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公开(公告)号：EP3797860A1
公开(公告)日：2021-03-31
申请号：EP20207659.2
申请日：2016-08-24
摘要： Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers ("DVBM"). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.
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公开(公告)号：EP3057693A1
公开(公告)日：2016-08-24
申请号：EP14853947.1
申请日：2014-10-16
发明人： WALSH, Colin , WILD, Andre , TAYLOR, Robert, James , LEAVER, Timothy , OU, Kevin , RAMSAY, Euan , ANSARI, Aysha
CPC分类号： A61K9/5192 , A61K9/5123 , A61K31/7105 , B01F3/08 , B01F3/0807 , B01F3/0811 , B01F3/0861 , B01F5/02 , B01F13/0062 , B01F13/1022 , B01F2215/0032 , B01J2/06
摘要： Methods and devices for making particles at small volumes.
摘要翻译： 方法和在小体积使颗粒的设备。
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公开(公告)号：EP3262424A1
公开(公告)日：2018-01-03
申请号：EP16756307.1
申请日：2016-02-24
发明人： RAMSAY, Euan , TAYLOR, Robert James , LEAVER, Timothy , WILD, Andre , OU, Kevin , WALSH, Colin
CPC分类号： B01F5/0619 , A61K9/1682 , B01F5/0644 , B01F5/0647 , B01F13/0059 , B01F13/1022 , B01F2005/0623 , B01F2005/0636 , B01F2215/0032 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00855 , B01J2219/00858 , B01J2219/0086 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/00898 , B01J2219/00986 , G01N2015/0038 , G01N2035/00158
摘要： The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.
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公开(公告)号：EP2770980A1
公开(公告)日：2014-09-03
申请号：EP12843980.9
申请日：2012-10-25
发明人： CULLIS, Pieter R. , JIGALTSEV, Igor V. , TAYLOR, James R. , LEAVER, Timothy , WILD, Andre , BELLIVEAU, Nathan Maurice
CPC分类号： B01L3/50273 , A61J3/00 , A61K9/1075 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K9/14 , A61K31/704 , A61K47/44 , A61K49/0002 , B01F3/0807 , B01F5/061 , B01F5/0647 , B01F13/0059 , B01F2005/0636 , B01L3/502715 , B01L2200/0605 , B01L2200/0647 , B01L2300/06 , B01L2300/0848 , B01L2300/0867 , B01L2300/18 , Y10T428/2982
摘要： Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
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5.发明公开LIMIT SIZE LIPID NANOPARTICLES AND RELATED METHODS 审中-公开LIPIDNANOPARTIKEL VON BEGRENZTERGRÖSSEUND VERFAHRENDAFÜR
公开(公告)号：EP3069785A1
公开(公告)日：2016-09-21
申请号：EP16166730.8
申请日：2012-10-25
发明人： CULLIS, Pieter R. , JIGALTSEV, Igor V. , TAYLOR, James R. , LEAVER, Timothy , WILD, Andre , BELLIVEAU, Nathan Maurice
IPC分类号： B01F1/00 , A61K9/127 , A61K9/107 , A61K31/704 , A61K49/00
CPC分类号： B01L3/50273 , A61J3/00 , A61K9/1075 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K9/14 , A61K31/704 , A61K47/44 , A61K49/0002 , B01F3/0807 , B01F5/061 , B01F5/0647 , B01F13/0059 , B01F2005/0636 , B01L3/502715 , B01L2200/0605 , B01L2200/0647 , B01L2300/06 , B01L2300/0848 , B01L2300/0867 , B01L2300/18 , Y10T428/2982
摘要： Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
摘要翻译： 限制大小的脂质纳米颗粒，使用脂质纳米颗粒的方法，以及制备极限大小的脂质纳米颗粒的方法和系统。
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公开(公告)号：EP2761306A1
公开(公告)日：2014-08-06
申请号：EP12837498.0
申请日：2012-09-28
CPC分类号： G01N1/28 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N13/00 , G01N33/00 , Y10T137/0318 , Y10T137/87153
摘要： Methods of determining a first position at which a dispersed phase droplet wets a surface of a channel are provided herein. The methods include immersing the dispersed phase droplet in a continuous phase fluid, wherein the continuous phase fluid is immiscible with the dispersed phase droplet, subsequently flowing the dispersed phase droplet in the continuous phase through the channel at a dispersed phase droplet velocity, wherein the dispersed phase droplet is separated from the surface by a film of the continuous phase fluid having a film thickness, and reducing the film thickness to rupture the film at the first position, wherein the droplet wets the surface at the first position.
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公开(公告)号：EP3915545A1
公开(公告)日：2021-12-01
申请号：EP21169020.1
申请日：2012-10-25
发明人： CULLIS, Pieter R. , JIGALTSEV, Igor V. , TAYLOR, James R. , LEAVER, Timothy , WILD, Andre , BELLIVEAU, Nathan Maurice
IPC分类号： A61K9/127
摘要： Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
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公开(公告)号：EP2971013B1
公开(公告)日：2020-08-19
申请号：EP14785963.1
申请日：2014-03-14
发明人： RAMSAY, Euan , TAYLOR, R. James , WALSH, Colin , BELLIVEAU, Nathan M. , CULLIS, Pieter R. , LEAVER, Timothy , WILD, Andre
IPC分类号： A61P43/00 , A61K9/00 , A61K31/575 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , C12N15/88 , A61K9/51
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公开(公告)号：EP3400097A1
公开(公告)日：2018-11-14
申请号：EP16882817.6
申请日：2016-08-24
CPC分类号： B01F5/0645 , B01F5/064 , B01F5/0655 , B01F5/0656 , B01F13/0059 , B01F2005/0621 , B01F2005/0623 , B01F2215/0422 , B01F2215/0431 , B01F2215/0459
摘要： Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.
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公开(公告)号：EP3288671A1
公开(公告)日：2018-03-07
申请号：EP16787188.8
申请日：2016-04-28
发明人： WILD, Andre , LEAVER, Timothy , WALSH, Colin , HEUCK, Gesine , THOMAS, Anitha , ANSARI, Aysha , OU, Kevin , TAYLOR, R., James , RAMSAY, Euan
CPC分类号： B82Y40/00 , B01F5/061 , B01F5/0644 , B01F5/0647 , B01F13/0059 , B01F13/0064 , B01F2005/0636 , B01L9/527 , B01L2200/025 , B01L2300/0816 , B81B1/00
摘要： The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.
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