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    MULTIVALENT ANTIBODIES
    3.
    发明公开
    MULTIVALENT ANTIBODIES 有权
    多抗体

    公开(公告)号：EP2501721A2

    公开(公告)日：2012-09-26

    申请号：EP10796094.0

    申请日：2010-11-17

    申请人： UCB Pharma, S.A.

    发明人： HUMPHREYS, David Paul ,  HEYWOOD, Sam Philip ,  LAWSON, Alastair David Griffiths

    IPC分类号： C07K16/00

    CPC分类号： C07K16/00 ,  A61K47/60 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/60 ,  C07K2317/624

    摘要： A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally V
    H 1, a C
    H 1 region and a further variable domain nominally V
    H 2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally V
    L 1, a CL domain and a variable domain nominally V
    L 2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of V
    H 1 and V
    L 1 and a second binding site formed by a second variable domain pair of V
    H 2 and V
    L 2, wherein there is a disulfide bond between a variable domain pair forming a binding site, and said fusion protein is conjugated to a PEG polymer.

    摘要翻译： 一种多价抗体融合蛋白，其包含：重链，其从N-末端依次包含可变结构域名义上V H1，C H1区域和另一可变结构域名义上V H2，轻链依次包含N 名为V L1，CL结构域和名义上为V L2的可变结构域，其中所述重链和轻链对齐以提供由V H1和V L1的第一可变结构域对形成的第一结合位点和 第二结合位点由V H2和V L2的第二可变结构域对形成，其中在形成结合位点的可变结构域对之间存在二硫键，并且所述融合蛋白与PEG聚合物缀合。

    FUNCTION MODIFYING NAV 1.7 ANTIBODIES
    4.
    发明公开
    FUNCTION MODIFYING NAV 1.7 ANTIBODIES 审中-公开
    FUNKTIONELLE MODIFIZIERUNG VON NAV1.7-ANTIKÖRPERN

    公开(公告)号：EP2493926A1

    公开(公告)日：2012-09-05

    申请号：EP10770839.8

    申请日：2010-10-27

    申请人： UCB Pharma, S.A.

    发明人： MILLER, Karen Margrete ,  DE RYCK, Marc Roger ,  WOLFF, Christian Gilbert J. ,  LAWSON, Alastair David Griffiths ,  FINNEY, Helene Margaret ,  BAKER, Terence Seward

    IPC分类号： C07K16/28

    摘要： A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

    摘要翻译： 结合后的Nav1.7结合实体功能性地修饰离子通道的活性，特别是抗Nav1.7抗体或其结合片段，包含所述抗体的药物组合物，抗体及其组合物在治疗中的用途 ，例如在疼痛的治疗/调节中以及产生和制备所述抗体的方法。