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    METHOD FOR QUANTIFICATION OF TITER OF NEUROTOXIN-NEUTRALIZING ANTIBODY
    1.
    发明公开
    METHOD FOR QUANTIFICATION OF TITER OF NEUROTOXIN-NEUTRALIZING ANTIBODY 有权
    定量测定神经毒素中和抗体滴度的方法

    公开(公告)号：EP2189790A1

    公开(公告)日：2010-05-26

    申请号：EP08827849.4

    申请日：2008-08-20

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute ,  JAPAN as represented by DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES

    发明人： TORII, Yasushi ,  HARAKAWA, Tetsuhiro ,  GOTO, Yoshitaka ,  GINNAGA, Akihiro ,  KAJI, Ryuji ,  KOZAKI, Shunji ,  TAKAHASHI, Motohide

    IPC分类号： G01N33/48 ,  G01N33/15

    CPC分类号： G01N33/6854 ,  A61B5/0488 ,  G01N2333/33 ,  G01N2469/20

    摘要： A method for quantification of a titer of a neutralizing antibody to a neurotoxin is disclosed. The method comprises the steps: (a) mixing a standard sample containing a fixed amount of a neurotoxin and a test sample containing a neutralizing antibody to said neurotoxin; (b) administering the mixture obtained in step (a) into the muscle of a non-human mammal; (c) applying electric stimulus to said non-human mammal; (d) measuring a compound muscle action potential (CMAP) due to contraction of the muscle of said mammal by application of electric stimulus with an electromyograph; and (e) analyzing CMAP amplitude data obtained in step (d) for an extent of decrease in amplitude by a non-neutralized neurotoxin to thereby quantify a titer of the neutralizing antibody contained in the test sample.

    摘要翻译： 公开了定量测定神经毒素中和抗体效价的方法。 该方法包括以下步骤：（a）将含有固定量的神经毒素的标准样品和含有中和抗体的测试样品混合到所述神经毒素中; （b）将步骤（a）中获得的混合物给予非人类哺乳动物的肌肉; （c）对所述非人类哺乳动物施加电刺激; （d）通过用肌电图应用电刺激测量所述哺乳动物肌肉收缩引起的复合肌肉动作电位（CMAP）; 和（e）分析步骤（d）中获得的CMAP幅度数据对于未中和的神经毒素的幅度降低程度，从而定量测试样品中含有的中和抗体的效价。

    PREPARATION OF TYPE A2 BOTULINUM NEUROTOXIN
    6.
    发明公开
    PREPARATION OF TYPE A2 BOTULINUM NEUROTOXIN 有权
    A2肉毒杆菌神经毒素FOR USE肌肉活动在既有的中和TYPE A1抗体治疗

    公开(公告)号：EP2283849A1

    公开(公告)日：2011-02-16

    申请号：EP09726893.2

    申请日：2009-03-31

    申请人： The Chemo-Sero-Therapeutic Research Institute

    发明人： NAKAHIRA, Shinji ,  TORII, Yasushi ,  GOTO, Yoshitaka ,  SHINMURA, Miho ,  MUNECHIKA, Satomi ,  OKUDA, Sachio ,  KOZAKI, Shunji

    IPC分类号： A61K38/00 ,  A61P21/02

    CPC分类号： A61K38/164 ,  A61K38/4893 ,  Y02A50/469

    摘要： A pharmaceutical preparation for use in a patient who has a neutralizing antibody to a botulinum toxin from type A1 Clostridium botulinum (type A1 botulinum toxin), said preparation comprising as an active ingredient 150 kDa type A neurotoxin from type A2 Clostridium botulinum (A2 NTX); a medicament for treating a disease with muscle overactivity for use in a patient who has a neutralizing antibody to a type A1 botulinum toxin, said medicament comprising as an active ingredient said A2 NTX; a method for treating a patient who has a neutralizing antibody to a type A1 botulinum toxin, said method comprising administering said A2 NTX to the patient; and a method for use of A2 NTX in a patient who has said neutralizing antibody. In accordance with the present invention, a problem can be solved of decrease in clinical response caused by a neutralizing antibody to a type A1 botulinum toxin produced when a patient is treated with a pharmaceutical preparation comprising a type A1 botulinum toxin.

    摘要翻译： 用于在患者中谁拥有的中和抗体，以从A1型肉毒梭菌（A1型肉毒杆菌毒素）肉毒毒素的药物制剂，该制剂包括作为活性成分的150 kDa的类型从A2型肉毒杆菌神经毒素（A2 NTX） ; 用于在患者中谁拥有的中和抗体的类型A1的肉毒杆菌毒素治疗的疾病与肌肉活动过度使用的药物，所述药物包含作为活性成分。所述A2 NTX的; 用于治疗患者谁拥有的中和抗体的类型A1的肉毒杆菌毒素的方法，所述方法包括给予所述A2 NTX到患者; 和用于在患者谁拥有所述中和抗体使用A2 NTX的方法。 在本发明雅舞蹈，一个问题可以通过中和抗体引起的到产生当患者用的药物制剂，其包括式A1肉毒毒素处理的A1型肉毒毒素的临床反应来解决降低。