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    SKIN GAS MEASUREMENT DEVICE AND SKIN GAS MEASUREMENT METHOD
    1.
    发明公开
    SKIN GAS MEASUREMENT DEVICE AND SKIN GAS MEASUREMENT METHOD 审中-公开
    皮肤气体测量装置和皮肤气体测量方法

    公开(公告)号：EP3006915A1

    公开(公告)日：2016-04-13

    申请号：EP14804477.9

    申请日：2014-05-26

    申请人： NTT Docomo, Inc. ,  The University of Tokyo

    发明人： YAMADA, Yuuki ,  HIYAMA, Satoshi ,  TAKEUCHI, Shoji ,  OKUBO, Tatsuya ,  ITABASHI Keiji

    IPC分类号： G01N1/28 ,  G01N1/22 ,  G01N30/00 ,  G01N30/88 ,  G01N33/497

    CPC分类号： A61B5/443 ,  A61B5/14542 ,  A61B5/441 ,  A61B2010/0083 ,  G01N33/497 ,  G01N2030/062

    摘要： A skin gas measurement device includes a skin gas collecting unit that includes a skin gas collecting space having an opening that is to be attached to a skin surface, a porous material that is for adsorbing and concentrating a skin gas component that is emitted from the skin surface into the skin gas collecting space and that allows the adsorbed skin gas component to be desorbed at a relatively low temperature, and a heater for heating the porous material; and a skin gas measurement unit for measuring the skin gas component that is desorbed from the heated porous material.

    摘要翻译： 本发明提供一种皮肤气体测定装置，其具备：皮肤气体收集部，其具有皮肤气体收集空间，该皮肤气体收集空间具有用于安装于皮肤表面的开口部;多孔性材料，其用于吸收并浓缩从皮肤放射的皮肤气体成分 表面进入皮肤气体收集空间并且允许吸附的皮肤气体组分在相对较低的温度下解吸并且用于加热多孔材料的加热器; 以及皮肤气体测量单元，用于测量从加热的多孔材料解吸的皮肤气体成分。

    GRIMONTIA-HOLLISAE-DERIVED RECOMBINANT COLLAGENASE AND ENZYME AGENT FOR CELL SEPARATION
    2.
    发明公开
    GRIMONTIA-HOLLISAE-DERIVED RECOMBINANT COLLAGENASE AND ENZYME AGENT FOR CELL SEPARATION 审中-公开
    REKOMBINANTE COLLAGENASE AUS GRIMONTIA HOLLISAE UND ENZYMMITTEL ZUR ZELLTRENNUNG

    公开(公告)号：EP3115455A1

    公开(公告)日：2017-01-11

    申请号：EP15757886.5

    申请日：2015-03-06

    申请人： NIPPI, INCORPORATED ,  THE UNIVERSITY OF TOKYO

    发明人： TERAMURA, Naoko ,  IIJIMA, Katsumasa ,  HAYASHIDA, Osamu ,  TANAKA, Keisuke ,  HATTORI, Shunji ,  OKITSU, Teru ,  TAKEUCHI, Shoji

    IPC分类号： C12N15/09 ,  C12N9/52

    CPC分类号： C12N9/52 ,  C12Y304/24007

    摘要： Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae -derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae -derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity.

    摘要翻译： 提供具有稳定比活性的重组胶原酶和用于细胞和组织解离的酶剂，如重组体。 重组胶原酶衍生自来自海带石斛的衍生胶原酶，其特征在于从N末端至C末端具有胶原酶催化结构域，接头区序列和前肽酶C末端结构域，其中，Grimontia hollisae衍生的重组胶原酶 不至少包含前肽酶C末端结构域。 获得的重组胶原酶具有高稳定的比活性。

    THREE-DIMENSIONAL MUSCLE TISSUE AND PRODUCTION METHOD THEREFOR
    4.
    发明公开
    THREE-DIMENSIONAL MUSCLE TISSUE AND PRODUCTION METHOD THEREFOR 审中-公开

    公开(公告)号：EP3936604A1

    公开(公告)日：2022-01-12

    申请号：EP20765947.5

    申请日：2020-01-22

    申请人： NISSIN FOODS HOLDINGS CO., LTD. ,  The University of Tokyo

    发明人： TAKEUCHI, Shoji ,  MORIMOTO, Yuya ,  SHIMA, Ai ,  FURUHASHI, Mai

    IPC分类号： C12M3/00 ,  C12N5/077

    摘要： The present invention provides a production method for a three-dimensional muscle tissue including the steps of: preparing an approximately rectangular first cell module containing skeletal myoblasts in a hydrogel, and having a plurality of approximately rectangular holes parallel to each other, and an approximately rectangular second cell module containing skeletal myoblasts in a hydrogel, and having a plurality of approximately rectangular holes parallel to each other at positions different from those of the first cell module in a vertical direction; alternately stacking the prepared first cell module and the prepared second cell module to obtain a stack; subjecting the skeletal myoblasts contained in the obtained stack to proliferation culture; and inducing the proliferated skeletal myoblasts to differentiate into myotubes.

    METHOD OF PRODUCING FINELY STRUCTURED GEL
    5.
    发明公开
    METHOD OF PRODUCING FINELY STRUCTURED GEL 审中-公开
    VERFAHREN ZUR HERSTELLUNG EINES FEIN STRUKTURIERTEN GELS

    公开(公告)号：EP2666746A1

    公开(公告)日：2013-11-27

    申请号：EP12736403.2

    申请日：2012-01-06

    申请人： Terumo Kabushiki Kaisha ,  The University of Tokyo

    发明人： SHIBATA, Hideaki ,  TAKEUCHI, Shoji ,  HEO, Yun-Jung

    IPC分类号： B81C99/00 ,  C08F2/10 ,  C08F26/00

    CPC分类号： B81C1/00373 ,  B82Y30/00 ,  C08F2/10 ,  C08F220/56 ,  C08F222/385

    摘要： An object of the present invention is to provide a method of producing a fine polymer gel, which can produce the gel in large quantities in a short period of time in a very simple manner without the need for large-scale facilities.
    The present invention provides a method of producing a microstructured gel in a shape in accordance with a pattern, the method comprising the steps of: dropping a polymerizable monomer aqueous solution containing a polymerizable monomer component onto a portion of a surface of a substrate having a pattern comprising a fine groove in the surface;
    moving by capillary action the polymerizable monomer aqueous solution along the groove constituting the pattern; and
    subjecting the polymerizable monomer aqueous solution in the groove to polymerization.

    摘要翻译： 本发明的目的是提供一种能够以非常简单的方式在短时间内大量生产凝胶而不需要大规模设备的聚合物凝胶的制造方法。 本发明提供一种根据图案形成微结构凝胶的方法，该方法包括以下步骤：将含有可聚合单体组分的可聚合单体水溶液滴加到具有图案的基材表面的一部分上 包括表面上的细槽; 通过毛细作用沿着构成图案的槽移动可聚合单体水溶液; 并使槽中的可聚合单体水溶液聚合。

    METHOD FOR FABRICATING MICROARRAYS OF SOFT MATERIALS
    10.
    发明公开
    METHOD FOR FABRICATING MICROARRAYS OF SOFT MATERIALS 有权
    VERFAHREN ZUR HERSTELLUNG VON MIKROARRAYS AUS WEICHEN MATERIALIEN

    公开(公告)号：EP2594941A1

    公开(公告)日：2013-05-22

    申请号：EP12763427.7

    申请日：2012-03-27

    申请人： NTT Docomo, Inc. ,  The University of Tokyo

    发明人： HIYAMA, Satoshi ,  KURIBAYASHI, Kaori ,  ONOE, Hiroaki ,  TAKEUCHI, Shoji

    IPC分类号： G01N33/543 ,  C12M1/00 ,  C12N15/09 ,  G01N37/00

    CPC分类号： B05D1/325 ,  B01J2219/00317 ,  B01J2219/00529 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B81B2201/0214 ,  B81B2201/058 ,  B81C1/00206 ,  C12N15/09 ,  G01N33/543 ,  G01N37/00

    摘要： A method for fabricating a microarray of plural kinds of soft materials using a poly(paraxylylene) resin lift-off method, includes: a process of vapor-depositing a poly(para-xylylene) resin of a first layer on a substrate, forming a first micro pattern in the poly(para-xylylene) resin of the first layer; obtaining a substrate on which a first microarray is formed by pouring a solution of a first soft material, freeze-drying the first soft material so as to obtain a micro-arrayed substrate of the freeze-dried first soft material; a process of vapor-depositing a poly(para-xylylene) resin of a second layer on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern in a place different from the first micro pattern by penetrating the poly(para-xylylene) resin of the first layer and the second layer, forming a second microarray on the substrate by pouring a solution including a second soft material; and a process of forming a microarray of the first and the second soft materials on the same substrate by peeling off the poly(para-xylylene) resin of the first layer and the second layer.

    摘要翻译： 使用聚（对二甲苯）树脂剥离法制造多种软质材料的微阵列的方法包括：在基材上蒸镀第一层的聚（对二甲苯）树脂的方法，形成 第一层聚（对二甲苯）树脂中的第一微图案; 通过倾倒第一软质材料的溶液获得形成有第一微阵列的基板，冷冻干燥第一软质材料，得到冷冻干燥的第一软质材料的微阵列基板; 在冷冻干燥的第一软质材料的微阵列基底上气相沉积第二层的聚（对二甲苯）树脂的方法，在不同于第一微图案的位置上形成第二微图形， 聚（对二甲苯）树脂和第二层，通过倾倒包含第二软材料的溶液在基材上形成第二微阵列; 以及通过剥离第一层和第二层的聚（对二甲苯）树脂，在同一基板上形成第一和第二软质材料的微阵列的工艺。