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公开(公告)号：EP2580320B1
公开(公告)日：2018-08-01
申请号：EP11796321.5
申请日：2011-06-14
发明人： EFE, Jem, A. , KIM, Janghwan , ZHU, Saiyong , HILCOVE, Simon , DING, Sheng
IPC分类号： A61K35/30 , A61K35/33 , A61K35/34 , A61K35/39 , C12N15/85 , C12N5/0793 , C12N5/077 , C12N5/071 , C12N5/073 , C12N5/074 , C12N5/0797
CPC分类号： C12N5/0676 , A61K35/30 , A61K35/33 , A61K35/34 , A61K35/39 , C12N5/0602 , C12N5/0603 , C12N5/0607 , C12N5/0618 , C12N5/0619 , C12N5/0623 , C12N5/0657 , C12N5/0678 , C12N15/85 , C12N2501/01 , C12N2501/155 , C12N2501/235 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/727 , C12N2506/02 , C12N2506/08 , C12N2506/1307 , C12N2510/00
摘要： Methods and compositions for transdifferentiation of an animal cell from (i) a first pluripotent cell fate to a second nonpluripotent cell fate or (ii) from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
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2.发明授权
公开(公告)号：EP2955222B1
公开(公告)日：2018-09-12
申请号：EP15177122.7
申请日：2009-03-17
发明人： SHI, Yan , DESPONTS, Caroline , DING, Sheng , ZHOU, Hongyan , LIN, Tongxiang , LI, Wenlin , ZHU, Saiyong
IPC分类号： C12N5/07
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
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公开(公告)号：EP3199623A1
公开(公告)日：2017-08-02
申请号：EP17160894.6
申请日：2011-03-30
发明人： ZHU, Saiyong , DING, Sheng
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N2501/065 , C12N2501/15 , C12N2501/41 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/727 , C12N2501/73 , C12N2506/03 , C12N2506/094 , C12N2506/28
摘要： The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3'-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
摘要翻译： 本发明提供了用于使用3'-磷酸肌醇依赖性激酶-1（PDK1）活化剂或促进糖酵解代谢的化合物从非多能哺乳动物细胞产生诱导性多能干细胞的方法，组合物和试剂盒，以及 其他小分子。
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公开(公告)号：EP3936608A1
公开(公告)日：2022-01-12
申请号：EP21180031.3
申请日：2011-03-30
发明人： ZHU, Saiyong , DING, Sheng
摘要： The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3'-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
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5.发明公开COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS 有权组合的化学和遗传学方法产生感应多能干细胞
公开(公告)号：EP2955222A1
公开(公告)日：2015-12-16
申请号：EP15177122.7
申请日：2009-03-17
发明人： SHI, Yan , DESPONTS, Caroline , DING, Sheng , ZHOU, Hongyan , LIN, Tongxiang , LI, Wenlin , ZHU, Saiyong
IPC分类号： C12N5/00
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
摘要翻译： 本发明提供了鉴定和使用小分子，以诱导在哺乳动物细胞以及诱导多能性的其它方法多能性。
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6.发明公开COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS 有权组合的化学和遗传学方法产生感应多能干细胞
公开(公告)号：EP2279243A2
公开(公告)日：2011-02-02
申请号：EP09721278.1
申请日：2009-03-17
发明人： SHI, Yan , DESPONTS, Caroline , DING, Sheng , ZHOU, Hongyan , LIN, Tongxiang , LI, Wenlin , ZHU, Saiyong
IPC分类号： C12N5/06
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
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7.发明授权COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS 有权KOMBINIERTE CHEMISCHE UND GENETISCHEANSÄTZEZUR ERZEUGUNG INDUZIERTER PLURIPOTENTER STAMMZELLEN
公开(公告)号：EP2279243B1
公开(公告)日：2016-01-06
申请号：EP09721278.1
申请日：2009-03-17
发明人： SHI, Yan , DESPONTS, Caroline , DING, Sheng , ZHOU, Hongyan , LIN, Tongxiang , LI, Wenlin , ZHU, Saiyong
IPC分类号： C12N5/07
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
摘要翻译： 本发明提供了鉴定和使用小分子以诱导哺乳动物细胞中的多能性以及诱导多能性的其它方法。
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8.发明公开
公开(公告)号：EP2580320A2
公开(公告)日：2013-04-17
申请号：EP11796321.5
申请日：2011-06-14
发明人： EFE, Jem, A. , KIM, Janghwan , ZHU, Saiyong , HILCOVE, Simon , DING, Sheng
IPC分类号： C12N5/16
CPC分类号： C12N5/0676 , A61K35/30 , A61K35/33 , A61K35/34 , A61K35/39 , C12N5/0602 , C12N5/0603 , C12N5/0607 , C12N5/0618 , C12N5/0619 , C12N5/0623 , C12N5/0657 , C12N5/0678 , C12N15/85 , C12N2501/01 , C12N2501/155 , C12N2501/235 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/727 , C12N2506/02 , C12N2506/08 , C12N2506/1307 , C12N2510/00
摘要： Methods and compositions for transdifferentiation of an animal cell from (i) a first pluripotent cell fate to a second nonpluripotent cell fate or (ii) from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
摘要翻译： 本发明通常提供了将动物细胞从第一非多能细胞命运转化为第二非多能细胞命运的方法和组合物。 还提供了用于将动物细胞从非多能中胚层，内胚层或外胚层细胞命运转分化成不同的非多能中胚层，内胚层或外胚层细胞命运的方法和组合物。
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公开(公告)号：EP4438734A2
公开(公告)日：2024-10-02
申请号：EP24181335.1
申请日：2011-06-14
发明人： KIM, Janghwan , ZHU, Saiyong , HILCOVE, Simon , DING, Sheng , EFE, Jem
IPC分类号： C12N15/85
CPC分类号： C12N5/0657 , C12N2501/15520130101 , C12N2501/60220130101 , C12N2501/60320130101 , C12N2501/60420130101 , C12N2501/60620130101 , C12N2506/130720130101 , C12N2510/0020130101 , C12N5/0618 , C12N2501/72720130101 , C12N5/0678 , C12N2501/0120130101 , C12N5/0676 , C12N5/0623
摘要： The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.
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10.发明公开
公开(公告)号：EP3409762A1
公开(公告)日：2018-12-05
申请号：EP18185585.9
申请日：2009-03-17
发明人： SHI, Yan , DESPONTS, Caroline , DING, Sheng , ZHOU, Hongyan , LIN, Tongxiang , LI, Wenlin , ZHU, Saiyong
IPC分类号： C12N5/07
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
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