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公开(公告)号：EP2822546A4
公开(公告)日：2015-10-28
申请号：EP13758061
申请日：2013-03-06
发明人： HERGENROTHER PAUL J , BOTHAM RACHEL C , FAN TIMOTHY M , GILBERT MARK J , HANDLEY MICHAEL K , JOSHI AVADHUT , RIGGINS GREGORY J , TARASOW THEODORE M
IPC分类号： A61K31/495 , A61K9/00 , A61K9/20 , A61K9/48 , A61K31/4188 , A61K47/10 , A61P35/00
CPC分类号： A61K31/495 , A61K9/0019 , A61K9/008 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/4188 , A61K47/10 , A61K2300/00
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公开(公告)号：EP2984184A4
公开(公告)日：2016-11-30
申请号：EP14783210
申请日：2014-04-08
申请人： UNIV ILLINOIS , UNIV TEXAS
发明人： HERGENROTHER PAUL J , BOOTHMAN DAVID A , BAIR JOSEPH S , CAO LIFEN , GAO JIMMING , HUANG XIUMEI , LUO XIUQUAN , MA XINPENG , MOORE ZACHARY R , PARKINSON ELIZABETH I
IPC分类号： A61K31/353 , A61K31/131 , A61K31/352 , A61K31/4738 , A61K31/4745 , A61K31/706 , A61K45/06 , A61P35/00 , C12Q1/68
CPC分类号： A61K31/706 , A61K31/131 , A61K31/353 , A61K31/4738 , A61K31/4745 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , A61K2300/00
摘要： The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.
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3.发明公开PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS 审中-公开磷含氮化合物黑色素瘤TRIPHENYLMETHYLPHOSPHONATESTERN或其他肿瘤的治疗
公开(公告)号：EP2034828A4
公开(公告)日：2011-04-06
申请号：EP07797600
申请日：2007-05-18
申请人： UNIV ILLINOIS
CPC分类号： C07F9/4056 , C07F9/4075 , C07F9/425 , C07F9/582 , C07F9/65122 , C07F9/65182 , C07F9/65522 , C07F9/6561 , C07F9/657181
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公开(公告)号：EP2880020A4
公开(公告)日：2016-01-20
申请号：EP13825092
申请日：2013-08-05
申请人： UNIV ILLINOIS
IPC分类号： C07D295/12 , A61K31/495 , A61K31/496 , A61P35/00 , C07D295/125 , C07D403/12
CPC分类号： C07D295/16 , C07D295/15 , G01N33/5011 , G01N2500/02 , G01N2500/10
摘要： The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.
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公开(公告)号：EP2819661A4
公开(公告)日：2015-08-19
申请号：EP13755595
申请日：2013-03-04
发明人： HERGENROTHER PAUL J , BOTHAM RACHEL C , FAN TIMOTHY M , GILBERT MARK J , HANDLEY MICHAEL K , TARASOW THEODORE M
IPC分类号： A61K31/05 , A61K31/085 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/37 , A61K31/4184 , A61K31/4965 , A61K47/40 , A61P35/00 , A61P35/02
CPC分类号： A61K31/495 , A61K9/0019 , A61K9/008 , A61K9/2054 , A61K9/4858 , A61K31/437 , A61K47/40 , A61K2300/00
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6.发明公开SELECTIVE APOPTOTIC INDUCTION IN CANCER CELLS INCLUDING ACTIVATION OF PROCASPASE-3 有权选择性诱导细胞凋亡的肿瘤细胞具有激活胱天蛋白酶-3
公开(公告)号：EP1893210A4
公开(公告)日：2010-09-01
申请号：EP06771588
申请日：2006-05-26
申请人： UNIV ILLINOIS
IPC分类号： A61K31/495 , A61P35/00 , C07D295/15
CPC分类号： A61K31/495 , C07D295/15 , C12Q1/37 , G01N33/502 , G01N33/574 , G01N2333/96466 , G01N2510/00 , G01N2800/52
摘要： Compounds and related methods for synthesis, and the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3, and particular embodiments are capable of direct activation of procaspase-3 and procaspase-7 to the effector forms of caspase-3 and caspase-7. Procaspase-3 levels can vary among cancer cell types; several types have relatively high levels and can have increased susceptibility to chemotherapy by compounds and methods herein. Therapeutic applications are relevant for a variety of cancer conditions and cell types, e.g. breast, lung, brain, colon, renal, adrenal, melanoma, and others.
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