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公开(公告)号：EP2872493A4
公开(公告)日：2016-04-13
申请号：EP13817021
申请日：2013-07-12
IPC分类号： C07D261/06 , A61K31/42 , A61P21/00 , C07D413/12
CPC分类号： C07D493/04 , C07C311/37 , C07C2601/08 , C07C2603/20 , C07D213/75 , C07D215/227 , C07D215/44 , C07D221/10 , C07D231/14 , C07D233/88 , C07D239/47 , C07D239/82 , C07D261/06 , C07D261/14 , C07D261/18 , C07D263/48 , C07D267/14 , C07D277/46 , C07D285/135 , C07D401/04 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07K14/47
摘要： Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
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公开(公告)号：EP2192838A4
公开(公告)日：2011-07-27
申请号：EP08795375
申请日：2008-08-15
发明人： CUNY GREGORY D , TENG XIN , YUAN JUNYING , DEGTEREV ALEXEI , PORCO JOHN A JR
CPC分类号： C07D417/12 , C07D207/34 , C07D231/14 , C07D241/24 , C07D263/34 , C07D277/56 , C07D285/06 , C07D307/68 , C07D307/84 , C07D333/38
摘要： The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-±) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-± induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.
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公开(公告)号：EP2964651A4
公开(公告)日：2016-11-30
申请号：EP14760191
申请日：2014-03-04
IPC分类号： C07D487/04 , A61K31/519 , A61P3/00 , A61P3/04 , A61P3/06 , A61P9/00
CPC分类号： C07D487/04
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公开(公告)号：EP2970311A4
公开(公告)日：2016-11-23
申请号：EP14775808
申请日：2014-03-13
发明人： ALIMARDANOV ASAF , CUNY GREGORY D , GREWAL GURMIT SINGH , LEE ARTHUR , MCKEW JOHN C , MOHEDAS AGUSTIN H , SHEN MIN , XU XIN , YU PAUL B
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61P5/30 , A61P9/10 , A61P27/00 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.
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5.发明公开
公开(公告)号：EP2451779A4
公开(公告)日：2013-04-24
申请号：EP10797846
申请日：2010-07-08
发明人： RAINES DOUGLAS E , FORMAN STUART A , MILLER KEITH W , HUSAIN SYED S , CUNY GREGORY D , COTTON JOSEPH F
IPC分类号： C07D207/34 , A61K31/40 , A61P5/38 , A61P25/00
CPC分类号： C07D207/34 , A61K31/40
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公开(公告)号：EP2467362A4
公开(公告)日：2013-06-26
申请号：EP10810484
申请日：2010-08-17
发明人： STEIN ROSS L , COHEN DAVID , WAGLE NEIL , CUNY GREGORY D , XIAN JUN , GLICKSMAN MARCIE , SHISHOVA EKATERINA Y
IPC分类号： C07D239/32 , A61K31/4402 , A61K31/505 , A61P3/04 , C07D213/60
CPC分类号： C07D239/69 , A61K31/44 , A61K31/505 , C07C311/21 , C07D213/60 , C07D213/76 , C07D213/89 , C07D217/22 , C07D239/32 , C07D239/42
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公开(公告)号：EP2265603A4
公开(公告)日：2011-08-24
申请号：EP09720039
申请日：2009-03-13
IPC分类号： C07D403/04 , C07D403/02 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
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公开(公告)号：EP1968583A4
公开(公告)日：2010-09-15
申请号：EP06847822
申请日：2006-12-20
IPC分类号： C07D225/04 , A61K31/4178 , A61K31/513 , A61P25/28
CPC分类号： C07D231/54 , A61K31/4178 , C07D403/06 , C07D491/052 , C07D495/04
摘要： The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described.
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