized gas injection nozzles for injecting the sterilized gas supplied to the sterilized gas supply chamber in the substantially same direction; two barrel connecting ports, to which forward end nozzles of the barrels are connected; and a spray head having two liquid pipes whose base end portions are connected to the barrel connecting ports and which pass through the sterilized gas supply chamber and project at the forward end portions thereof from the injection nozzles. In this applicator, coating solutions supplied from syringes of the two barrel connecting ports are injected from the forward end portions of the liquid pipes, the sterilized gases are injected from the two gas nozzles in the substantially same direction, and the two types of liquid injected from the liquid pipes are atomized and applied onto the affected portion in a mixed state.
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