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公开(公告)号：EP1861126A2
公开(公告)日：2007-12-05
申请号：EP06748614.2
申请日：2006-03-22
发明人： ANDERSON, Kenneth, C. , BRADNER, James, Elliott , GREENBERG, Edward, Franklin , HIDESHIMA, Teru , KWIATKOWSKI, Nicholas, Paul , MAZITSCHEK, Ralph , SCHREIBER, Stuart, L. , SHAW, Jared
IPC分类号： A61K51/00 , A61K39/395 , A61K33/36
CPC分类号： A61K38/05 , A61K31/35 , A61K31/357 , A61K31/422 , A61K31/4965 , A61K31/69 , A61K38/50 , A61K45/06 , A61K49/0008 , G01N33/5011 , A61K2300/00
摘要： The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
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2.发明公开
公开(公告)号：EP4037694A1
公开(公告)日：2022-08-10
申请号：EP20870943.6
申请日：2020-10-01
IPC分类号： A61K31/7105 , A61K47/18 , A61K47/32
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公开(公告)号：EP2872125A2
公开(公告)日：2015-05-20
申请号：EP13817396.8
申请日：2013-07-10
IPC分类号： A61K31/136
CPC分类号： C07C223/06 , A61K31/136 , A61K31/15 , A61K31/164 , A61K31/165 , A61K31/216 , A61K31/395 , A61K31/4166 , A61K31/445 , A61K31/655 , A61K31/69 , A61K45/06 , C07C251/48 , C07C251/86 , C07D211/62 , C07D233/80 , A61K2300/00
摘要： The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, tautomers, stereoisomers, solvates, hydrates, polymorphs, and compositions thereof. Also provided are methods and kits involving the inventive compounds for treating proliferative diseases (e.g., cancers (e.g., breast cancer, prostate cancer, lung cancer, and ovarian cancer), benign neoplasms, angiogenesis, inflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound of the invention may enhance the anti-tumor immune response by inhibiting or eliminating the immune suppression mediated by immune suppressor myeloid cells (MDSCs), inducing apoptosis, and/or inhibit or down-regulate proteins (e.g., epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), X-linked inhibitor of apoptosis protein (XIAP), and heat shock protein 90 (Hsp90)) in the subject.
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4.发明授权
公开(公告)号：EP1565193B1
公开(公告)日：2013-04-24
申请号：EP03768749.8
申请日：2003-11-06
IPC分类号： A61K31/198 , A61K31/573 , A61K31/69 , A61K31/704 , A61K38/05 , A61K45/06 , A61P35/00
CPC分类号： A61K31/69 , A61K31/195 , A61K31/198 , A61K31/573 , A61K31/704 , A61K38/05 , A61K45/06 , A61K2300/00
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公开(公告)号：EP1830838A1
公开(公告)日：2007-09-12
申请号：EP05852783.9
申请日：2005-12-02
IPC分类号： A61K31/397 , A61P35/00
CPC分类号： A61K31/407 , A61K31/397 , A61K31/454 , A61K31/573 , A61K31/69 , A61K31/704 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma.
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公开(公告)号：EP3687537A1
公开(公告)日：2020-08-05
申请号：EP18862773.1
申请日：2018-09-26
发明人： BUHRLAGE, Sara , ANDERSON, Kenneth, C. , CHAUHAN, Dharminder , DHE-PAGANON, Sirano , LIU, Xiaoxi , SEO, Hyuk-Soo
IPC分类号： A61K31/44 , A61K31/4436 , A61K31/4439
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公开(公告)号：EP1553939A1
公开(公告)日：2005-07-20
申请号：EP03807949.7
申请日：2003-10-10
IPC分类号： A61K31/427 , A61P35/00
CPC分类号： A61K31/427 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating a warm-blooded animal, especially a human, having myeloma, especially myeloma which is resistant to conventional cytotoxic chemotherapy, comprising administering to said animal a therapeutically effective amount of an epothilone, especially an epothilone of formula (I), to a combination comprising an epothilone, for simultaneous, separate or sequential use; and to a pharmaceutical composition and a commercial package comprising said combination.
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公开(公告)号：EP1432422A2
公开(公告)日：2004-06-30
申请号：EP02777228.4
申请日：2002-09-26
IPC分类号： A61K31/503 , A61K31/57 , A61P35/00
CPC分类号： A61K31/53 , A61K31/501 , A61K31/57 , A61K2300/00
摘要： The present invention relates to the use of a c-kit inhibitor, especially a c-kit inhibitor of formula I, wherein the radicals and symbols have the meanings as defined in the specification, for the preparation of a medicament for the treatment of myeloma, in particular multiple myeloma, especially myeloma which is resistant to conventional chemotherapy; to a combination comprising a c-kit inhibitor and a compound effecting apoptosis of myeloma cells, preferably dexamethasone, for simultaneous, separate or sequential use; to methods of treating myeloma; and to a pharmaceutical composition comprising said combination.
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9.发明授权METHODS OF TREATING MULTIPLE MYELOMA USING COMBINATION THERAPIES BASED ON ANTI-CS1 ANTIBODIES 有权方法多发性骨髓瘤使用组合疗法的基于反-CS1抗体治疗
公开(公告)号：EP2068874B1
公开(公告)日：2015-01-28
申请号：EP07840746.7
申请日：2007-08-07
发明人： AFAR, Daniel , ANDERSON, Kenneth, C. , TAI, Yu-Tzu
IPC分类号： A61K31/454 , A61K31/69 , A61K39/395 , A61P35/00 , A61K38/55
CPC分类号： C07K16/2806 , A61K9/0019 , A61K31/454 , A61K31/573 , A61K31/69 , A61K38/05 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/542 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/732 , A61K2300/00
摘要： Composition suitable for treating multiple myeloma in a subject, comprising a therapeutically effective amount of HuLuc63, a therapeutically effective amount of bortezomib, and a pharmaceutically acceptable carrier, wherein said composition is capable of being administered in a single or multiple dose regimen.
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公开(公告)号：EP1830838B1
公开(公告)日：2012-10-03
申请号：EP05852783.9
申请日：2005-12-02
IPC分类号： A61K31/397 , A61P35/00
CPC分类号： A61K31/407 , A61K31/397 , A61K31/454 , A61K31/573 , A61K31/69 , A61K31/704 , A61K45/06 , A61K2300/00
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