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公开(公告)号：EP1575419A4
公开(公告)日：2009-11-11
申请号：EP03786898
申请日：2003-12-10
申请人： UNIV DUKE , UNIV MONTANA STATE
发明人： STAMLER JONATHAN S , SINGEL DAVID J
IPC分类号： A01N1/02 , A61B20060101 , A61B1/00 , A61K35/14 , A61K38/16 , A61M1/02 , A61M1/36 , C07K14/805
CPC分类号： C07K14/805
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公开(公告)号：EP2170157A4
公开(公告)日：2013-03-27
申请号：EP08794495
申请日：2008-07-15
申请人： UNIV DUKE
发明人： STAMLER JONATHAN S , ANGELO MICHAEL
IPC分类号： A61B5/00
CPC分类号： G01N33/84 , A61B5/0059 , A61B5/1405 , A61B5/14546 , A61B5/150022 , A61B5/150251 , A61B5/150343 , A61B5/412 , G01N27/416 , Y10T436/177692
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3.发明公开
公开(公告)号：EP1633311A4
公开(公告)日：2009-06-03
申请号：EP04776296
申请日：2004-06-04
申请人： UNIV DUKE
发明人： STAMLER JONATHAN S , LIMIN LIN
IPC分类号： A01K67/027 , A61K20060101 , A61K31/198 , A61K38/18 , A61K38/44 , C12N5/10 , C12N15/85 , G01N33/573
CPC分类号： G01N33/573 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K31/155 , A61K31/41 , A61K38/44 , C12N9/0008 , C12N15/8509 , C12Q1/26 , C12Y102/01046 , G01N2333/90212 , G01N2800/00 , A61K2300/00
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公开(公告)号：EP1349562A4
公开(公告)日：2008-08-06
申请号：EP01987141
申请日：2001-12-14
申请人： UNIV DUKE
IPC分类号： A61K38/06 , A61K31/365 , A61K31/7056 , A61P1/16 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P15/10 , A61P19/02 , A61P29/00 , A61P31/04 , A61P31/10 , A61P33/10 , A61P35/00
CPC分类号： A61K38/063 , A61K31/365 , A61K31/7056 , Y10S514/824
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5.发明公开REACTIVE OXYGEN GENERATING ENZYME INHIBITOR WITH NITRIC OXIDE BIOACTIVITY AND USES THEREOF 审中-公开活性氧生成酶与有机硝酸效应及其应用抑制剂
公开(公告)号：EP1737867A4
公开(公告)日：2008-03-05
申请号：EP05736907
申请日：2005-04-20
申请人： UNIV DUKE , UNIV JOHNS HOPKINS
发明人： STAMLER JONATHAN S , TOONE ERIC J , HARE JOSHUA M
IPC分类号： C07D487/04 , A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519
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公开(公告)号：EP1514103A4
公开(公告)日：2006-05-24
申请号：EP03756165
申请日：2003-05-27
申请人： UNIV DUKE
CPC分类号： G01N33/84 , G01N33/4925
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7.发明公开
公开(公告)号：EP1229954A4
公开(公告)日：2005-05-25
申请号：EP00955290
申请日：2000-08-18
申请人： UNIV DUKE
发明人： STAMLER JONATHAN S , TOONE ERIC J , GOW ANDREW J
IPC分类号： G01N31/00 , A61K9/72 , A61K31/16 , A61K31/166 , A61K31/197 , A61K31/21 , A61K33/00 , A61K33/04 , A61K35/14 , A61K35/18 , A61K45/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P21/00 , A61P29/00 , G01N33/15 , G01N33/50 , A61M15/00 , A01K31/16 , A61M16/00 , A62B7/00 , A62B9/00 , A62B18/00
CPC分类号： C12N5/0641 , A61K31/197 , A61K31/21 , A61K33/00 , A61K33/04 , A61M2202/0275 , A61K2300/00
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公开(公告)号：EP2056819A4
公开(公告)日：2011-09-07
申请号：EP07810717
申请日：2007-07-24
申请人： UNIV DUKE
发明人： STAMLER JONATHAN S
IPC分类号： A61K31/04 , A61K31/095 , A61K31/19 , A61K31/21 , A61K31/34 , A61K31/4406 , A61K45/06 , A61P3/06
CPC分类号： A61K31/19 , A61K31/04 , A61K31/095 , A61K31/21 , A61K31/34 , A61K31/4406 , A61K45/06 , A61K2300/00
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公开(公告)号：EP1567182A4
公开(公告)日：2010-09-08
申请号：EP03777526
申请日：2003-10-20
申请人： UNIV DUKE
IPC分类号： A61K45/00 , A61K20060101 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/21 , A61K31/223 , A61K31/5377 , A61K38/00 , A61K38/05 , A61K38/06 , A61P1/00 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/22 , A61P25/24
CPC分类号： A61K31/21 , A61K31/19 , A61K31/223 , A61K31/5377 , A61K38/063
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10.发明公开
公开(公告)号：EP0963219A4
公开(公告)日：2002-11-13
申请号：EP97938149
申请日：1997-08-13
IPC分类号： A61K31/00 , A61K31/195 , A61K31/255 , C07C381/10 , A61N1/362 , A61K39/395 , A61K39/40 , A61P9/00 , A61P31/00 , A61P33/00 , A61P35/00 , G01N31/00 , G01N33/00 , G01N33/03 , G01N33/26 , G01N33/554 , G01N33/569 , G01N33/574
CPC分类号： A61K31/00 , A61K31/195 , A61K31/255 , C07C381/10
摘要： Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infection or of host cells infected with the microbes or of the pathologically proliferating mammalian cells. Novel agents include alpha-alkyl-S-alkyl-homocysteine sulfoxmines wherein the alpha-alkyl contains 2 to 8 carbon atoms, and the S-alkyl contains 1 to 10 carbon atoms. Mammals in need of increased nitrosative stress defenses are treated, e.g., humans at risk for a stroke because of having had a transient ischemic attack, are treated. Treatments to increase nitrosative stress defenses include repeated administrations of low doses of manipulators of nitrosative stress so that the subject treated has increased tolerance to nitrosative stress. Mammals are treated for protozoal infections by systemic administration of L-buthionine-S-sulfoximine and agent that increases nitrosative stress.
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