公开(公告)号：EP0560885A4

公开(公告)日：1994-06-08

申请号：EP92901454

申请日：1991-12-04

申请人： UNIV FLORIDA

发明人： INGRAM LONNIE O ,  OHTA KAZUYOSHI

IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N9/04 ,  C12N9/88 ,  C12N15/01 ,  C12N15/31 ,  C12N15/53 ,  C12N15/60 ,  C12N15/70 ,  C12N15/74 ,  C12N15/90 ,  C12P7/06 ,  C12R1/18 ,  C12R1/19 ,  C12R1/22

CPC分类号： C12N9/0006 ,  C12N9/88 ,  C12N15/01 ,  C12N15/70 ,  C12N15/74 ,  C12N15/902 ,  C12P7/065 ,  Y02E50/17

摘要： Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

公开(公告)号：EP1527164A4

公开(公告)日：2006-02-01

申请号：EP02789143

申请日：2002-04-29

申请人： UNIV FLORIDA

发明人： MAUPIN-FURLOW JULIE A ,  TALARICO LEE ANN ,  RAJ KRISHNAN CHANDRA ,  INGRAM LONNIE O

IPC分类号： G01N33/53 ,  C07H21/04 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N9/88 ,  C12N15/09 ,  C12N15/74 ,  C12P7/06 ,  C12P7/24 ,  C12P21/02 ,  C12Q1/527 ,  C12Q1/68 ,  G01N33/566 ,  C12N9/00

CPC分类号： C12N9/88 ,  Y02E50/17

公开(公告)号：EP2041293A4

公开(公告)日：2011-06-22

申请号：EP07835737

申请日：2007-04-26

申请人： UNIV FLORIDA

发明人： KIM YOUNGNYUN ,  SHANMUGAM KEELNATHAM ,  INGRAM LONNIE O

IPC分类号： C12P7/06 ,  C12N1/20 ,  C12P7/08

CPC分类号： C12N15/01 ,  C12N9/0051 ,  C12P7/06 ,  Y02E50/17

公开(公告)号：EP2054503A4

公开(公告)日：2010-12-01

申请号：EP07811186

申请日：2007-08-08

申请人： UNIV FLORIDA

发明人： YOMANO LORRAINE P ,  YORK SEAN W ,  ZHOU SHENGDE ,  SHANMUGAM KEELNATHAM ,  INGRAM LONNIE O

IPC分类号： C12N1/21 ,  C12P7/06

CPC分类号： C12P7/065 ,  Y02E50/17

公开(公告)号：EP0576621A4

公开(公告)日：1994-11-02

申请号：EP92910933

申请日：1992-03-18

申请人： UNIV FLORIDA ,  BIOENERGY INT L C

发明人： INGRAM LONNIE O ,  BEALL DAVID S ,  BURCHHARDT GERHARD F H ,  GUIMARAES WALTER V ,  OHTA KAZUYOSHI ,  WOOD BRENT E ,  SHANMUGAM KEELNATHAM T ,  FOWLER DAVID A ,  BEN-BASSAT ARIE

IPC分类号： C12M1/00 ,  C12M1/02 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/04 ,  C12N9/24 ,  C12N9/88 ,  C12N15/09 ,  C12N15/52 ,  C12P7/06 ,  C12R1/18 ,  G06T1/00 ,  C12N5/00 ,  C07H15/12 ,  C12N15/00 ,  C12N15/63 ,  C12N15/74 ,  C12N15/80 ,  C12P7/08

CPC分类号： C12N9/0006 ,  C12N9/248 ,  C12N9/88 ,  C12N15/52 ,  C12P7/065 ,  C12Y101/01001 ,  E05Y2900/132 ,  G06T1/00 ,  Y02E50/17 ,  Y10S435/847 ,  Y10S435/854