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12 条记录 (耗时 0.016 秒)

    THERAPEUTIC MODULATION OF OCULAR SURFACE LUBRICATION
    4.
    发明公开
    THERAPEUTIC MODULATION OF OCULAR SURFACE LUBRICATION 有权
    治疗调节剂AUGENFLÄCHENBENETZUNG

    公开(公告)号：EP2276496A1

    公开(公告)日：2011-01-26

    申请号：EP09743588.7

    申请日：2009-05-06

    申请人： The Regents of The University of California ,  Schepens Eye Research Institute

    发明人： SULLIVAN, Benjamin ,  SCHMIDT, Tannin, A. ,  SULLIVAN, David, A.

    IPC分类号： A61K31/715 ,  A61K36/00 ,  A61K38/16

    CPC分类号： A61K38/14 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/568 ,  A61K31/685 ,  A61K31/688 ,  A61K31/715 ,  A61K31/728 ,  A61K38/13 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/1841 ,  A61K45/06 ,  A61K47/02 ,  A61K47/24 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent. excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration.

    摘要翻译： 本发明提供了一种药物组合物及其使用方法，用于治疗眼部边界缺乏，与之相关的症状，或与眼表面相关或导致眼部边界缺陷的不良状况。 本发明的药物组合物包含悬浮在眼科可接受的平衡盐溶液中的人PRG4蛋白，润滑剂片段，同系物或同种型。 本发明的药物组合物还可以包含一种或多种选自眼科可接受的抑制剂的眼科可接受的药剂。 赋形剂，收敛剂，血管收缩剂，软化剂，​​透明质酸钠，透明质酸和表面活性磷脂，用于局部给药的药学上可接受的载体中。

    BIOMARKER NORMALIZATION
    5.
    发明公开
    BIOMARKER NORMALIZATION 有权
    生物标志物 - 标准

    公开(公告)号：EP2142905A1

    公开(公告)日：2010-01-13

    申请号：EP08746022.6

    申请日：2008-04-16

    申请人： The Regents of the University of California

    发明人： SULLIVAN, Benjamin

    IPC分类号： G01N13/04

    CPC分类号： G01N13/04

    摘要： In accordance with the invention, a fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.

    EX-VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS
    6.
    发明授权
    EX-VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS 有权

    公开(公告)号：EP2260297B1

    公开(公告)日：2018-08-01

    申请号：EP09755505.6

    申请日：2009-04-03

    申请人： The Regents of the University of California

    发明人： HELLER, Michael ,  SULLIVAN, Benjamin ,  KRISHNAN, Rajaram ,  CARSON, Dennis ,  ESENER, Sadik

    IPC分类号： G01N27/403 ,  G01N27/404 ,  G01N33/49 ,  G01N27/447 ,  B03C5/02

    CPC分类号： B03C5/005 ,  G01N27/447 ,  G01N30/0005 ,  G01N33/491

    摘要： Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures.

    EX-VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS
    7.
    发明公开
    EX-VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS 有权
    多维EX VIVO SYSTEM FOR分离和隔离细胞，囊泡，纳米粒子和生物标志物

    公开(公告)号：EP2260297A2

    公开(公告)日：2010-12-15

    申请号：EP09755505.6

    申请日：2009-04-03

    申请人： The Regents of the University of California

    发明人： HELLER, Michael ,  SULLIVAN, Benjamin ,  KRISHNAN, Rajaram ,  CARSON, Dennis ,  ESENER, Sadik

    IPC分类号： G01N27/403 ,  G01N27/404 ,  G01N33/49

    CPC分类号： B03C5/005 ,  G01N27/447 ,  G01N30/0005 ,  G01N33/491

    摘要： Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of "seamless" sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures.