公开(公告)号：EP3214086A1

公开(公告)日：2017-09-06

申请号：EP15855181.2

申请日：2015-10-30

申请人： Ube Industries, Ltd.

发明人： AGA, Yasuhiro ,  USHIYAMA, Shigeru ,  IWASE, Noriaki ,  KONO, Shigeyuki ,  SUNAMOTO, Hidetoshi ,  MATSUSHITA, Takashi ,  OGI, Sayaka ,  TANAKA, Masayuki ,  MATOYAMA, Masaaki ,  UMEZAKI, Satoshi ,  SHIRAISHI, Yusuke ,  ONUMA, Kazuhiro ,  KOJIMA, Masahiro ,  NISHIYAMA, Hayato ,  KIMURA, Tomio

IPC分类号： C07F7/10 ,  A61K31/695 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

CPC分类号： C07F7/10 ,  A61K31/695 ,  Y02P20/55

摘要： Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof:

wherein L 1 is an optionally substituted C 1-6 alkylene group or the like, L 2 is a single bond or the like, L 3 is a single bond or the like, R 1 , R 2 , and R 3 are each independently an optionally substituted C 1-4 alkyl group or the like, R 4 is a hydrogen atom or the like, and R 5 is a hydrogen atom or the like.

摘要翻译： 提供由式（I）表示的化合物或其药理学上可接受的盐：其中L 1是任选取代的C 1-6亚烷基等，L 2是单键等，L 3是单键等， R1，R2和R3各自独立地为任选取代的C1-4烷基等，R4为氢原子等，R5为氢原子等。

公开(公告)号：EP2940013A1

公开(公告)日：2015-11-04

申请号：EP13868493.1

申请日：2013-12-27

申请人： UBE Industries, Ltd.

发明人： IWASE, Noriaki ,  NISHIDA, Hiroshi ,  OKUDO, Makoto ,  ITO, Masaaki ,  KONO, Shigeyuki ,  MATOYAMA, Masaaki ,  USHIYAMA, Shigeru ,  OKANARI, Eiji ,  MATSUNAGA, Hirofumi ,  NISHIKAWA, Kenji ,  KIMURA, Tomio

IPC分类号： C07D333/36 ,  A61K31/381 ,  A61K31/427 ,  A61K31/443 ,  A61P13/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D409/04 ,  C07D409/14 ,  C07D417/12

CPC分类号： C07D333/36 ,  A61K31/381 ,  A61K31/427 ,  A61K31/443 ,  A61P13/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

摘要： A novel α-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided.
A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R 1 is the same or different, and represents a halogen atom, or a C 1 -C 3 alkyl group; R 2 represents a hydrogen atom, or a C 1 -C 6 alkyl group; p represents an integer of 0 to 5; V represents CR 3 wherein R 3 represents a hydrogen atom, an amino group, a nitro group, or a C 1 -C 3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.

摘要翻译： 提供了一种具有有效的LPA受体 - 拮抗剂活性并可用作药物的新型的 - - 卤素取代的噻吩化合物或其药学上可接受的盐。 由通式（I）表示的化合物，其中A表示苯基环，噻吩环或异噻唑环; R 1相同或不同，表示卤素原子或C 1〜C 3烷基; R 2表示氢原子或C 1 -C 6烷基; p表示0〜5的整数， V表示CR 3，其中R 3表示氢原子，氨基，硝基或C 1 -C 3烷氧基，或V表示氮原子; X表示卤素原子或其盐。

公开(公告)号：EP3162801B1

公开(公告)日：2020-07-22

申请号：EP15812460.2

申请日：2015-06-26

申请人： UBE Industries, Ltd.

发明人： IWASE, Noriaki ,  NISHIDA, Hiroshi ,  OKUDO, Makoto ,  ITO, Masaaki ,  KONO, Shigeyuki ,  MATOYAMA, Masaaki ,  USHIYAMA, Shigeru ,  OKANARI, Eiji ,  MATSUNAGA, Hirofumi ,  NISHIKAWA, Kenji ,  KIMURA, Tomio

IPC分类号： C07D333/36 ,  A61K31/381 ,  A61P13/00 ,  A61P19/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00

公开(公告)号：EP2940013B1

公开(公告)日：2018-02-21

申请号：EP13868493.1

申请日：2013-12-27

申请人： UBE INDUSTRIES, LTD.

发明人： IWASE, Noriaki ,  NISHIDA, Hiroshi ,  OKUDO, Makoto ,  ITO, Masaaki ,  KONO, Shigeyuki ,  MATOYAMA, Masaaki ,  USHIYAMA, Shigeru ,  OKANARI, Eiji ,  MATSUNAGA, Hirofumi ,  NISHIKAWA, Kenji ,  KIMURA, Tomio

IPC分类号： C07D333/36 ,  A61K31/381 ,  A61K31/427 ,  A61K31/443 ,  A61P13/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D409/04 ,  C07D409/14 ,  C07D417/12

CPC分类号： C07D333/36 ,  A61K31/381 ,  A61K31/427 ,  A61K31/443 ,  A61P13/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

摘要： A novel ±-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R 1 is the same or different, and represents a halogen atom, or a C 1 -C 3 alkyl group; R 2 represents a hydrogen atom, or a C 1 -C 6 alkyl group; p represents an integer of 0 to 5; V represents CR 3 wherein R 3 represents a hydrogen atom, an amino group, a nitro group, or a C 1 -C 3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.