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公开(公告)号：EP2995326A1
公开(公告)日：2016-03-16
申请号：EP14795291.5
申请日：2014-05-02
申请人： The Chemo-Sero-Therapeutic Research Institute , National University Corporation Tokyo Medical and Dental University , Sapporo Medical University , ADEKA CORPORATION
发明人： MATSUDA, Junichi , MIYABASHIRA, Sumika , HARANO, Satomi , KISHIDA, Akio , KIMURA, Tsuyoshi , NEGISHI, Jun , HIGAMI, Tetsuya , FUNAMOTO, Seiichi , HIWATARI, Ken-ichiro , TASAKI, Akiko
IPC分类号： A61L27/00 , A61K9/06 , A61K35/12 , A61K35/28 , A61K35/30 , A61K35/34 , A61K35/407 , A61K35/42 , A61K38/43 , A61K38/48 , A61P9/10
CPC分类号： A61L27/52 , A61K35/22 , A61K35/30 , A61K35/34 , A61K35/407 , A61K35/42 , A61K38/363 , A61K38/4833 , A61L27/225 , A61L27/26 , A61L27/3633 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L27/54 , A61L2430/00 , A61L2430/20 , A61L2430/32 , C12N5/0068 , C12N2533/50 , C12N2533/56 , C12N2533/90
摘要： A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.
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2.发明公开ANTI-ADHESION MATERIAL AND ARTIFICIAL BIOLOGICAL MEMBRANE EACH COMPRISING DECELLULARIZED TISSUE 审中-公开包含去纤维组织的抗粘附材料和人造生物膜
公开(公告)号：EP3269402A1
公开(公告)日：2018-01-17
申请号：EP16761714.1
申请日：2016-03-07
申请人： The Chemo-Sero-Therapeutic Research Institute , Adeka Corporation , National University Corporation Tokyo Medical and Dental University , Sapporo Medical University
发明人： SAGA, Hideki , UCHIDA, Takanori , TOKOROZAKI, Shoko , HIWATARI, Ken-Ichiro , OBARA, Haruki , KISHIDA, Akio , KIMURA, Tsuyoshi , NEGISHI, Jun , HIGAMI, Tetsuya , FUNAMOTO, Seiichi
IPC分类号： A61L31/00
CPC分类号： A61L31/046 , A61L24/106 , A61L31/005 , A61L31/10 , A61L2300/424
摘要： An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.
摘要翻译： 包含脱细胞组织和生物相容性聚合物或纤维蛋白胶的抗粘连材料; 制备抗粘连材料的方法，所述方法包括将生物相容性聚合物或纤维蛋白胶与脱细胞组织复合; 包含脱细胞组织和生物相容性聚合物或纤维蛋白胶的抗粘连材料试剂盒; 包含去细胞组织和生物相容性聚合物或纤维蛋白胶的替代生物膜; 制备替代生物膜的方法，其包括将生物相容性聚合物或纤维蛋白胶与脱细胞组织复合; 以及包含去细胞组织和生物相容性聚合物或纤维蛋白胶的替代生物膜试剂盒。
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公开(公告)号：EP2995326B1
公开(公告)日：2019-07-24
申请号：EP14795291.5
申请日：2014-05-02
申请人： KM Biologics Co., Ltd. , National University Corporation Tokyo Medical and Dental University , Sapporo Medical University , ADEKA CORPORATION
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公开(公告)号：EP2995325A1
公开(公告)日：2016-03-16
申请号：EP14794303.9
申请日：2014-05-02
IPC分类号： A61L27/00
摘要： A particulate decellularized tissue is provided which shows sufficiently effective tissue regeneration and does not show cytotoxicity when used as material for cell culture. In accordance with the method for preparing a particulate decellularized tissue comprising a step of applying a high hydrostatic pressure to animal-derived tissues in a medium, a particulate decellularized tissue is obtained which does not show cytotoxicity but shows the effect of cellular attraction and the effect of induction of cellular differentiation and shows a high effect of tissue regeneration.
摘要翻译： 提供颗粒脱细胞组织，其显示足够有效的组织再生，并且当用作细胞培养物质时不显示细胞毒性。 根据制备颗粒状脱细胞组织的方法，该方法包括对培养基中的动物衍生组织施加高静水压力的步骤，获得颗粒状脱细胞组织，其不显示细胞毒性但显示出细胞吸引的效果和效果 诱导细胞分化并显示出高的组织再生效果。
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公开(公告)号：EP2944330A1
公开(公告)日：2015-11-18
申请号：EP13871129.6
申请日：2013-12-17
CPC分类号： A61F2/82 , A61F2/06 , A61F2/062 , A61F2230/0069 , A61F2240/002 , A61L27/3625 , A61L27/3683 , A61L27/507 , A61L27/54 , A61L2300/252 , Y10T156/1038 , A61L27/34 , C08L89/00
摘要： An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.
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公开(公告)号：EP2335917B1
公开(公告)日：2014-04-30
申请号：EP09816213.4
申请日：2009-09-25
发明人： HANAWA, Takao , TSUTSUMI, Yusuke , NAM, Kwangwoo , KISHIDA, Akio , KOBAYASHI, Hisatoshi , YOSHIKAWA, Chiaki
IPC分类号： A61L27/00 , A61L27/04 , B05D1/18 , B05D1/28 , B82Y30/00 , B82Y40/00 , C09D5/44 , C08F292/00 , C25D11/16 , C25D11/26 , A61L27/34
CPC分类号： A61L27/34 , A61L27/04 , B05D1/185 , B05D1/283 , B05D2202/35 , B82Y30/00 , B82Y40/00 , C08F292/00 , C09D5/4476 , C25D11/16 , C25D11/26 , Y10T428/24752 , C08F220/28
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8.发明公开POLYMER BRUSH COMPOSITE AND METHOD FOR PRODUCING SAME 有权VERFAHREN ZU SEINER HERSTELLUNG的POLYMERBÜRSTENVERBUNDSTOFF
公开(公告)号：EP2335917A1
公开(公告)日：2011-06-22
申请号：EP09816213.4
申请日：2009-09-25
发明人： HANAWA, Takao , TSUTSUMI, Yusuke , NAM, Kwangwoo , KISHIDA, Akio , KOBAYASHI, Hisatoshi , YOSHIKAWA, Chiaki
IPC分类号： B32B15/04 , A61L27/00 , B32B9/00 , H01L21/312 , H01L21/316
CPC分类号： A61L27/34 , A61L27/04 , B05D1/185 , B05D1/283 , B05D2202/35 , B82Y30/00 , B82Y40/00 , C08F292/00 , C09D5/4476 , C25D11/16 , C25D11/26 , Y10T428/24752 , C08F220/28
摘要： Disclosed is a polymer brush composite including a substrate, a solid layer disposed on the substrate and containing at least one of a metal or a metal oxide, and a plurality of polymer chains penetrating the solid layer in such a manner that one end of each of the polymer chains is disposed on the upper side of the substrate and the other end of each the polymer chains is exposed at a surface of the solid layer on an opposite side of the solid layer to the substrate. The polymer brush composite exhibits good adhesion between an organic polymer compound and an inorganic material and has the surface the organic polymer compound and the inorganic material uniformly coexist.
摘要翻译： 公开了一种聚合物刷复合体，其包括基材，设置在基材上的固体层，并且包含金属或金属氧化物中的至少一种，以及穿透固体层的多个聚合物链， 聚合物链设置在基材的上侧，并且每个聚合物链的另一端在固体层的与固体层的相对侧的表面上暴露于基材。 聚合物刷复合物在有机高分子化合物和无机材料之间表现出良好的粘附性，并且表面有机高分子化合物和无机材料均匀共存。
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公开(公告)号：EP2138181B1
公开(公告)日：2016-05-04
申请号：EP08721624.8
申请日：2008-03-07
申请人： National University Corporation Tokyo Medical and Dental University , National Cerebral and Cardiovascular Center
CPC分类号： A61K35/12 , A61K35/44 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L2430/40 , C12N5/0068 , C12N2533/90
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10.发明公开METHOD OF PREPARING DECELLULARIZED SOFT TISSUE, GRAFT AND CULTURE MATERIAL 有权VERFAHREN ZUR HERSTELLUNG VON ENTZELLULARISIERTEM WEICHGEWEBE，
公开(公告)号：EP2138181A1
公开(公告)日：2009-12-30
申请号：EP08721624.8
申请日：2008-03-07
申请人： National University Corporation Tokyo Medical and Dental University , Japan as represented by president of National Cardiovascular Center
CPC分类号： A61K35/12 , A61K35/44 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L2430/40 , C12N5/0068 , C12N2533/90
摘要： It is intended to provide a method of preparing a decellularized soft tissue whereby swelling after an ultrahigh pressure treatment can be inhibited, etc. The above-described method of preparing a decellularized soft tissue comprises the application step wherein an ultrahigh hydrostatic pressure is applied to an isolated soft tissue in a medium to thereby disrupt cells in the soft tissue, and the removal step wherein the disrupted cells are removed. As the medium, use is made of an aqueous solution containing a water-soluble polysaccharide such as dextran.
摘要翻译： 旨在提供一种制备脱细胞软组织的方法，从而可以抑制超高压处理后的膨胀等。上述制备脱细胞软组织的方法包括施加步骤，其中将超高静水压力施加到 在培养基中分离软组织，从而破坏软组织中的细胞，以及去除步骤，其中去除细胞。 作为介质，使用含有水溶性多糖如葡聚糖的水溶液。
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